Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
27797688
TITLE
Cannabis Involvement and Nonsuicidal Self-Injury: A Discordant Twin Approach.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
Cannabis use, particularly at an early age, has been linked to suicidal thoughts and behavior, but minimal work has examined the association between cannabis use and lifetime nonsuicidal self-injury (NSSI). The current study aims to characterize the overlap between lifetime and early cannabis use and NSSI and to examine genetic and environmental mechanisms of this association.
METHOD NlmCategory: METHODS
Adult male and female twins from the Australian Twin Registry (N = 9,583) were used to examine the odds of NSSI associated with lifetime cannabis use and early cannabis use (i.e., <17 years of age). These associations were also examined within monozygotic (MZ) twins discordant for cannabis use and MZ twins discordant for early cannabis use. Analyses were replicated in an independent sample of female twins (n = 3,787) accounting for the age at onset of cannabis use and NSSI.
RESULTS NlmCategory: RESULTS
Lifetime cannabis use (odds ratio [OR] = 2.84, 95% CI [2.23, 3.61]) and early cannabis use were associated with increased odds of NSSI (OR = 2.15, 95% CI [1.75, 2.65]), and this association remained when accounting for covariates. The association was only significant, however, in MZ twin pairs discordant for early cannabis use (OR = 3.20, 95% CI [1.17, 8.73]). Replication analyses accounting for the temporal ordering of cannabis use and NSSI yielded similar findings of nominal significance.
CONCLUSIONS NlmCategory: CONCLUSIONS
Results suggest that NSSI is associated with cannabis involvement via differing mechanisms. For lifetime cannabis use, the lack of association in discordant pairs suggests the role of shared genes and family environment. However, in addition to such shared familial influences, person-specific and putatively causal factors contribute to the relationship between early cannabis use and NSSI. Therefore, delaying the onset of cannabis use may reduce exposure to influences that exacerbate vulnerabilities to NSSI.
DATE PUBLISHED
2016 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2016/11/01 06:00
medline 2016/11/01 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Few LR Few Lauren R LR Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Grant JD Grant Julia D JD Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Nelson EC Nelson Elliot C EC Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Trull TJ Trull Timothy J TJ Department of Psychological Sciences, University of Missouri, Columbia, Missouri.
Grucza RA Grucza Richard A RA Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Bucholz KK Bucholz Kathleen K KK Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Verweij KJ Verweij Karin J H KJ Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Statham DJ Statham Dixie J DJ School of Social Sciences, University of the Sunshine Coast, Sippy Downs, Queensland, Australia.
Madden PA Madden Pamela A F PA Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Heath AC Heath Andrew C AC Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Lynskey MT Lynskey Michael T MT Addictions Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Agrawal A Agrawal Arpana A Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
INVESTIGATORS
JOURNAL
VOLUME: 77
ISSUE: 6
TITLE: Journal of studies on alcohol and drugs
ISOABBREVIATION: J Stud Alcohol Drugs
YEAR: 2016
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1938-4114
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Stud Alcohol Drugs
COUNTRY: United States
ISSNLINKING: 1937-1888
NLMUNIQUEID: 101295847
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
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