Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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28696435
TITLE
A direct test of the diathesis-stress model for depression.
ABSTRACT
The diathesis-stress theory for depression states that the effects of stress on the depression risk are dependent on the diathesis or vulnerability, implying multiplicative interactive effects on the liability scale. We used polygenic risk scores for major depressive disorder (MDD) calculated from the results of the most recent analysis from the Psychiatric Genomics Consortium as a direct measure of the vulnerability for depression in a sample of 5221 individuals from 3083 families. In the same we also had measures of stressful life events and social support and a depression symptom score, as well as DSM-IV MDD diagnoses for most individuals. In order to estimate the variance in depression explained by the genetic vulnerability, the stressors and their interactions, we fitted linear mixed models controlling for relatedness for the whole sample as well as stratified by sex. We show a significant interaction of the polygenic risk scores with personal life events (0.12% of variance explained, P-value=0.0076) contributing positively to the risk of depression. Additionally, our results suggest possible differences in the aetiology of depression between women and men. In conclusion, our findings point to an extra risk for individuals with combined vulnerability and high number of reported personal life events beyond what would be expected from the additive contributions of these factors to the liability for depression, supporting the multiplicative diathesis-stress model for this disease.Molecular Psychiatry advance online publication, 11 July 2017; doi:10.1038/mp.2017.130.
DATE PUBLISHED
2017 Jul 11
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/12/19
revised 2017/04/07
accepted 2017/04/28
entrez 2017/07/12 06:00
pubmed 2017/07/12 06:00
medline 2017/07/12 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Colodro-Conde L Colodro-Conde L L Department of Human Anatomy and Psychobiology, University of Murcia, Murcia, Spain.
Couvy-Duchesne B Couvy-Duchesne B B Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Zhu G Zhu G G Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Coventry WL Coventry W L WL School of Behavioural and Social Sciences, University of New England, Armidale, NSW, Australia.
Byrne EM Byrne E M EM Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Gordon S Gordon S S Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Wright MJ Wright M J MJ Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia.
Montgomery GW Montgomery G W GW Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Madden PAF Madden P A F PAF Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Ripke S Ripke S S Department of Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Eaves LJ Eaves L J LJ Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Heath AC Heath A C AC Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Wray NR Wray N R NR Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Medland SE Medland S E SE Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Martin NG Martin N G NG Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Molecular psychiatry
ISOABBREVIATION: Mol. Psychiatry
YEAR: 2017
MONTH: Jul
DAY: 11
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5578
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Mol Psychiatry
COUNTRY: England
ISSNLINKING: 1359-4184
NLMUNIQUEID: 9607835
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
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