Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
27460396
TITLE
Most of the genetic covariation between major depressive and alcohol use disorders is explained by trait measures of negative emotionality and behavioral control.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Mental health disorders commonly co-occur, even between conceptually distinct syndromes, such as internalizing and externalizing disorders. The current study investigated whether phenotypic, genetic, and environmental variance in negative emotionality and behavioral control account for the covariation between major depressive disorder (MDD) and alcohol use disorder (AUD).
METHOD NlmCategory: METHODS
A total of 3623 members of a national twin registry were administered structured diagnostic telephone interviews that included assessments of lifetime histories of MDD and AUD, and were mailed self-report personality questionnaires that assessed stress reactivity (SR) and behavioral control (CON). A series of biometric models were fitted to partition the proportion of covariance between MDD and AUD into SR and CON.
RESULTS NlmCategory: RESULTS
A statistically significant proportion of the correlation between MDD and AUD was due to variance specific to SR (men = 0.31, women = 0.27) and CON (men = 0.20, women = 0.19). Further, genetic factors explained a large proportion of this correlation (0.63), with unique environmental factors explaining the rest. SR explained a significant proportion of the genetic (0.33) and environmental (0.23) overlap between MDD and AUD. In contrast, variance specific to CON accounted for genetic overlap (0.32), but not environmental overlap (0.004). In total, SR and CON accounted for approximately 70% of the genetic and 20% of the environmental covariation between MDD and AUD.
CONCLUSIONS NlmCategory: CONCLUSIONS
This is the first study to demonstrate that negative emotionality and behavioral control confer risk for the co-occurrence of MDD and AUD via genetic factors. These findings are consistent with the aims of NIMH's RDoC proposal to elucidate how transdiagnostic risk factors drive psychopathology.
DATE PUBLISHED
2016 Jul 27
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2016/07/28 06:00
pubmed 2016/07/28 06:00
medline 2016/07/28 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Ellingson JM Ellingson J M JM Department of Psychological Sciences,University of Missouri,Columbia, MO,USA.
Richmond-Rakerd LS Richmond-Rakerd L S LS Department of Psychological Sciences,University of Missouri,Columbia, MO,USA.
Statham DJ Statham D J DJ University of the Sunshine Coast,Queensland,Australia.
Martin NG Martin N G NG Genetic Epidemiology Laboratory,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Slutske WS Slutske W S WS Department of Psychological Sciences,University of Missouri,Columbia, MO,USA.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Psychological medicine
ISOABBREVIATION: Psychol Med
YEAR: 2016
MONTH: Jul
DAY: 27
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1469-8978
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Psychol Med
COUNTRY: England
ISSNLINKING: 0033-2917
NLMUNIQUEID: 1254142
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Alcohol use disorder
behavior genetics
behavioral control
co-morbidity
dual diagnosis
externalizing
internalizing
major depressive disorder
negative emotionality
research domain criteria
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's