Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
28582860
TITLE
No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease.
ABSTRACT
Iron deposition in the brain is a prominent feature of Alzheimer's disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations are causal: do elevated or depleted iron levels throughout life have an effect on AD risk? We evaluate the effects of peripheral iron on AD risk using a genetic profile score approach by testing whether variants affecting iron, transferrin, or ferritin levels selected from GWAS meta-analysis of approximately 24,000 individuals are also associated with AD risk in an independent case-control cohort (n∼10,000). Conversely, we test whether AD risk variants from a GWAS meta-analysis of approximately 54,000 account for any variance in iron measures (n∼9,000). We do not identify a genetic relationship, suggesting that peripheral iron is not causal in the initiation of AD pathology.
DATE PUBLISHED
2017
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2017/06/07 06:00
medline 2017/06/07 06:00
entrez 2017/06/07 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Lupton MK Lupton Michelle K MK QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Benyamin B Benyamin Beben B Queensland Brain Institute, University of Queensland, Brisbane, Australia.
Proitsi P Proitsi Petroula P Institute of Psychiatry Psychology and Neuroscience, Kings College London, UK.
Nyholt DR Nyholt Dale R DR Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Ferreira MA Ferreira Manuel A MA QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Montgomery GW Montgomery Grant W GW Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Heath AC Heath Andrew C AC Washington University School of Medicine, StLouis, MO, USA.
Madden PA Madden Pamela A PA Washington University School of Medicine, StLouis, MO, USA.
Medland SE Medland Sarah E SE QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Gordon SD Gordon Scott D SD QIMR Berghofer Medical Research Institute, Brisbane, Australia.
GERAD1 Consortium
Alzheimer’s Disease Neuroimaging Initiative
Lovestone S Lovestone Simon S Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
Tsolaki M Tsolaki Magda M Memory and Dementia Centre, 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Kloszewska I Kloszewska Iwona I Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland.
Soininen H Soininen Hilkka H Department of Neurology, University of EasternFinland and Kuopio University Hospital, Kuopio, Finland.
Mecocci P Mecocci Patrizia P Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
Vellas B Vellas Bruno B Gerontopole, CHU, UMR INSERM 1027, University ofToulouse, France.
Powell JF Powell John F JF Institute of Psychiatry Psychology and Neuroscience, Kings College London, UK.
Bush AI Bush Ashley I AI Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.
Wright MJ Wright Margaret J MJ Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Whitfield JB Whitfield John B JB QIMR Berghofer Medical Research Institute, Brisbane, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 59
ISSUE: 1
TITLE: Journal of Alzheimer's disease : JAD
ISOABBREVIATION: J. Alzheimers Dis.
YEAR: 2017
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1875-8908
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Alzheimers Dis
COUNTRY: Netherlands
ISSNLINKING: 1387-2877
NLMUNIQUEID: 9814863
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Alzheimer’s disease
apolipoproteins E
dementia
ferritin
genetic profile scores
genome-wide association study
iron
population genetics
transferrin
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's