Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
29412506
TITLE
No evidence of association of oxytocin polymorphisms with breastfeeding in 2 independent samples.
ABSTRACT
Oxytocin has an important function in breastfeeding via its role in the milk ejection reflex and in attachment and bonding processes. Genetic factors account for a significant part of the individual differences in breastfeeding behavior. OXT and OXTR have been proposed as gene candidates for breastfeeding. Previous studies have focused on certain single-nucleotide polymorphisms (SNPs) within these genes, finding null or inconsistent results. The present study analyses the associations between a wide coverage of polymorphisms in OXT and OXTR and breastfeeding duration from 2 large and independent unselected samples comprising a total of 580 and 2112 female twin mothers from the Murcia Twin Registry (Spain) and QIMR Berghofer Medical Research Institute (Australia), respectively. A total of 19 SNPs in OXT and 137 in OXTR SNPs were covered in both samples. Effects of the OXT and OXTR polymorphisms on breastfeeding duration were calculated by means of linear regression controlling for age at survey time, educational level, interaction between age and educational level and principal components of genetic ancestry. The analyses were conducted independently in the 2 samples and also meta-analyzed. Although some SNPs were associated at an alpha level of .05 with breastfeeding, they did not survive multiple testing correction. We conclude that SNPs within or nearby OXT and OXTR are unlikely to have large effects on breastfeeding behavior.
2018 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.
DATE PUBLISHED
2018 Feb 07
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2017/01/12
revised 2018/01/17
accepted 2018/02/01
pubmed 2018/02/08 06:00
medline 2018/02/08 06:00
entrez 2018/02/08 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Colodro-Conde L Colodro-Conde L L Human Anatomy and Psychobiology Department, University of Murcia, Murcia, Spain.
Sánchez-Romera JF Sánchez-Romera J F JF Human Anatomy and Psychobiology Department, University of Murcia, Murcia, Spain.
Lind PA Lind P A PA Genetics & Computational Biology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Zhu G Zhu G G Genetics & Computational Biology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Martin NG Martin N G NG Genetics & Computational Biology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Medland SE Medland S E SE Genetics & Computational Biology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Ordoñana JR Ordoñana J R JR Human Anatomy and Psychobiology Department, University of Murcia, Murcia, Spain.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Genes, brain, and behavior
ISOABBREVIATION: Genes Brain Behav.
YEAR: 2018
MONTH: Feb
DAY: 07
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1601-183X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Genes Brain Behav
COUNTRY: England
ISSNLINKING: 1601-183X
NLMUNIQUEID: 101129617
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
P50 AA011998 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
OXT
OXTR
association
breastfeeding
genetics
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's