Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
2861087
TITLE
Individual differences in plasma ALT, AST and GGT: contributions of genetic and environmental factors, including alcohol consumption.
ABSTRACT
The causes of individuality of the plasma enzymes alanine aminotransferase (ALT; EC 2.6.1.2), aspartate aminotransferase (AST; EC 2.6.1.1) and gamma-glutamyl transferase (GGT; EC 2.3.2.2) were investigated in a study of 206 pairs of twins. Between-person variance was greater in men than women, while within-person variation was similar in both sexes. Plasma ALT and AST levels were affected by genetic factors, while GGT was affected by some environmental factor shared by co-twins. In the men, alcohol intake had a significant but small effect on all three enzyme levels, and since alcohol consumption was highly heritable, this appeared as a genetic influence on enzyme activities. The major factors involved in the observed correlations between these enzymes were a non-shared environmental factor other than alcohol affecting ALT, AST and GGT, and a genetic factor affecting only ALT and AST.
DATE PUBLISHED
1985
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1985/01/01
medline 1985/01/01 00:01
entrez 1985/01/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Whitfield JB Whitfield J B JB
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 33
ISSUE: 2
TITLE: Enzyme
ISOABBREVIATION: Enzyme
YEAR: 1985
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0013-9432
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Enzyme
COUNTRY: SWITZERLAND
ISSNLINKING: 0013-9432
NLMUNIQUEID: 1262265
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Alanine Transaminase genetics
Alcohol Drinking genetics
Aspartate Aminotransferases genetics
Environment genetics
Female genetics
Genetic Variation genetics
Humans genetics
Male genetics
Pregnancy genetics
Sex Factors genetics
Twins genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
gamma-Glutamyltransferase genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
EC 2.3.2.2 gamma-Glutamyltransferase
EC 2.6.1.1 Aspartate Aminotransferases
EC 2.6.1.2 Alanine Transaminase
OTHER ID's