Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
28584286
TITLE
Genome-wide meta-analysis of cognitive empathy: heritability, and correlates with sex, neuropsychiatric conditions and cognition.
ABSTRACT
We conducted a genome-wide meta-analysis of cognitive empathy using the 'Reading the Mind in the Eyes' Test (Eyes Test) in 88,056 research volunteers of European Ancestry (44,574 females and 43,482 males) from 23andMe Inc., and an additional 1497 research volunteers of European Ancestry (891 females and 606 males) from the Brisbane Longitudinal Twin Study. We confirmed a female advantage on the Eyes Test (Cohen's d=0.21, P<2.2 × 10(-16)), and identified a locus in 3p26.1 that is associated with scores on the Eyes Test in females (rs7641347, Pmeta=1.58 × 10(-8)). Common single nucleotide polymorphisms explained 5.8% (95% CI: 4.5%-7.2%; P=1.00 × 10(-17)) of the total trait variance in both sexes, and we identified a twin heritability of 28% (95% CI: 13%-42%). Finally, we identified significant genetic correlation between the Eyes Test and anorexia nervosa, openness (NEO-Five Factor Inventory), and different measures of educational attainment and cognitive aptitude.Molecular Psychiatry advance online publication, 6 June 2017; doi:10.1038/mp.2017.122.
DATE PUBLISHED
2017 Jun 06
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/11/19
revised 2017/04/08
accepted 2017/04/12
entrez 2017/06/07 06:00
pubmed 2017/06/07 06:00
medline 2017/06/07 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Warrier V Warrier V V Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridgeshire, UK.
Grasby KL Grasby K L KL QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Uzefovsky F Uzefovsky F F Department of Psychology, Ben Gurion University of the Negev, Be'er Sheva, Israel.
Toro R Toro R R Institut Pasteur, Paris, France.
Smith P Smith P P Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridgeshire, UK.
Chakrabarti B Chakrabarti B B Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.
Khadake J Khadake J J NIHR Cambridge BioResource, Cambridge University and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Mawbey-Adamson E Mawbey-Adamson E E NIHR Cambridge BioResource, Cambridge University and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Litterman N Litterman N N 23andMe Inc., Mountain View, CA, USA.
Hottenga JJ Hottenga J-J JJ Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Lubke G Lubke G G Department of Psychology, University of Notre Dame, South Bend, IN, USA.
Boomsma DI Boomsma D I DI Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Martin NG Martin N G NG QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Hatemi PK Hatemi P K PK Political Science, Microbiology and Biochemistry, Pennsylvania State University, University Park, PA, USA.
Medland SE Medland S E SE QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Hinds DA Hinds D A DA 23andMe Inc., Mountain View, CA, USA.
Bourgeron T Bourgeron T T Institut Pasteur, Paris, France.
Baron-Cohen S Baron-Cohen S S CLASS Clinic, Cambridgeshire and Peterborough NHS Foundation Trust (CPFT), Cambridgeshire, UK.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Molecular psychiatry
ISOABBREVIATION: Mol. Psychiatry
YEAR: 2017
MONTH: Jun
DAY: 06
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5578
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Mol Psychiatry
COUNTRY: England
ISSNLINKING: 1359-4184
NLMUNIQUEID: 9607835
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
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