Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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28241208
TITLE
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
ABSTRACT
Importance NlmCategory: UNASSIGNED
The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation.
Objective NlmCategory: UNASSIGNED
To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases.
Data Sources NlmCategory: UNASSIGNED
Genomewide association studies (GWAS) published up to January 15, 2015.
Study Selection NlmCategory: UNASSIGNED
GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis of preexisting diseases. Of 163 GWAS of noncommunicable diseases identified, summary data from 103 were available.
Data Extraction and Synthesis NlmCategory: UNASSIGNED
Summary association statistics for single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population.
Main Outcomes and Measures NlmCategory: UNASSIGNED
Odds ratios (ORs) and 95% confidence intervals (CIs) for disease per standard deviation (SD) higher telomere length due to germline genetic variation.
Results NlmCategory: UNASSIGNED
Summary data were available for 35 cancers and 48 non-neoplastic diseases, corresponding to 420 081 cases (median cases, 2526 per disease) and 1 093 105 controls (median, 6789 per disease). Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers. The strongest associations (ORs [95% CIs] per 1-SD change in genetically increased telomere length) were observed for glioma, 5.27 (3.15-8.81); serous low-malignant-potential ovarian cancer, 4.35 (2.39-7.94); lung adenocarcinoma, 3.19 (2.40-4.22); neuroblastoma, 2.98 (1.92-4.62); bladder cancer, 2.19 (1.32-3.66); melanoma, 1.87 (1.55-2.26); testicular cancer, 1.76 (1.02-3.04); kidney cancer, 1.55 (1.08-2.23); and endometrial cancer, 1.31 (1.07-1.61). Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division. There was generally little evidence of association between genetically increased telomere length and risk of psychiatric, autoimmune, inflammatory, diabetic, and other non-neoplastic diseases, except for coronary heart disease (OR, 0.78 [95% CI, 0.67-0.90]), abdominal aortic aneurysm (OR, 0.63 [95% CI, 0.49-0.81]), celiac disease (OR, 0.42 [95% CI, 0.28-0.61]) and interstitial lung disease (OR, 0.09 [95% CI, 0.05-0.15]).
Conclusions and Relevance NlmCategory: UNASSIGNED
It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases.
DATE PUBLISHED
2017 Feb 23
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2017/02/28 06:00
pubmed 2017/02/28 06:00
medline 2017/02/28 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Telomeres Mendelian Randomization Collaboration
Haycock PC Haycock Philip C PC MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Burgess S Burgess Stephen S Department of Public Health and Primary Care, University of Cambridge, Cambridge, England.
Nounu A Nounu Aayah A MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Zheng J Zheng Jie J MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Okoli GN Okoli George N GN School of Social and Community Medicine, University of Bristol, Bristol, England.
Bowden J Bowden Jack J MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Wade KH Wade Kaitlin Hazel KH MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Timpson NJ Timpson Nicholas J NJ MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Evans DM Evans David M DM MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England4University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.
Willeit P Willeit Peter P Department of Public Health and Primary Care, University of Cambridge, Cambridge, England5Department of Neurology, Innsbruck Medical University, Austria.
Aviv A Aviv Abraham A Center of Human Development and Aging, Department of Pediatrics, New Jersey Medical School, Rutgers, The State University of New Jersey.
Gaunt TR Gaunt Tom R TR MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Hemani G Hemani Gibran G MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Mangino M Mangino Massimo M Department of Twin Research and Genetic Epidemiology, King's College London, London England8NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, England.
Ellis HP Ellis Hayley Patricia HP Brain Tumour Research Group, Institute of Clinical Neuroscience, Learning and Research Building, Southmead Hospital, University of Bristol.
Kurian KM Kurian Kathreena M KM Brain Tumour Research Group, Institute of Clinical Neuroscience, Learning and Research Building, Southmead Hospital, University of Bristol.
Pooley KA Pooley Karen A KA Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England.
Eeles RA Eeles Rosalind A RA The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, England.
Lee JE Lee Jeffrey E JE Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston.
Fang S Fang Shenying S Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston.
Chen WV Chen Wei V WV Department of Clinical Applications & Support, The University of Texas MD Anderson Cancer Center, Houston.
Law MH Law Matthew H MH Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Bowdler LM Bowdler Lisa M LM QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Iles MM Iles Mark M MM Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, England.
Yang Q Yang Qiong Q Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Worrall BB Worrall Bradford B BB Departments of Neurology and Public Health Sciences, University of Virginia Charlottesville, Virginia.
Markus HS Markus Hugh Stephen HS Department of Clinical Neurosciences, University of Cambridge, England.
Hung RJ Hung Rayjean J RJ Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada21Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Amos CI Amos Chris I CI Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.
Spurdle AB Spurdle Amanda B AB Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Thompson DJ Thompson Deborah J DJ Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England.
O'Mara TA O'Mara Tracy A TA Genetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Wolpin B Wolpin Brian B Dana-Farber Cancer Institute, Boston, Massachusetts.
Amundadottir L Amundadottir Laufey L Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Stolzenberg-Solomon R Stolzenberg-Solomon Rachael R Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Trichopoulou A Trichopoulou Antonia A Hellenic Health Foundation, Athens, Greece28WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.
Onland-Moret NC Onland-Moret N Charlotte NC Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands.
Lund E Lund Eiliv E Institute of Community Medicine, UiT The Arctic University of Norway, Tromso, Norway.
Duell EJ Duell Eric J EJ Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, Barcelona, Spain.
Canzian F Canzian Federico F Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Severi G Severi Gianluca G Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France34Institut Gustave Roussy, Villejuif, France35Human Genetics Foundation (HuGeF), Torino, Italy36Cancer Council Victoria and University of Melbourne, Melbourne, Australia.
Overvad K Overvad Kim K Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.
Gunter MJ Gunter Marc J MJ School of Public Health, Imperial College London, London, England.
Tumino R Tumino Rosario R Cancer Registry, Azienda Ospedaliera "Civile M.P. Arezzo," Ragusa, Italy.
Svenson U Svenson Ulrika U Department of Medical Biosciences, Umea University, Umea, Sweden.
van Rij A van Rij Andre A Surgery Department, University of Otago, Dunedin, New Zealand.
Baas AF Baas Annette F AF Department of Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
Bown MJ Bown Matthew J MJ Department of Cardiovascular Sciences and the NIHR Leicester, Cardiovascular Biomedical Research Unit, University of Leicester, Glenfield Hospital, Leicester, England.
Samani NJ Samani Nilesh J NJ Department of Cardiovascular Sciences and the NIHR Leicester, Cardiovascular Biomedical Research Unit, University of Leicester, Glenfield Hospital, Leicester, England.
van t'Hof FN van t'Hof Femke N G FN Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands.
Tromp G Tromp Gerard G Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa46The Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, Pennsylvania.
Jones GT Jones Gregory T GT Surgery Department, University of Otago, Dunedin, New Zealand.
Kuivaniemi H Kuivaniemi Helena H Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa46The Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, Pennsylvania.
Elmore JR Elmore James R JR Department of Vascular and Endovascular Surgery, Geisinger Health System, Danville, Pennsylvania.
Johansson M Johansson Mattias M Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
Mckay J Mckay James J Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France.
Scelo G Scelo Ghislaine G Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
Carreras-Torres R Carreras-Torres Robert R Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
Gaborieau V Gaborieau Valerie V Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
Brennan P Brennan Paul P Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
Bracci PM Bracci Paige M PM Department of Epidemiology and Biostatistics, University of California San Francisco.
Neale RE Neale Rachel E RE QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Olson SH Olson Sara H SH Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Gallinger S Gallinger Steven S Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
Li D Li Donghui D Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston.
Petersen GM Petersen Gloria M GM Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.
Risch HA Risch Harvey A HA Yale School of Public Health, Yale School of Medicine, and Yale Cancer Center, New Haven, Connecticut.
Klein AP Klein Alison P AP Departments of Oncology, Pathology and Epidemiology, Johns Hopkins School of Medicine, Baltimore, Maryland.
Han J Han Jiali J Department of Epidemiology, Fairbanks School of Public Health, Indiana University, Indianapolis57Indiana University Melvin and Bren Simon Cancer Center, Indianapolis.
Abnet CC Abnet Christian C CC Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Freedman ND Freedman Neal D ND Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Taylor PR Taylor Philip R PR Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Maris JM Maris John M JM Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania.
Aben KK Aben Katja K KK Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands61Netherlands Comprehensive Cancer Organization, Utrecht, The Netherlands.
Kiemeney LA Kiemeney Lambertus A LA Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Vermeulen SH Vermeulen Sita H SH Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Wiencke JK Wiencke John K JK Department of Neurological Surgery, University of California, San Francisco, San Francisco, California63Institute of Human Genetics, University of California, San Francisco, San Francisco, California.
Walsh KM Walsh Kyle M KM Department of Neurological Surgery, University of California, San Francisco, San Francisco, California63Institute of Human Genetics, University of California, San Francisco, San Francisco, California.
Wrensch M Wrensch Margaret M Department of Neurological Surgery, University of California, San Francisco, San Francisco, California63Institute of Human Genetics, University of California, San Francisco, San Francisco, California.
Rice T Rice Terri T Department of Neurological Surgery, University of California, San Francisco, San Francisco, California.
Turnbull C Turnbull Clare C The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, England64William Harvey Research Institute, Queen Mary University, London, England.
Litchfield K Litchfield Kevin K Division of Genetics and Epidemiology, The Institute of Cancer Research, London, England.
Paternoster L Paternoster Lavinia L MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Standl M Standl Marie M Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Abecasis GR Abecasis Gonçalo R GR Department of Biostatistics, University of Michigan, Ann Arbor.
SanGiovanni JP SanGiovanni John Paul JP National Institute of Alcohol Abuse and Alcoholism, Laboratory of Membrane Biophysics and Biochemistry, Section on Nutritional Neuroscience, Bethesda, Maryland69Department of Biochemistry and Molecular and Cellular Biology, Georgetown School of Medicine, Washington, DC.
Li Y Li Yong Y Division of Genetic Epidemiology, Institute for Medical Biometry and Statistics, Faculty of Medicine, and Medical Centre, University of Freiburg, Freiburg, Germany.
Mijatovic V Mijatovic Vladan V Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.
Sapkota Y Sapkota Yadav Y QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Low SK Low Siew-Kee SK Laboratory of Statistical Analysis, Centre for Integrative Medical Sciences, The Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan.
Zondervan KT Zondervan Krina T KT Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, England74Nuffield Department of Obstetrics and Gynecology, University of Oxford, John Radcliffe Hospital, Oxford, England.
Montgomery GW Montgomery Grant W GW QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Nyholt DR Nyholt Dale R DR QIMR Berghofer Medical Research Institute, Brisbane, Australia75Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
van Heel DA van Heel David A DA Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, England.
Hunt K Hunt Karen K Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, England.
Arking DE Arking Dan E DE McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Ashar FN Ashar Foram N FN McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Sotoodehnia N Sotoodehnia Nona N Division of Cardiology and Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington.
Woo D Woo Daniel D University of Cincinnati College of Medicine, Department of Neurology, Cincinnati, Ohio.
Rosand J Rosand Jonathan J Massachusetts General Hospital, Neurology, Center for Human Genetic Research, Boston, Massachusetts.
Comeau ME Comeau Mary E ME Center for Public Health Genomics, Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Brown WM Brown W Mark WM Center for Public Health Genomics, Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Silverman EK Silverman Edwin K EK Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Hokanson JE Hokanson John E JE Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Cho MH Cho Michael H MH Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Hui J Hui Jennie J Busselton Population Medical Research Institute Inc, Sir Charles Gairdner Hospital, Perth, Australia85PathWest Laboratory Medicine of Western Australia, Perth, Australia86School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia87School of Population Health, University of WA, Perth, Australia.
Ferreira MA Ferreira Manuel A MA QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Thompson PJ Thompson Philip J PJ The Lung Health Clinic and Institute for Respiratory Health, University of Western Australia, Perth, Australia.
Morrison AC Morrison Alanna C AC Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston.
Felix JF Felix Janine F JF Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Smith NL Smith Nicholas L NL Department of Epidemiology, University of Washington, Seattle.
Christiano AM Christiano Angela M AM Departments of Dermatology and Genetics & Development, Columbia University, New York, New York.
Petukhova L Petukhova Lynn L Departments of Dermatology and Epidemiology, Columbia University, New York, New York.
Betz RC Betz Regina C RC Institute of Human Genetics, University of Bonn, Bonn, Germany.
Fan X Fan Xing X Institute of Dermatology & Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Zhang X Zhang Xuejun X Institute of Dermatology & Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Zhu C Zhu Caihong C Institute of Dermatology & Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Langefeld CD Langefeld Carl D CD Center for Public Health Genomics, Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Thompson SD Thompson Susan D SD Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Wang F Wang Feijie F Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Lin X Lin Xu X Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Schwartz DA Schwartz David A DA Department of Medicine, School of Medicine, University of Colorado, Aurora.
Fingerlin T Fingerlin Tasha T Department of Biomedical Research, National Jewish Health Hospital, Denver, Colorado.
Rotter JI Rotter Jerome I JI Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California101Departments of Pediatrics and Medicine, Harbor-UCLA Medical Center, Torrance, California.
Cotch MF Cotch Mary Frances MF Epidemiology Branch, Division of Epidemiology and Clinical Applications, Intramural Research Program, National Eye Institute, National Institutes of Health, Clinical Research Center, Bethesda, Maryland.
Jensen RA Jensen Richard A RA Cardiovascular Health Research Unit, University of Washington, Seattle104Department of Medicine, University of Washington, Seattle.
Munz M Munz Matthias M Department of Periodontology and Synoptic Dentistry, Center for Dental and Craniofacial Sciences, Charité - University Medicine Berlin, Berlin, Germany106Institute for Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.
Dommisch H Dommisch Henrik H Department of Periodontology and Synoptic Dentistry, Center for Dental and Craniofacial Sciences, Charité - University Medicine Berlin, Berlin, Germany.
Schaefer AS Schaefer Arne S AS Department of Periodontology and Synoptic Dentistry, Center for Dental and Craniofacial Sciences, Charité - University Medicine Berlin, Berlin, Germany.
Han F Han Fang F Department of Pulmonary Medicine, Peking University People's Hospital, Beijing, China.
Ollila HM Ollila Hanna M HM Stanford University, Center for Sleep Sciences, Palo Alto, California.
Hillary RP Hillary Ryan P RP Stanford University, Center for Sleep Sciences, Palo Alto, California.
Albagha O Albagha Omar O Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Doha, Qatar110Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland.
Ralston SH Ralston Stuart H SH Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland.
Zeng C Zeng Chenjie C Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Zheng W Zheng Wei W Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Shu XO Shu Xiao-Ou XO Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Reis A Reis Andre A Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Uebe S Uebe Steffen S Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Hüffmeier U Hüffmeier Ulrike U Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Kawamura Y Kawamura Yoshiya Y Department of Psychiatry, Shonan Kamakura General Hospital, Kanagawa, Japan.
Otowa T Otowa Takeshi T Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan115Graduate School of Clinical Psychology, Teikyo Heisei University Major of Professional Clinical Psychology, Tokyo, Japan.
Sasaki T Sasaki Tsukasa T Department of Physical and Health Education, Graduate School of Education, University of Tokyo, Tokyo, Japan.
Hibberd ML Hibberd Martin Lloyd ML Infectious Diseases, Genome Institute of Singapore, Singapore.
Davila S Davila Sonia S Human Genetics, Genome Institute of Singapore, Singapore.
Xie G Xie Gang G Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada119Departments of Medicine, Immunology, Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Siminovitch K Siminovitch Katherine K Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada119Departments of Medicine, Immunology, Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Bei JX Bei Jin-Xin JX Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Zeng YX Zeng Yi-Xin YX Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China121Peking Union Medical College, Beijing, China.
Försti A Försti Asta A Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany123Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
Chen B Chen Bowang B Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Landi S Landi Stefano S Department of Biology, University of Pisa, Pisa, Italy.
Franke A Franke Andre A University Hospital Schleswig-Holstein, Kiel, Germany.
Fischer A Fischer Annegret A University Hospital Schleswig-Holstein, Kiel, Germany126Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Ellinghaus D Ellinghaus David D Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Flores C Flores Carlos C Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Tenerife, Spain128CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
Noth I Noth Imre I Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois.
Ma SF Ma Shwu-Fan SF Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois.
Foo JN Foo Jia Nee JN Human Genetics, Genome Institute of Singapore, A*STAR, Singapore.
Liu J Liu Jianjun J Human Genetics, Genome Institute of Singapore, A*STAR, Singapore.
Kim JW Kim Jong-Won JW Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan, University School of Medicine, Gangnam-gu, Seoul, South Korea.
Cox DG Cox David G DG Cancer Research Center of Lyon, INSERM U1052, Lyon, France.
Delattre O Delattre Olivier O Inserm U830, Institut Curie, PSL University, Paris, France.
Mirabeau O Mirabeau Olivier O Inserm U830, Institut Curie, PSL University, Paris, France.
Skibola CF Skibola Christine F CF Department of Epidemiology, University of Alabama at Birmingham.
Tang CS Tang Clara S CS Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Garcia-Barcelo M Garcia-Barcelo Merce M Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Chang KP Chang Kai-Ping KP Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital at Lin-Kou, Taoyuan, Taiwan.
Su WH Su Wen-Hui WH Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital at Lin-Kou, Taoyuan, Taiwan137Department of Biomedical Sciences, Graduate Institute of Biomedical Sciences, College of Medicine, Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.
Chang YS Chang Yu-Sun YS Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Gordon S Gordon Scott S QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Wade TD Wade Tracey D TD School of Psychology, Flinders University, Adelaide, South Australia.
Lee C Lee Chaeyoung C School of Systems Biomedical Science, Soongsil University, Dongjak-gu, Seoul, South Korea.
Kubo M Kubo Michiaki M RIKEN Center for Integrative Medical Science, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan.
Cha PC Cha Pei-Chieng PC Division of Molecular Brain Science, Kobe University Graduate School of Medicine, Kusunoki-chou, Chuo-ku, Kobe, Japan.
Nakamura Y Nakamura Yusuke Y Center for Personalized Therapeutics, The University of Chicago, Chicago, Illinois.
Levy D Levy Daniel D The NHLBI's Framingham Heart Study, Framingham, Massachusetts, Population Sciences Branch of the National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Kimura M Kimura Masayuki M Center of Human Development and Aging, Department of Pediatrics, New Jersey Medical School, Rutgers, The State University of New Jersey.
Hwang SJ Hwang Shih-Jen SJ The NHLBI's Framingham Heart Study, Framingham, Massachusetts, Population Sciences Branch of the National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Hunt S Hunt Steven S Department of Genetic Medicine, Weill Cornell Medicine in Qatar, Doha, Qatar.
Spector T Spector Tim T Department of Twin Research and Genetic Epidemiology, King's College London, London England.
Soranzo N Soranzo Nicole N Human Genetics, Wellcome Trust Sanger Institute, Genome Campus, Hinxton Cambridge, England.
Manichaikul AW Manichaikul Ani W AW Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville.
Barr RG Barr R Graham RG Department of Medicine and Department of Epidemiology, Columbia University Medical Center, New York, New York.
Kahali B Kahali Bratati B Department of Internal Medicine, Division of Gastroenterology and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor.
Speliotes E Speliotes Elizabeth E Department of Internal Medicine, Division of Gastroenterology and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor.
Yerges-Armstrong LM Yerges-Armstrong Laura M LM Department of Medicine, University of Maryland, Baltimore.
Cheng CY Cheng Ching-Yu CY Singapore Eye Research Institute, Singapore National Eye Center, Singapore152Department of Ophthalmology, National University of Singapore and National University Health System, Singapore153Duke-NUS Medical School, Singapore.
Jonas JB Jonas Jost B JB Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China155Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Mannheim, Germany.
Wong TY Wong Tien Yin TY Singapore Eye Research Institute, Singapore National Eye Center, Singapore152Department of Ophthalmology, National University of Singapore and National University Health System, Singapore153Duke-NUS Medical School, Singapore.
Fogh I Fogh Isabella I Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.
Lin K Lin Kuang K Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.
Powell JF Powell John F JF Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.
Rice K Rice Kenneth K Department of Biostatistics, University of Washington, Seattle.
Relton CL Relton Caroline L CL MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Martin RM Martin Richard M RM MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England158University of Bristol/University Hospitals Bristol NHS Foundation Trust National Institute for Health Research Bristol Nutrition Biomedical Research Unit, Bristol, England.
Davey Smith G Davey Smith George G MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: JAMA oncology
ISOABBREVIATION: JAMA Oncol
YEAR: 2017
MONTH: Feb
DAY: 23
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2374-2445
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: JAMA Oncol
COUNTRY: United States
ISSNLINKING: 2374-2437
NLMUNIQUEID: 101652861
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's