Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
28715705
TITLE
Investigating the relationship between iron and depression.
ABSTRACT
Lower levels of circulating iron have been associated with depression. Our objective was to investigate the phenotypic and genetic relationship between measures of circulating levels of iron (serum iron, transferrin, transferrin saturation, and ferritin) and depressive symptoms. Data were available from ongoing studies at QIMR Berghofer Medical Research Institute (QIMRB), including twin adolescents (mean age 15.1 years, standard deviation (SD) 3.2 years), and twin adults (mean age 23.2 years, SD 2.2 years). In the adolescent cohort, there were 3416 participants from 1688 families. In the adult cohort there were 9035 participants from 4533 families. We estimated heritabilities of, and phenotypic and genetic correlations between, traits. We conducted analyses that linked results from published large-scale genome-wide association studies (including iron and Major Depressive Disorder) with our study samples using single SNP and multi-SNP genetic risk score analyses, and LD score regression analyses. In both cohorts, measures of iron, transferrin, transferrin saturation, and log 10 of ferritin (L10Fer) were all highly heritable, while depressive measures were moderately heritable. In adolescents, depression measures were higher in those in the middle 10th versus top 10th percentile of transferrin saturation measures (p = 0.002). Genetic profile risk scores of the iron measures were not significantly associated with depression in study participants. LD score analyses showed no significant genetic relationship between iron and depression. Genetic factors strongly influence iron measures in adolescents and adults. Using several different strategies we find no evidence for a genetic contribution to the relationship between blood measures of iron and measures of depression.
Copyright 2017 Elsevier Ltd. All rights reserved.
DATE PUBLISHED
2017 Jul 08
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2017/02/25
revised 2017/06/03
accepted 2017/07/07
entrez 2017/07/18 06:00
pubmed 2017/07/18 06:00
medline 2017/07/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Mills NT Mills Natalie T NT Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia; Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, 5000, Australia; Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia. Electronic address: natalie.mills@adelaide.edu.au.
Maier R Maier Robert R Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia.
Whitfield JB Whitfield John B JB Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia.
Wright MJ Wright Margaret J MJ Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia.
Colodro-Conde L Colodro-Conde Lucia L Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia.
Byrne EM Byrne Enda M EM Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia.
Scott JG Scott James G JG The University of Queensland, UQ Centre for Clinical Research, Herston, 4029, Australia; Metro North Mental Health, Royal Brisbane and Women's Hospital, Brisbane, 4006, Australia; Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Brisbane, 4076, Australia.
Byrne GJ Byrne Gerard J GJ Academic Discipline of Psychiatry, School of Medicine, The University of Queensland, Brisbane, Australia.
Hansell NK Hansell Narelle K NK Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia.
Vinkhuyzen AAE Vinkhuyzen Anna A E AAE Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia.
CouvyDuchesne B CouvyDuchesne Baptiste B Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia; Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia.
Montgomery GW Montgomery Grant W GW Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia.
Henders AK Henders Anjali K AK Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia.
Martin NG Martin Nicholas G NG Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia.
Wray NR Wray Naomi R NR Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia.
Benyamin B Benyamin Beben B Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 94
ISSUE:
TITLE: Journal of psychiatric research
ISOABBREVIATION: J Psychiatr Res
YEAR: 2017
MONTH: Jul
DAY: 08
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1879-1379
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Psychiatr Res
COUNTRY: England
ISSNLINKING: 0022-3956
NLMUNIQUEID: 0376331
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Depression
Ferritin
Iron
Transferrin
Transferrin saturation
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's