Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
27590903
TITLE
The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries.
ABSTRACT
NlmCategory: UNASSIGNED
Non-suicidal and suicidal self-injury are very destructive, yet surprisingly common behaviours. Depressed mood is a major risk factor for non-suicidal self-injury (NSSI), suicidal ideation and suicide attempts. We conducted a genetic risk prediction study to examine the polygenic overlap of depressive symptoms with lifetime NSSI, suicidal ideation, and suicide attempts in a sample of 6237 Australian adult twins and their family members (3740 females, mean age = 42.4 years). Polygenic risk scores for depressive symptoms significantly predicted suicidal ideation, and some predictive ability was found for suicide attempts; the polygenic risk scores explained a significant amount of variance in suicidal ideation (lowest p = 0.008, explained variance ranging from 0.10 to 0.16 %) and, less consistently, in suicide attempts (lowest p = 0.04, explained variance ranging from 0.12 to 0.23 %). Polygenic risk scores did not significantly predict NSSI. Results highlight that individuals genetically predisposed to depression are also more likely to experience suicidal ideation/behaviour, whereas we found no evidence that this is also the case for NSSI.
DATE PUBLISHED
2016 Sep 2
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/02/10
accepted 2016/08/23
aheadofprint 2016/09/02
entrez 2016/09/04 06:00
pubmed 2016/09/04 06:00
medline 2016/09/04 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Maciejewski DF Maciejewski Dominique F DF Department of Clinical Developmental Psychology and EMGO Institute for Health and Care Research, Vrije Universiteit Amsterdam, 1081 BT, Amsterdam, The Netherlands.
Renteria ME Renteria Miguel E ME Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Abdellaoui A Abdellaoui Abdel A Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Medland SE Medland Sarah E SE Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Few LR Few Lauren R LR Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA.
Gordon SD Gordon Scott D SD Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Madden PA Madden Pamela A F PA Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA.
Montgomery G Montgomery Grant G Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Trull TJ Trull Timothy J TJ Department of Psychological Sciences, University of Missouri, Columbia, MO, 65211, USA.
Heath AC Heath Andrew C AC Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA.
Statham DJ Statham Dixie J DJ Faculty of Arts and Social Sciences, University of Sunshine Coast, Sippy Downs, QLD, 4556, Australia.
Martin NG Martin Nicholas G NG Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Zietsch BP Zietsch Brendan P BP School of Psychology, University of Queensland, St. Lucia, Brisbane, QLD, 4029, Australia.
Verweij KJ Verweij Karin J H KJ School of Psychology, University of Queensland, St. Lucia, Brisbane, QLD, 4029, Australia. karin.verweij@vu.nl.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2016
MONTH: Sep
DAY: 2
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1573-3297
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Depression
Genetics
Polygenic risk
Self-injury
Suicidal ideation
Suicide attempts
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's