Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
29186515
TITLE
Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study.
ABSTRACT
Background NlmCategory: UNASSIGNED
Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal.
Methods NlmCategory: UNASSIGNED
We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using a Wald-type ratio estimator.
Results NlmCategory: UNASSIGNED
For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80 mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases.
Conclusions NlmCategory: UNASSIGNED
We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations.
DATE PUBLISHED
2017 Nov 25
HISTORY
PUBSTATUS PUBSTATUSDATE
accepted 2017/10/21
entrez 2017/11/30 06:00
pubmed 2017/12/01 06:00
medline 2017/12/01 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Ong JS Ong Jue-Sheng JS School of Medicine, University of Queensland, St Lucia, QLD, Australia.
Hwang LD Hwang Liang-Dar LD School of Medicine, University of Queensland, St Lucia, QLD, Australia.
Cuellar-Partida G Cuellar-Partida Gabriel G Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Martin NG Martin Nicholas G NG Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Chenevix-Trench G Chenevix-Trench Georgia G Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Quinn MCJ Quinn Michael C J MCJ Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Cornelis MC Cornelis Marilyn C MC Northwestern University Feinberg School of Medicine, Preventive Medicine, Chicago, IL, USA.
Gharahkhani P Gharahkhani Puya P Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Webb PM Webb Penelope M PM Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
MacGregor S MacGregor Stuart S Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Ovarian Cancer Association Consortium
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Bowtell D D
deFazio A A
Gertig D D
Green A A
Parsons P P
Hayward N N
Whiteman D D
Peuteman G G
Van Brussel T T
Smeets D D
Gacucova L L
Schurmann P P
Kramer F F
Zheng W W
Park T W TW
Simon
Beer-Grondke K K
Schmidt D D
Windebank S S
Hilker C C
Vollenweider J J
Paddock L L
King M M
Rodriguez-Rodriguez L L
Samoila A A
Bensman Y Y
Sherman M M
Hutchinson A A
Szeszenia-Dabrowska N N
Peplonska B B
Zatonski W W
Soni A A
Chao P P
Stagner M M
Luccarini C C
Harrington P P
Jacobs I I
Widschwendter M M
Wozniak E E
Balogun N N
Ryan A A
Karpinskyj C C
Ford J J
Pye Carole C
Amin Al Olama A A
Dennis J J
Dicks E E
Michilaidou K K
Kuchenbaker K K
Ong Jue-Sheng JS
Hwang Liang-Dar LD
Cuellar-Partida Gabriel G
Bryne Enda E
Fasching Peter A PA
Hein Alexander A
Burghaus Stefanie S
Beckmann Matthias W MW
Lambrechts Diether D
Van Nieuwenhuysen Els E
Vergote Ignace I
Vanderstichele Adriaan A
Swerdlow Anthony J AJ
Jones Michael M
Orr Nicholas N
Schoemaker Minouk M
Edwards Digna Velez DV
Brenton James J
Benítez Javier J
García María J MJ
Rodriguez-Antona Cristina C
Rossing Mary Anne MA
Fortner Renée T RT
Riboli Elio E
Chang-Claude Jenny J
Eilber Ursula U
Wang-Gohrke Shan S
Yannoukakos Drakoulis D
Goodman Marc T MT
Bogdanova Natalia N
Dörk Thilo T
Duerst Matthias M
Hillemanns Peter P
Runnebaum Ingo B IB
Antonenkova Natalia N
Butzow Ralf R
Nevanlinna Heli H
Pelttari Liisa M LM
Edwards Robert P RP
Kelley Joseph L JL
Modugno Francesmary F
Moysich Kirsten B KB
Ness Roberta B RB
Cannioto Rikki R
Heitz Florian F
Karlan Beth B
Olsson Håkan H
Kjaer Susanne K SK
Jensen Allan A
Giles Graham G GG
Bruinsma Fiona F
Hildebrandt Michelle A T MAT
Liang Dong D
Wu Xifeng X
Le Marchand Loic L
Setiawan V Wendy VW
Permuth Jennifer B JB
Bisogna Maria M
Dao Fanny F
Levine Douglas A DA
Cramer Daniel W DW
Terry Kathryn L KL
Tworoger Shelley S SS
Stampfer Meir M
Willet Walter W
Missmer Stacey S
Bjorge Line L
Kopperud Reidun K RK
Bischof Katharina K
Vestrheim Thomsen Liv Cecilie LC
Kiemeney Lambertus A LA
Massuger Leon Fag LF
Pejovic Tanja T
Brooks-Wilson Angela A
Olson Sara H SH
McGuire Valerie V
Rothstein Joseph H JH
Sieh Weiva W
Whittemore Alice S AS
Cook Linda S LS
Le Nhu D ND
Gilks C Blake CB
Gronwald Jacek J
Jakubowska Anna A
Lubiński Jan J
Kluz Tomasz T
Wentzensen Nicolas N
Brinton Louise L
Trabert Britton B
Lissowska Jolanta J
Høgdall Estrid E
Høgdall Claus K CK
Sandler Dale P DP
Wolk Alicja A
Tyrer Jonathan P JP
Song Honglin H
Eccles Diana D
Campbell Ian I
Glasspool Ros R
McNeish Iain I
Paul James J
Siddiqui Nadeem N
Sutphen Rebecca R
McLaughlin John R JR
Phelan Catherine C
Anton-Culver Hoda H
Ziogas Argyrios A
May Taymaa T
Gayther Simon A SA
Gentry-Maharaj Aleksandra A
Menon Usha U
Ramus Susan J SJ
Wu Anna H AH
Huntsman David D
deFazio Anna A
Dansonka-Mieszkowska Agnieszka A
Kupryjanczyk Jolanta J
Moes-Sosnowska Joanna J
Szafron Lukasz Michal LM
Cunningham Julie M JM
Winham Stacey J SJ
Risch Harvey A HA
Goode Ellen L EL
Schildkraut Joellen M JM
Pearce Celeste L CL
Berchuck Andrew A
Pharoah Paul D P PDP
Martin Nicholas G NG
Chenevix-Trench Georgia G
Quinn Michael C J MCJ
Cornelis Marilyn C MC
Gharahkhani Puya P
Webb Penelope M PM
MacGregor Stuart S
JOURNAL
VOLUME:
ISSUE:
TITLE: International journal of epidemiology
ISOABBREVIATION: Int J Epidemiol
YEAR: 2017
MONTH: Nov
DAY: 25
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1464-3685
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Int J Epidemiol
COUNTRY: England
ISSNLINKING: 0300-5771
NLMUNIQUEID: 7802871
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Mendelian randomization
caffeine
causality
coffee
ovarian cancer
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's