Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
27333805
TITLE
Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts.
ABSTRACT
Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.
DATE PUBLISHED
2016
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/03/07
accepted 2016/06/02
entrez 2016/06/24 06:00
pubmed 2016/06/24 06:00
medline 2016/06/24 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Jelenkovic A Jelenkovic Aline A Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Sund R Sund Reijo R Department of Social Research, University of Helsinki, Helsinki, Finland.
Hur YM Hur Yoon-Mi YM Department of Education, Mokpo National University, Jeonnam, South Korea.
Yokoyama Y Yokoyama Yoshie Y Department of Public Health Nursing, Osaka City University, Osaka, Japan.
Hjelmborg JV Hjelmborg Jacob V B JV The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics &Biodemography, University of Southern Denmark, Odense, Denmark.
Möller S Möller Sören S The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics &Biodemography, University of Southern Denmark, Odense, Denmark.
Honda C Honda Chika C Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Magnusson PK Magnusson Patrik K E PK Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Ooki S Ooki Syuichi S Department of Health Science, Ishikawa Prefectural Nursing University, Kahoku, Ishikawa, Japan.
Aaltonen S Aaltonen Sari S Department of Public Health, University of Helsinki, Helsinki, Finland.
Stazi MA Stazi Maria A MA Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
Fagnani C Fagnani Corrado C Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
D'Ippolito C D'Ippolito Cristina C Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy.
Freitas DL Freitas Duarte L DL Department of Physical Education and Sport, University of Madeira, Funchal, Portugal.
Maia JA Maia José Antonio JA CIFI2D, Faculty of Sport, Porto, University of Porto, Portugal.
Ji F Ji Fuling F Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Ning F Ning Feng F Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Pang Z Pang Zengchang Z Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Rebato E Rebato Esther E Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Busjahn A Busjahn Andreas A HealthTwiSt GmbH, Berlin, Germany.
Kandler C Kandler Christian C Department of Psychology, Bielefeld University, Bielefeld, Germany.
Saudino KJ Saudino Kimberly J KJ Boston University, Department of Psychological and Brain Sciencies, Boston, MA, USA.
Jang KL Jang Kerry L KL Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
Cozen W Cozen Wendy W USC Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Hwang AE Hwang Amie E AE Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Mack TM Mack Thomas M TM USC Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Gao W Gao Wenjing W Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Yu C Yu Canqing C Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Li L Li Liming L Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Corley RP Corley Robin P RP Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA.
Huibregtse BM Huibregtse Brooke M BM Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA.
Derom CA Derom Catherine A CA Department of Obstetrics and Gynaecology, Ghent University Hospitals, Ghent, Belgium.
Vlietinck RF Vlietinck Robert F RF Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Loos RJ Loos Ruth J F RJ The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Heikkilä K Heikkilä Kauko K Department of Public Health, University of Helsinki, Helsinki, Finland.
Wardle J Wardle Jane J Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Llewellyn CH Llewellyn Clare H CH Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Fisher A Fisher Abigail A Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK.
McAdams TA McAdams Tom A TA King's College London, MRC Social, Genetic &Developmental Psychiatry Centre, Institute of Psychiatry, Psychology &Neuroscience, London, UK.
Eley TC Eley Thalia C TC King's College London, MRC Social, Genetic &Developmental Psychiatry Centre, Institute of Psychiatry, Psychology &Neuroscience, London, UK.
Gregory AM Gregory Alice M AM Department of Psychology, Goldsmiths, University of London, London, UK.
He M He Mingguang M Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia.
Ding X Ding Xiaohu X State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Bjerregaard-Andersen M Bjerregaard-Andersen Morten M Department of Endocrinology, Odense University Hospital, Odense, Denmark.
Beck-Nielsen H Beck-Nielsen Henning H Department of Endocrinology, Odense University Hospital, Odense, Denmark.
Sodemann M Sodemann Morten M Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.
Tarnoki AD Tarnoki Adam D AD Hungarian Twin Registry, Budapest, Hungary.
Tarnoki DL Tarnoki David L DL Hungarian Twin Registry, Budapest, Hungary.
Knafo-Noam A Knafo-Noam Ariel A The Hebrew University of Jerusalem, Jerusalem, Israel.
Mankuta D Mankuta David D Hadassah Hospital Obstetrics and Gynecology Department, Hebrew University Medical School, Jerusalem, Israel.
Abramson L Abramson Lior L The Hebrew University of Jerusalem, Jerusalem, Israel.
Burt SA Burt S Alexandra SA Michigan State University, East Lansing, Michigan, USA.
Klump KL Klump Kelly L KL Michigan State University, East Lansing, Michigan, USA.
Silberg JL Silberg Judy L JL Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
Eaves LJ Eaves Lindon J LJ Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
Maes HH Maes Hermine H HH Department of Human and Molecular Genetics, Psychiatry &Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Krueger RF Krueger Robert F RF Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
McGue M McGue Matt M Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Pahlen S Pahlen Shandell S Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Gatz M Gatz Margaret M Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Butler DA Butler David A DA Institute of Medicine, National Academy of Sciences, Washington, DC, USA.
Bartels M Bartels Meike M Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
van Beijsterveldt TC van Beijsterveldt Toos C E M TC Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Craig JM Craig Jeffrey M JM Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.
Saffery R Saffery Richard R Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.
Dubois L Dubois Lise L School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Boivin M Boivin Michel M Institute of Genetic, Neurobiological, and Social Foundations of Child Development, Tomsk State University, Russian Federation.
Brendgen M Brendgen Mara M Département de psychologie, Université du Québec à Montréal, Montréal, Québec, Canada.
Dionne G Dionne Ginette G École de psychologie, Université Laval, Québec, Canada.
Vitaro F Vitaro Frank F École de psychoéducation, Université de Montréal, Montréal, Québec, Canada.
Martin NG Martin Nicholas G NG Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Medland SE Medland Sarah E SE Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Montgomery GW Montgomery Grant W GW Molecular Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Swan GE Swan Gary E GE Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Krasnow R Krasnow Ruth R Center for Health Sciences, SRI International, Menlo Park, CA, USA.
Tynelius P Tynelius Per P Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Lichtenstein P Lichtenstein Paul P Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Haworth CM Haworth Claire M A CM MRC Integrative Epidemiology Unit, University of Bristol, Bristol, U.K.
Plomin R Plomin Robert R King's College London, MRC Social, Genetic &Developmental Psychiatry Centre, Institute of Psychiatry, Psychology &Neuroscience, London, UK.
Bayasgalan G Bayasgalan Gombojav G Healthy Twin Association of Mongolia, Ulaanbaatar, Mongolia.
Narandalai D Narandalai Danshiitsoodol D Healthy Twin Association of Mongolia, Ulaanbaatar, Mongolia.
Harden KP Harden K Paige KP Department of Psychology, University of Texas at Austin, Austin, TX, USA.
Tucker-Drob EM Tucker-Drob Elliot M EM Department of Psychology, University of Texas at Austin, Austin, TX, USA.
Spector T Spector Timothy T Department of Twin Research and Genetic Epidemiology, King's College, London, UK.
Mangino M Mangino Massimo M Department of Twin Research and Genetic Epidemiology, King's College, London, UK.
Lachance G Lachance Genevieve G Department of Twin Research and Genetic Epidemiology, King's College, London, UK.
Baker LA Baker Laura A LA Department of Psychology, University of Southern California, Los Angeles, CA, USA.
Tuvblad C Tuvblad Catherine C School of Law, Psychology and Social Work, Örebro University, Sweden.
Duncan GE Duncan Glen E GE Washington State Twin Registry, Washington State University - Health Sciences Spokane, Spokane, WA, USA.
Buchwald D Buchwald Dedra D Washington State Twin Registry, Washington State University, Seattle, WA, USA.
Willemsen G Willemsen Gonneke G Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Skytthe A Skytthe Axel A The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics &Biodemography, University of Southern Denmark, Odense, Denmark.
Kyvik KO Kyvik Kirsten O KO Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark.
Christensen K Christensen Kaare K Department of Clinical Biochemistry and Pharmacology and Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Öncel SY Öncel Sevgi Y SY Department of Statistics, Faculty of Arts and Sciences, Kırıkkale University, Kırıkkale, Turkey.
Aliev F Aliev Fazil F Departments of Psychiatry, Psychology, and Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA.
Rasmussen F Rasmussen Finn F Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Goldberg JH Goldberg Jack H JH Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Sørensen TI Sørensen Thorkild I A TI Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands.
Kaprio J Kaprio Jaakko J Institute for Molecular Medicine FIMM, Helsinki, Finland.
Silventoinen K Silventoinen Karri K Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
INVESTIGATORS
JOURNAL
VOLUME: 6
ISSUE:
TITLE: Scientific reports
ISOABBREVIATION: Sci Rep
YEAR: 2016
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2045-2322
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Sci Rep
COUNTRY: England
ISSNLINKING: 2045-2322
NLMUNIQUEID: 101563288
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
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GENERAL NOTE
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OTHER ID's
OTHERID SOURCE
PMC4917845 NLM