Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
28378620
TITLE
The Anorexia Nervosa Genetics Initiative: Study description and sample characteristics of the Australian and New Zealand arm.
ABSTRACT
OBJECTIVES NlmCategory: OBJECTIVE
Anorexia nervosa is a severe psychiatric disorder with high mortality rates. While its aetiology is poorly understood, there is evidence of a significant genetic component. The Anorexia Nervosa Genetics Initiative is an international collaboration which aims to understand the genetic basis of the disorder. This paper describes the recruitment and characteristics of the Australasian Anorexia Nervosa Genetics Initiative sample, the largest sample of individuals with anorexia nervosa ever assembled across Australia and New Zealand.
METHODS NlmCategory: METHODS
Participants completed an online questionnaire based on the Structured Clinical Interview Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) eating disorders section. Participants who met specified case criteria for lifetime anorexia nervosa were requested to provide a DNA sample for genetic analysis.
RESULTS NlmCategory: RESULTS
Overall, the study recruited 3414 Australians and 543 New Zealanders meeting the lifetime anorexia nervosa case criteria by using a variety of conventional and social media recruitment methods. At the time of questionnaire completion, 28% had a body mass index ⩽ 18.5 kg/m(2). Fasting and exercise were the most commonly employed methods of weight control, and were associated with the youngest reported ages of onset. At the time of the study, 32% of participants meeting lifetime anorexia nervosa case criteria were under the care of a medical practitioner; those with current body mass index < 18.5 kg/m(2) were more likely to be currently receiving medical care (56%) than those with current body mass index ⩾ 18.5 kg/m(2) (23%). Professional treatment for eating disorders was most likely to have been received from general practitioners (45% of study participants), dietitians (42%) and outpatient programmes (42%).
CONCLUSIONS NlmCategory: CONCLUSIONS
This study was effective in assembling the largest community sample of people with lifetime anorexia nervosa in Australia and New Zealand to date. The proportion of people with anorexia nervosa currently receiving medical care, and the most common sources of treatment accessed, indicates the importance of training for general practitioners and dietitians in treating anorexia nervosa.
DATE PUBLISHED
2017 Apr 01
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2017/04/06 06:00
pubmed 2017/04/06 06:00
medline 2017/04/06 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Kirk KM Kirk Katherine M KM 1 Genetic Epidemiology Laboratory, QIMR Berghofer Institute of Medical Research, Brisbane, QLD, Australia.
Martin FC Martin Felicity C FC 1 Genetic Epidemiology Laboratory, QIMR Berghofer Institute of Medical Research, Brisbane, QLD, Australia.
Mao A Mao Amy A 2 Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.
Parker R Parker Richard R 1 Genetic Epidemiology Laboratory, QIMR Berghofer Institute of Medical Research, Brisbane, QLD, Australia.
Maguire S Maguire Sarah S 3 University of Sydney, Sydney, NSW, Australia.
Thornton LM Thornton Laura M LM 4 University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Zhu G Zhu Gu G 1 Genetic Epidemiology Laboratory, QIMR Berghofer Institute of Medical Research, Brisbane, QLD, Australia.
McAloney K McAloney Kerrie K 1 Genetic Epidemiology Laboratory, QIMR Berghofer Institute of Medical Research, Brisbane, QLD, Australia.
Freeman JL Freeman Jeremy L JL 5 Australia & New Zealand Academy for Eating Disorders, Sydney, NSW, Australia.
Hay P Hay Phillipa P 6 Western Sydney University, Sydney, NSW, Australia.
Madden S Madden Sloane S 7 The Sydney Children's Hospital Network, Sydney, NSW, Australia.
Morgan C Morgan Christine C 8 The Butterfly Foundation, Sydney, NSW, Australia.
Russell J Russell Janice J 3 University of Sydney, Sydney, NSW, Australia.
Sawyer SM Sawyer Susan M SM 9 The Royal Children's Hospital, Melbourne, VIC, Australia.
Hughes EK Hughes Elizabeth K EK 9 The Royal Children's Hospital, Melbourne, VIC, Australia.
Fairweather-Schmidt AK Fairweather-Schmidt A Kate AK 10 Flinders University, Adelaide, SA, Australia.
Fursland A Fursland Anthea A 12 Curtin University, Perth, WA, Australia.
McCormack J McCormack Julie J 13 Princess Margaret Hospital for Children, Perth, WA, Australia.
Wagg F Wagg Fiona F 14 Royal Hobart Hospital, Hobart, TAS, Australia.
Jordan J Jordan Jennifer J 15 University of Otago, Christchurch, New Zealand.
Kennedy MA Kennedy Martin A MA 15 University of Otago, Christchurch, New Zealand.
Ward W Ward Warren W 16 School of Medicine, University of Queensland, Brisbane, QLD, Australia.
Wade TD Wade Tracey D TD 10 Flinders University, Adelaide, SA, Australia.
Bulik CM Bulik Cynthia M CM 17 Karolinska Institutet, Stockholm, Sweden.
Martin NG Martin Nicholas G NG 1 Genetic Epidemiology Laboratory, QIMR Berghofer Institute of Medical Research, Brisbane, QLD, Australia.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: The Australian and New Zealand journal of psychiatry
ISOABBREVIATION: Aust N Z J Psychiatry
YEAR: 2017
MONTH: Apr
DAY: 01
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1440-1614
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Aust N Z J Psychiatry
COUNTRY: England
ISSNLINKING: 0004-8674
NLMUNIQUEID: 0111052
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Anorexia nervosa
eating disorder
genome-wide association study
recruitment
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's