Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
28465822
TITLE
Does the sex of one's co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
The comparison of traits in twins from opposite-sex (OS) and same-sex (SS) dizygotic twin pairs is considered a proxy measure of prenatal hormone exposure. To examine possible prenatal hormonal influences on anthropometric traits, we compared mean height, body mass index (BMI), and the prevalence of being overweight or obese between men and women from OS and SS dizygotic twin pairs.
METHODS NlmCategory: METHODS
The data were derived from the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) database, and included 68,494 SS and 53,808 OS dizygotic twin individuals above the age of 20 years from 31 twin cohorts representing 19 countries. Zygosity was determined by questionnaires or DNA genotyping depending on the study. Multiple regression and logistic regression models adjusted for cohort, age, and birth year with the twin type as a predictor were carried out to compare height and BMI in twins from OS pairs with those from SS pairs and to calculate the adjusted odds ratios and 95% confidence intervals for being overweight or obese.
RESULTS NlmCategory: RESULTS
OS females were, on average, 0.31 cm (95% confidence interval (CI) 0.20, 0.41) taller than SS females. OS males were also, on average, taller than SS males, but this difference was only 0.14 cm (95% CI 0.02, 0.27). Mean BMI and the prevalence of overweight or obesity did not differ between males and females from SS and OS twin pairs. The statistically significant differences between OS and SS twins for height were small and appeared to reflect our large sample size rather than meaningful differences of public health relevance.
CONCLUSIONS NlmCategory: CONCLUSIONS
We found no evidence to support the hypothesis that prenatal hormonal exposure or postnatal socialization (i.e., having grown up with a twin of the opposite sex) has a major impact on height and BMI in adulthood.
DATE PUBLISHED
2017
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/12/23
accepted 2017/04/05
entrez 2017/05/04 06:00
pubmed 2017/05/04 06:00
medline 2017/05/04 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Bogl LH Bogl Leonie H LH Department of Public Health, University of Helsinki, Helsinki, Finland.
Jelenkovic A Jelenkovic Aline A Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Vuoksimaa E Vuoksimaa Eero E Institute for Molecular Medicine FIMM, University of Helsinki, P.O. Box 20, FI-00014 Helsinki, Finland.
Ahrenfeldt L Ahrenfeldt Linda L Department of Public Health, Epidemiology, Biostatistics & Biodemography, The Danish Twin Registry, University of Southern Denmark, Odense, Denmark.
Pietiläinen KH Pietiläinen Kirsi H KH Endocrinology, Abdominal Center, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Stazi MA Stazi Maria A MA Istituto Superiore di Sanità-National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
Fagnani C Fagnani Corrado C Istituto Superiore di Sanità-National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
D'Ippolito C D'Ippolito Cristina C Istituto Superiore di Sanità-National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
Hur YM Hur Yoon-Mi YM Department of Education, Mokpo National University, Jeonnam, South Korea.
Jeong HU Jeong Hoe-Uk HU Department of Education, Mokpo National University, Jeonnam, South Korea.
Silberg JL Silberg Judy L JL Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA USA.
Eaves LJ Eaves Lindon J LJ Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA USA.
Maes HH Maes Hermine H HH Department of Human and Molecular Genetics, Psychiatry & Massey Cancer Center, Virginia Commonwealth University, Richmond, VA USA.
Bayasgalan G Bayasgalan Gombojav G Healthy Twin Association of Mongolia, Ulaanbaatar, Mongolia.
Narandalai D Narandalai Danshiitsoodol D Healthy Twin Association of Mongolia, Ulaanbaatar, Mongolia.
Cutler TL Cutler Tessa L TL The Australian Twin Registry, Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC Australia.
Kandler C Kandler Christian C Department of Psychology, Medical School Berlin, Berlin, Germany.
Jang KL Jang Kerry L KL Department of Psychiatry, University of British Columbia, Vancouver, BC Canada.
Christensen K Christensen Kaare K Department of Clinical Biochemistry and Pharmacology and Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Skytthe A Skytthe Axel A Department of Public Health, Epidemiology, Biostatistics & Biodemography, The Danish Twin Registry, University of Southern Denmark, Odense, Denmark.
Kyvik KO Kyvik Kirsten O KO Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark.
Cozen W Cozen Wendy W USC Norris Comprehensive Cancer Center, Los Angeles, CA USA.
Hwang AE Hwang Amie E AE Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA USA.
Mack TM Mack Thomas M TM USC Norris Comprehensive Cancer Center, Los Angeles, CA USA.
Derom CA Derom Catherine A CA Department of Obstetrics and Gynaecology, Ghent University Hospitals, Ghent, Belgium.
Vlietinck RF Vlietinck Robert F RF Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Nelson TL Nelson Tracy L TL Department of Health and Exercise Sciences and Colorado School of Public Health, Colorado State University, Fort Collins, USA.
Whitfield KE Whitfield Keith E KE Psychology and Neuroscience, Duke University, Durham, NC USA.
Corley RP Corley Robin P RP Institute for Behavioral Genetics, University of Colorado, Boulder, CO USA.
Huibregtse BM Huibregtse Brooke M BM Institute for Behavioral Genetics, University of Colorado, Boulder, CO USA.
McAdams TA McAdams Tom A TA Institute of Psychiatry, Psychology & Neuroscience, MRC Social, Genetic & Developmental Psychiatry Centre, King's College London, London, UK.
Eley TC Eley Thalia C TC Institute of Psychiatry, Psychology & Neuroscience, MRC Social, Genetic & Developmental Psychiatry Centre, King's College London, London, UK.
Gregory AM Gregory Alice M AM Department of Psychology, Goldsmiths, University of London, London, UK.
Krueger RF Krueger Robert F RF Department of Psychology, University of Minnesota, Minneapolis, MN USA.
McGue M McGue Matt M Department of Psychology, University of Minnesota, Minneapolis, MN USA.
Pahlen S Pahlen Shandell S Department of Psychology, University of Minnesota, Minneapolis, MN USA.
Willemsen G Willemsen Gonneke G Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Bartels M Bartels Meike M Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
van Beijsterveldt TCEM van Beijsterveldt Toos C E M TCEM Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Pang Z Pang Zengchang Z Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Tan Q Tan Qihua Q Institute of Public Health, Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark.
Zhang D Zhang Dongfeng D Department of Public Health, Qingdao University Medical College, Qingdao, China.
Martin NG Martin Nicholas G NG Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Medland SE Medland Sarah E SE Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Montgomery GW Montgomery Grant W GW Molecular Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Hjelmborg JVB Hjelmborg Jacob V B JVB Department of Public Health, Epidemiology, Biostatistics & Biodemography, The Danish Twin Registry, University of Southern Denmark, Odense, Denmark.
Rebato E Rebato Esther E Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Swan GE Swan Gary E GE Department of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA USA.
Krasnow R Krasnow Ruth R Center for Health Sciences, SRI International, Menlo Park, CA USA.
Busjahn A Busjahn Andreas A HealthTwiSt GmbH, Berlin, Germany.
Lichtenstein P Lichtenstein Paul P Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Öncel SY Öncel Sevgi Y SY Department of Statistics, Faculty of Arts and Sciences, Kırıkkale University, Kırıkkale, Turkey.
Aliev F Aliev Fazil F Faculty of Business, Karabuk University, Karabuk, Turkey.
Baker LA Baker Laura A LA Department of Psychology, University of Southern California, Los Angeles, CA USA.
Tuvblad C Tuvblad Catherine C School of Law, Psychology and Social Work, Örebro University, Örebro, Sweden.
Siribaddana SH Siribaddana Sisira H SH Faculty of Medicine & Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka.
Hotopf M Hotopf Matthew M Institute of Psychiatry Psychology and Neuroscience, NIHR Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust and King's College London, London, UK.
Sumathipala A Sumathipala Athula A Research Institute for Primary Care and Health Sciences, School for Primary Care Research (SPCR), Faculty of Health, Keele University, Staffordshire, UK.
Rijsdijk F Rijsdijk Fruhling F Institute of Psychiatry, Psychology & Neuroscience, MRC Social, Genetic & Developmental Psychiatry Centre, King's College London, London, UK.
Magnusson PKE Magnusson Patrik K E PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Aslan AKD Aslan Anna K Dahl AKD Institute of Gerontology and Aging Research Network-Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Jönköping, Sweden.
Ordoñana JR Ordoñana Juan R JR IMIB-Arrixaca, Murcia, Spain.
Sánchez-Romera JF Sánchez-Romera Juan F JF IMIB-Arrixaca, Murcia, Spain.
Colodro-Conde L Colodro-Conde Lucia L QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Duncan GE Duncan Glen E GE Washington State Twin Registry, Washington State University-Health Sciences Spokane, Spokane, WA USA.
Buchwald D Buchwald Dedra D Washington State Twin Registry, Washington State University-Health Sciences Spokane, Spokane, WA USA.
Tarnoki AD Tarnoki Adam D AD Hungarian Twin Registry, Budapest, Hungary.
Tarnoki DL Tarnoki David L DL Hungarian Twin Registry, Budapest, Hungary.
Yokoyama Y Yokoyama Yoshie Y Department of Public Health Nursing, Osaka City University, Osaka, Japan.
Hopper JL Hopper John L JL Department of Epidemiology, School of Public Health, Seoul National University, Seoul, South Korea.
Loos RJF Loos Ruth J F RJF The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY USA.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Sørensen TIA Sørensen Thorkild I A TIA Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, Copenhagen, The Capital Region Denmark.
Silventoinen K Silventoinen Karri K Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Kaprio J Kaprio Jaakko J Department of Public Health, University of Helsinki, Helsinki, Finland.
INVESTIGATORS
JOURNAL
VOLUME: 8
ISSUE:
TITLE: Biology of sex differences
ISOABBREVIATION: Biol Sex Differ
YEAR: 2017
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2042-6410
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Biol Sex Differ
COUNTRY: England
ISSNLINKING: 2042-6410
NLMUNIQUEID: 101548963
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
T32 DA017637 NIDA NIH HHS United States
R01 ES015150 NIEHS NIH HHS United States
R01 AA009203 NIAAA NIH HHS United States
RC2 HL103416 NHLBI NIH HHS United States
R01 HD010333 NICHD NIH HHS United States
P01 AG008761 NIA NIH HHS United States
K05 AA000145 NIAAA NIH HHS United States
R01 AA012502 NIAAA NIH HHS United States
R01 MH058354 NIMH NIH HHS United States
P60 DA011015 NIDA NIH HHS United States
R37 AA012502 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Body mass index
CODATwins
Height
Opposite-sex twins
Prenatal hormone exposure
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's