Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
28679550
TITLE
Differences in genetic and environmental variation in adult body mass index by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts.
ABSTRACT
Background: Genes and the environment contribute to variation in adult body mass index [BMI (in kg/m(2))], but factors modifying these variance components are poorly understood.Objective: We analyzed genetic and environmental variation in BMI between men and women from young adulthood to old age from the 1940s to the 2000s and between cultural-geographic regions representing high (North America and Australia), moderate (Europe), and low (East Asia) prevalence of obesity.Design: We used genetic structural equation modeling to analyze BMI in twins ≥20 y of age from 40 cohorts representing 20 countries (140,379 complete twin pairs).Results: The heritability of BMI decreased from 0.77 (95% CI: 0.77, 0.78) and 0.75 (95% CI: 0.74, 0.75) in men and women 20-29 y of age to 0.57 (95% CI: 0.54, 0.60) and 0.59 (95% CI: 0.53, 0.65) in men 70-79 y of age and women 80 y of age, respectively. The relative influence of unique environmental factors correspondingly increased. Differences in the sets of genes affecting BMI in men and women increased from 20-29 to 60-69 y of age. Mean BMI and variances in BMI increased from the 1940s to the 2000s and were greatest in North America and Australia, followed by Europe and East Asia. However, heritability estimates were largely similar over measurement years and between regions. There was no evidence of environmental factors shared by co-twins affecting BMI.Conclusions: The heritability of BMI decreased and differences in the sets of genes affecting BMI in men and women increased from young adulthood to old age. The heritability of BMI was largely similar between cultural-geographic regions and measurement years, despite large differences in mean BMI and variances in BMI. Our results show a strong influence of genetic factors on BMI, especially in early adulthood, regardless of the obesity level in the population.
2017 American Society for Nutrition.
DATE PUBLISHED
2017 Jul 05
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2017/01/26
accepted 2017/06/08
entrez 2017/07/07 06:00
pubmed 2017/07/07 06:00
medline 2017/07/07 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Silventoinen K Silventoinen Karri K Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Jelenkovic A Jelenkovic Aline A Department of Genetics, Physical Anthropology, and Animal Physiology, University of the Basque Country, Leioa, Spain.
Sund R Sund Reijo R Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Yokoyama Y Yokoyama Yoshie Y Department of Public Health Nursing, Osaka City University, Osaka, Japan.
Hur YM Hur Yoon-Mi YM Department of Education, Mokpo National University, Jeonnam, South Korea.
Cozen W Cozen Wendy W Norris Comprehensive Cancer Center, and.
Hwang AE Hwang Amie E AE Department of Preventive Medicine, Keck School of Medicine.
Mack TM Mack Thomas M TM Norris Comprehensive Cancer Center, and.
Honda C Honda Chika C Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Inui F Inui Fujio F Faculty of Health Science, Kio University, Nara, Japan.
Iwatani Y Iwatani Yoshinori Y Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Watanabe M Watanabe Mikio M Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Tomizawa R Tomizawa Rie R Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Pietiläinen KH Pietiläinen Kirsi H KH Endocrinology, Abdominal Center, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Rissanen A Rissanen Aila A Endocrinology, Abdominal Center, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Siribaddana SH Siribaddana Sisira H SH Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka.
Hotopf M Hotopf Matthew M National Institute for Health Research Mental Health Biomedical Research Centre, South London and Maudsley National Health Service Foundation Trust, Institute of Psychiatry Psychology and Neuroscience.
Sumathipala A Sumathipala Athula A Research Institute for Primary Care and Health Sciences, School for Primary Care Research, Faculty of Health, Keele University, Staffordshire, United Kingdom.
Rijsdijk F Rijsdijk Fruhling F Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, and.
Tan Q Tan Qihua Q Unit of Epidemiology, Biostatistics, and Biodemography, Departments of Public Health and.
Zhang D Zhang Dongfeng D Department of Public Health, Qingdao University Medical College, Qingdao, China.
Pang Z Pang Zengchang Z Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Piirtola M Piirtola Maarit M Institute for Molecular Medicine, Helsinki, Finland.
Aaltonen S Aaltonen Sari S Public Health, and.
Öncel SY Öncel Sevgi Y SY Department of Statistics, Faculty of Arts and Sciences, Kırıkkale University, Kırıkkale, Turkey.
Aliev F Aliev Fazil F African American Studies.
Rebato E Rebato Esther E Department of Genetics, Physical Anthropology, and Animal Physiology, University of the Basque Country, Leioa, Spain.
Hjelmborg JB Hjelmborg Jacob B JB The Danish Twin Registry.
Christensen K Christensen Kaare K Departments of Clinical Biochemistry and Pharmacology and Clinical Genetics, and.
Skytthe A Skytthe Axel A The Danish Twin Registry.
Kyvik KO Kyvik Kirsten O KO Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark.
Silberg JL Silberg Judy L JL Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, and.
Eaves LJ Eaves Lindon J LJ Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, and.
Cutler TL Cutler Tessa L TL The Australian Twin Registry, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria, Australia.
Ordoñana JR Ordoñana Juan R JR Biomedical Research Institute of Murcia (IMIB)-Arrixaca, Murcia, Spain.
Sánchez-Romera JF Sánchez-Romera Juan F JF Biomedical Research Institute of Murcia (IMIB)-Arrixaca, Murcia, Spain.
Colodro-Conde L Colodro-Conde Lucia L Quantitative Genetics Laboratory and.
Song YM Song Yun-Mi YM Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Yang S Yang Sarah S Institute of Health and Environment, Seoul National University, Seoul, South Korea.
Lee K Lee Kayoung K Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
Franz CE Franz Carol E CE Department of Psychiatry, University of California, San Diego, CA.
Kremen WS Kremen William S WS US Department of Veterans Affairs San Diego Center of Excellence for Stress and Mental Health, La Jolla, CA.
Lyons MJ Lyons Michael J MJ Department of Psychology, Boston University, Boston, MA.
Busjahn A Busjahn Andreas A HealthTwiSt GmbH, Berlin, Germany.
Nelson TL Nelson Tracy L TL Department of Health and Exercise Sciences, Colorado School of Public Health, Colorado State University, Aurora, CO.
Whitfield KE Whitfield Keith E KE Psychology Department, Wayne State University, Detroit, MI.
Kandler C Kandler Christian C Department of Psychology, Bielefeld University, Bielefeld, Germany.
Jang KL Jang Kerry L KL Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
Gatz M Gatz Margaret M Departments of Medical Epidemiology and Biostatistics and.
Butler DA Butler David A DA Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine, Washington, DC.
Stazi MA Stazi Maria A MA Italian National Institute of Health National Center for Epidemiology, Surveillance, and Health Promotion, Rome, Italy.
Fagnani C Fagnani Corrado C Italian National Institute of Health National Center for Epidemiology, Surveillance, and Health Promotion, Rome, Italy.
D'Ippolito C D'Ippolito Cristina C Italian National Institute of Health National Center for Epidemiology, Surveillance, and Health Promotion, Rome, Italy.
Duncan GE Duncan Glen E GE Washington State Twin Registry, Health Sciences, Washington State University, Spokane, WA.
Buchwald D Buchwald Dedra D Washington State Twin Registry, Health Sciences, Washington State University, Spokane, WA.
Martin NG Martin Nicholas G NG Genetic Epidemiology Department, Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Australia.
Medland SE Medland Sarah E SE Genetic Epidemiology Department, Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Australia.
Montgomery GW Montgomery Grant W GW Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Jeong HU Jeong Hoe-Uk HU Department of Education, Mokpo National University, Jeonnam, South Korea.
Swan GE Swan Gary E GE Department of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA.
Krasnow R Krasnow Ruth R Center for Health Sciences, SRI International, Menlo Park, CA.
Magnusson PK Magnusson Patrik Ke PK Departments of Medical Epidemiology and Biostatistics and.
Pedersen NL Pedersen Nancy L NL Departments of Medical Epidemiology and Biostatistics and.
Dahl Aslan AK Dahl Aslan Anna K AK Institute of Gerontology and Aging Research Network, School of Health and Welfare, Jönköping University, Jönköping, Sweden.
McAdams TA McAdams Tom A TA Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, and.
Eley TC Eley Thalia C TC Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, and.
Gregory AM Gregory Alice M AM Department of Psychology, Goldsmiths, University of London, London, United Kingdom.
Tynelius P Tynelius Per P Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Baker LA Baker Laura A LA Department of Psychology, University of Southern California, Los Angeles, CA.
Tuvblad C Tuvblad Catherine C School of Law, Psychology, and Social Work, Örebro University, Örebro, Sweden.
Bayasgalan G Bayasgalan Gombojav G Healthy Twin Association of Mongolia, Ulaanbaatar, Mongolia.
Narandalai D Narandalai Danshiitsoodol D Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Spector TD Spector Timothy D TD Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
Mangino M Mangino Massimo M National Institute for Health Research Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London, United Kingdom.
Lachance G Lachance Genevieve G Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
Burt SA Burt S Alexandra SA Michigan State University, East Lansing, Michigan.
Klump KL Klump Kelly L KL Michigan State University, East Lansing, Michigan.
Harris JR Harris Jennifer R JR Norwegian Institute of Public Health, Oslo, Norway.
Brandt I Brandt Ingunn I Norwegian Institute of Public Health, Oslo, Norway.
Nilsen TS Nilsen Thomas S TS Norwegian Institute of Public Health, Oslo, Norway.
Krueger RF Krueger Robert F RF Department of Psychology, University of Minnesota, Minneapolis, MN.
McGue M McGue Matt M Department of Psychology, University of Minnesota, Minneapolis, MN.
Pahlen S Pahlen Shandell S Department of Psychology, University of Minnesota, Minneapolis, MN.
Corley RP Corley Robin P RP Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado.
Huibregtse BM Huibregtse Brooke M BM Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado.
Bartels M Bartels Meike M Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
van Beijsterveldt CE van Beijsterveldt Catharina Em CE Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Willemsen G Willemsen Gonneke G Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Goldberg JH Goldberg Jack H JH Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA.
Rasmussen F Rasmussen Finn F Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Tarnoki AD Tarnoki Adam D AD Hungarian Twin Registry, Budapest, Hungary.
Tarnoki DL Tarnoki David L DL Hungarian Twin Registry, Budapest, Hungary.
Derom CA Derom Catherine A CA Department of Obstetrics and Gynaecology, Ghent University Hospitals, Ghent, Belgium.
Vlietinck RF Vlietinck Robert F RF Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Loos RJ Loos Ruth Jf RJ Charles Bronfman Institute for Personalized Medicine, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Hopper JL Hopper John L JL The Australian Twin Registry, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria, Australia.
Sung J Sung Joohon J Institute of Health and Environment, Seoul National University, Seoul, South Korea.
Maes HH Maes Hermine H HH Departments of Human and Molecular Genetics and Psychiatry, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA.
Turkheimer E Turkheimer Eric E Department of Psychology, University of Virginia, Charlottesville, VA.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Sørensen TI Sørensen Thorkild Ia TI Department of Clinical Epidemiology, Bispebjerg and Frederiksberg Hospitals, Copenhagen, Denmark.
Kaprio J Kaprio Jaakko J Institute for Molecular Medicine, Helsinki, Finland.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: The American journal of clinical nutrition
ISOABBREVIATION: Am. J. Clin. Nutr.
YEAR: 2017
MONTH: Jul
DAY: 05
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1938-3207
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Clin Nutr
COUNTRY: United States
ISSNLINKING: 0002-9165
NLMUNIQUEID: 0376027
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
BMI
adults
genetics
international comparisons
twins
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's