Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
2880556
TITLE
Genetics of human cancer.
ABSTRACT
Study of hereditary cancer in humans has revealed new mechanisms in carcinogenesis. In particular, a new class of cancer gene, recessive in oncogenesis, accounts for dominantly transmitted predisposition to some cancers, and may play a primary role in the nonhereditary forms of most cancers. Comparison of polymorphic markers in lymphocytes and tumors has permitted the in vivo observation of somatic events that lead to genetic recombination. The tissue specificities of these recessive cancer genes suggest that their normal alleles, like those of oncogenes, play important roles in normal development.
DATE PUBLISHED
1986
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1986/01/01
medline 2001/03/28 10:01
entrez 1986/01/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Knudson AG Jr Knudson A G AG
INVESTIGATORS
JOURNAL
VOLUME: 20
ISSUE:
TITLE: Annual review of genetics
ISOABBREVIATION: Annu. Rev. Genet.
YEAR: 1986
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0066-4197
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Annu Rev Genet
COUNTRY: United States
ISSNLINKING: 0066-4197
NLMUNIQUEID: 0117605
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
CA-06927 NCI NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Chromosome Aberrations
Chromosome Deletion
Chromosome Fragility
Chromosomes, Human ultrastructure
DNA Repair ultrastructure
Genes, Dominant ultrastructure
Genes, Recessive ultrastructure
Genetic Markers ultrastructure
Humans ultrastructure
Kidney Neoplasms genetics
Mutation genetics
Neoplasms genetics
Oncogenes genetics
Polymorphism, Restriction Fragment Length genetics
Proto-Oncogenes genetics
Retinoblastoma genetics
Sequence Homology, Nucleic Acid genetics
Wilms Tumor genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Genetic Markers
OTHER ID's