Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
27417028
TITLE
From alcohol initiation to tolerance to problems: Discordant twin modeling of a developmental process.
ABSTRACT
NlmCategory: UNASSIGNED
The current study examined a stage-based alcohol use trajectory model to test for potential causal effects of earlier drinking milestones on later drinking milestones in a combined sample of two cohorts of Australian monozygotic and same-sex dizygotic twins (N = 7,398, age M = 30.46, SD = 2.61, 61% male, 56% monozygotic twins). Ages of drinking, drunkenness, regular drinking, tolerance, first nontolerance alcohol use disorder symptom, and alcohol use disorder symptom onsets were assessed retrospectively. Ages of milestone attainment (i.e., age-of-onset) and time between milestones (i.e., time-to-event) were examined via frailty models within a multilevel discordant twin design. For age-of-onset models, earlier ages of onset of antecedent drinking milestones increased hazards for earlier ages of onset for more proximal subsequent drinking milestones. For the time-to-event models, however, earlier ages of onset for the "starting" milestone decreased risk for a shorter time period between the starting and the "ending" milestone. Earlier age of onset of intermediate milestones between starting and ending drinking milestones had the opposite effect, increasing risk for a shorter time period between the starting and ending milestones. These results are consistent with a causal effect of an earlier age of drinking milestone onset on temporally proximal subsequent drinking milestones.
DATE PUBLISHED
2016 Jul 15
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2016/07/16 06:00
pubmed 2016/07/16 06:00
medline 2016/07/16 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Deutsch AR Deutsch Arielle R AR University of Missouri-Columbia.
Slutske WS Slutske Wendy S WS University of Missouri-Columbia.
Lynskey MT Lynskey Michael T MT Washington University School of Medicine.
Bucholz KK Bucholz Kathleen K KK Washington University School of Medicine.
Madden PA Madden Pamela A F PA Washington University School of Medicine.
Heath AC Heath Andrew C AC Washington University School of Medicine.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Development and psychopathology
ISOABBREVIATION: Dev. Psychopathol.
YEAR: 2016
MONTH: Jul
DAY: 15
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1469-2198
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Dev Psychopathol
COUNTRY:
ISSNLINKING: 0954-5794
NLMUNIQUEID: 8910645
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
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