Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
29201279
TITLE
MAPPING AGE EFFECTS ALONG FIBER TRACTS IN YOUNG ADULTS.
ABSTRACT
Brain development is a protracted and dynamic process. Many studies have charted the trajectory of white matter development, but here we sought to map these effects in greater detail, based on a large set of fiber tracts automatically extracted from HARDI (high angular resolution diffusion imaging) at 4 tesla. We used autoMATE (automated multi-atlas tract extraction) to extract diffusivity measures along 18 of the brain's major fiber bundles in 667 young adults, aged 18-30. We examined linear and non-linear age effects on diffusivity measures, pointwise along tracts. All diffusivity measures showed both linear and non-linear age effects. Tracts with the most pronounced age effects were those that connected the temporal lobe to the rest of the brain. Nonlinear age effects were picked up strongly in the anterior corpus callosum and right temporo-parietal tracts.
DATE PUBLISHED
2017
HISTORY
PUBSTATUS PUBSTATUSDATE
pmc-release 2018/06/19
entrez 2017/12/05 06:00
pubmed 2017/12/05 06:00
medline 2017/12/05 06:01
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Dennis EL Dennis Emily L EL Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.
Rashid F Rashid Faisal F Imaging Genetics Center, USC Keck School of Medicine, Marina del Rey, CA, USA.
Faskowitz J Faskowitz Josh J Imaging Genetics Center, USC Keck School of Medicine, Marina del Rey, CA, USA.
Jin Y Jin Yan Y Imaging Genetics Center, USC Keck School of Medicine, Marina del Rey, CA, USA.
McMahon KL McMahon Katie L KL Center for Advanced Imaging, Univ. of Queensland, Brisbane, Australia.
de Zubicaray GI de Zubicaray Greig I GI School of Psychology, University of Queensland, Brisbane, Australia.
Martin NG Martin Nicholas G NG Queensland Institute of Medical Research, Brisbane, Australia.
Hickie IB Hickie Ian B IB Brain and Mind Centre, University of Sydney, Australia.
Wright MJ Wright Margaret J MJ Queensland Brain Institute, University of Queensland, Brisbane, Australia.
Jahanshad N Jahanshad Neda N Imaging Genetics Center, USC Keck School of Medicine, Marina del Rey, CA, USA.
Thompson PM Thompson Paul M PM Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology, USC, Los Angeles, CA.
INVESTIGATORS
JOURNAL
VOLUME: 2017
ISSUE:
TITLE: Proceedings. IEEE International Symposium on Biomedical Imaging
ISOABBREVIATION: Proc IEEE Int Symp Biomed Imaging
YEAR: 2017
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1945-7928
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Proc IEEE Int Symp Biomed Imaging
COUNTRY: United States
ISSNLINKING: 1945-7928
NLMUNIQUEID: 101492570
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 EB007813 NIBIB NIH HHS United States
R01 AG040060 NIA NIH HHS United States
K99 NS096116 NINDS NIH HHS United States
U54 EB020403 NIBIB NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
R01 EB008432 NIBIB NIH HHS United States
P41 RR013642 NCRR NIH HHS United States
R01 NS080655 NINDS NIH HHS United States
R01 EB008281 NIBIB NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
development
diffusion weighted imaging
structural connectivity
tractography
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's