Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
27546527
TITLE
Personality Polygenes, Positive Affect, and Life Satisfaction.
ABSTRACT
NlmCategory: UNASSIGNED
Approximately half of the variation in wellbeing measures overlaps with variation in personality traits. Studies of non-human primate pedigrees and human twins suggest that this is due to common genetic influences. We tested whether personality polygenic scores for the NEO Five-Factor Inventory (NEO-FFI) domains and for item response theory (IRT) derived extraversion and neuroticism scores predict variance in wellbeing measures. Polygenic scores were based on published genome-wide association (GWA) results in over 17,000 individuals for the NEO-FFI and in over 63,000 for the IRT extraversion and neuroticism traits. The NEO-FFI polygenic scores were used to predict life satisfaction in 7 cohorts, positive affect in 12 cohorts, and general wellbeing in 1 cohort (maximal N = 46,508). Meta-analysis of these results showed no significant association between NEO-FFI personality polygenic scores and the wellbeing measures. IRT extraversion and neuroticism polygenic scores were used to predict life satisfaction and positive affect in almost 37,000 individuals from UK Biobank. Significant positive associations (effect sizes <0.05%) were observed between the extraversion polygenic score and wellbeing measures, and a negative association was observed between the polygenic neuroticism score and life satisfaction. Furthermore, using GWA data, genetic correlations of -0.49 and -0.55 were estimated between neuroticism with life satisfaction and positive affect, respectively. The moderate genetic correlation between neuroticism and wellbeing is in line with twin research showing that genetic influences on wellbeing are also shared with other independent personality domains.
DATE PUBLISHED
2016 Aug 22
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2016/08/23 06:00
pubmed 2016/08/23 06:00
medline 2016/08/23 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Weiss A Weiss Alexander A Centre for Cognitive Ageing and Cognitive Epidemiology,Department of Psychology,School of Philosophy,Psychology and Language Sciences,The University of Edinburgh,Edinburgh,UK.
Baselmans BM Baselmans Bart M L BM Department of Biological Psychology,Netherlands Twin Register,VU University Amsterdam,Amsterdam,the Netherlands.
Hofer E Hofer Edith E Clinical Division of Neurogeriatrics,Department of Neurology,Medical University Graz,Austria.
Yang J Yang Jingyun J Rush Alzheimer's Disease Center,Rush University Medical Center,Chicago,IL,USA.
Okbay A Okbay Aysu A Department of Applied Economics,Erasmus School of Economics,Erasmus University Rotterdam,Rotterdam,the Netherlands.
Lind PA Lind Penelope A PA Quantitative Genetics,QIMR Berghofer Institute of Medical Research,Brisbane,Queensland,Australia.
Miller MB Miller Mike B MB Department of Psychology,University of Minnesota,USA.
Nolte IM Nolte Ilja M IM Department of Epidemiology,University of Groningen,Groningen,the Netherlands.
Zhao W Zhao Wei W Survey Research Center,Institute for Social Research,University of Michigan,Ann Arbor,MI,USA.
Hagenaars SP Hagenaars Saskia P SP Centre for Cognitive Ageing and Cognitive Epidemiology,Department of Psychology,School of Philosophy,Psychology and Language Sciences,The University of Edinburgh,Edinburgh,UK.
Hottenga JJ Hottenga Jouke-Jan JJ Department of Biological Psychology,Netherlands Twin Register,VU University Amsterdam,Amsterdam,the Netherlands.
Matteson LK Matteson Lindsay K LK Department of Psychology,University of Minnesota,USA.
Snieder H Snieder Harold H Department of Epidemiology,University of Groningen,Groningen,the Netherlands.
Faul JD Faul Jessica D JD Department of Epidemiology,School of Public Health,University of Michigan,Ann Arbor,MI,USA.
Hartman CA Hartman Catharina A CA Interdisciplinary Center Psychopathology and Emotion regulation,University Medical Center,University of Groningen,Groningen,the Netherlands.
Boyle PA Boyle Patricia A PA Rush Alzheimer's Disease Center,Rush University Medical Center,Chicago,IL,USA.
Tiemeier H Tiemeier Henning H Department of Epidemiology,Erasmus Medical Center,Rotterdam,the Netherlands.
Mosing MA Mosing Miriam A MA Department of Neuroscience,Karolinska Institutet,Stockholm,Sweden.
Pattie A Pattie Alison A Centre for Cognitive Ageing and Cognitive Epidemiology,Department of Psychology,School of Philosophy,Psychology and Language Sciences,The University of Edinburgh,Edinburgh,UK.
Davies G Davies Gail G Centre for Cognitive Ageing and Cognitive Epidemiology,Department of Psychology,School of Philosophy,Psychology and Language Sciences,The University of Edinburgh,Edinburgh,UK.
Liewald DC Liewald David C DC Centre for Cognitive Ageing and Cognitive Epidemiology,Department of Psychology,School of Philosophy,Psychology and Language Sciences,The University of Edinburgh,Edinburgh,UK.
Schmidt R Schmidt Reinhold R Clinical Division of Neurogeriatrics,Department of Neurology,Medical University Graz,Austria.
De Jager PL De Jager Philip L PL Program in Translational NeuroPsychiatric Genomics,Institute for the Neurosciences,Departments of Neurology and Psychiatry,Brigham and Women's Hospital,Boston,MA,USA.
Heath AC Heath Andrew C AC Division of Biology and Biomedical Sciences,Washington University,MO,USA.
Jokela M Jokela Markus M Institute of Behavioural Sciences,University of Helsinki,Finland.
Starr JM Starr John M JM Geriatric Medicine Unit,Western General Hospital,Edinburgh,and Centre for Cognitive Ageing and Cognitive Epidemiology,University of Edinburgh,UK.
Oldehinkel AJ Oldehinkel Albertine J AJ Interdisciplinary Center Psychopathology and Emotion regulation,University Medical Center,University of Groningen,Groningen,the Netherlands.
Johannesson M Johannesson Magnus M Department of Economics,Stockholm School of Economics,Stockholm,Sweden.
Cesarini D Cesarini David D Department of Economics,New York University,New York,USA.
Hofman A Hofman Albert A Department of Epidemiology,Erasmus Medical Center,Rotterdam,the Netherlands.
Harris SE Harris Sarah E SE Centre for Cognitive Ageing and Cognitive Epidemiology,Department of Psychology,School of Philosophy,Psychology and Language Sciences,The University of Edinburgh,Edinburgh,UK.
Smith JA Smith Jennifer A JA Survey Research Center,Institute for Social Research,University of Michigan,Ann Arbor,MI,USA.
Keltikangas-Järvinen L Keltikangas-Järvinen Liisa L IBS,Unit of Personality,Work and Health,Institute of Behavioural Sciences,University of Helsinki,Finland.
Pulkki-Råback L Pulkki-Råback Laura L IBS,Unit of Personality,Work and Health,Institute of Behavioural Sciences,University of Helsinki,Finland.
Schmidt H Schmidt Helena H Department of Neurology,Medical University Graz,Austria.
Smith J Smith Jacqui J Department of Psychology,University of Michigan,Ann Arbor,MI,USA.
Iacono WG Iacono William G WG Department of Psychology,University of Minnesota,USA.
McGue M McGue Matt M Department of Psychology,University of Minnesota,USA.
Bennett DA Bennett David A DA Rush Alzheimer's Disease Center,Rush University Medical Center,Chicago,IL,USA.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics,Karolinska Institutet,Stockholm,Sweden.
Magnusson PK Magnusson Patrik K E PK Department of Medical Epidemiology and Biostatistics,Karolinska Institutet,Stockholm,Sweden.
Deary IJ Deary Ian J IJ Centre for Cognitive Ageing and Cognitive Epidemiology,Department of Psychology,School of Philosophy,Psychology and Language Sciences,The University of Edinburgh,Edinburgh,UK.
Martin NG Martin Nicholas G NG Quantitative Genetics,QIMR Berghofer Institute of Medical Research,Brisbane,Queensland,Australia.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology,Netherlands Twin Register,VU University Amsterdam,Amsterdam,the Netherlands.
Bartels M Bartels Meike M Department of Biological Psychology,Netherlands Twin Register,VU University Amsterdam,Amsterdam,the Netherlands.
Luciano M Luciano Michelle M Centre for Cognitive Ageing and Cognitive Epidemiology,Department of Psychology,School of Philosophy,Psychology and Language Sciences,The University of Edinburgh,Edinburgh,UK.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2016
MONTH: Aug
DAY: 22
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1832-4274
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
genetic correlation
genetics
happiness
polygenic prediction
wellbeing
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's