Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
27315593
TITLE
Genome-wide association study of pathological gambling.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Pathological gambling is a behavioural addiction with negative economic, social, and psychological consequences. Identification of contributing genes and pathways may improve understanding of aetiology and facilitate therapy and prevention. Here, we report the first genome-wide association study of pathological gambling. Our aims were to identify pathways involved in pathological gambling, and examine whether there is a genetic overlap between pathological gambling and alcohol dependence.
METHODS NlmCategory: METHODS
Four hundred and forty-five individuals with a diagnosis of pathological gambling according to the Diagnostic and Statistical Manual of Mental Disorders were recruited in Germany, and 986 controls were drawn from a German general population sample. A genome-wide association study of pathological gambling comprising single marker, gene-based, and pathway analyses, was performed. Polygenic risk scores were generated using data from a German genome-wide association study of alcohol dependence.
RESULTS NlmCategory: RESULTS
No genome-wide significant association with pathological gambling was found for single markers or genes. Pathways for Huntington's disease (P-value=6.63×10(-3)); 5'-adenosine monophosphate-activated protein kinase signalling (P-value=9.57×10(-3)); and apoptosis (P-value=1.75×10(-2)) were significant. Polygenic risk score analysis of the alcohol dependence dataset yielded a one-sided nominal significant P-value in subjects with pathological gambling, irrespective of comorbid alcohol dependence status.
CONCLUSIONS NlmCategory: CONCLUSIONS
The present results accord with previous quantitative formal genetic studies which showed genetic overlap between non-substance- and substance-related addictions. Furthermore, pathway analysis suggests shared pathology between Huntington's disease and pathological gambling. This finding is consistent with previous imaging studies.
Copyright (c) 2016 Elsevier Masson SAS. All rights reserved.
DATE PUBLISHED
2016 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/11/06
revised 2016/03/09
accepted 2016/04/01
entrez 2016/06/18 06:00
pubmed 2016/06/18 06:00
medline 2016/06/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Lang M
Lemenager T
Streit F
Fauth-Buhler M
Frank J
Juraeva D
Witt SH
Degenhardt F
Hofmann A
Heilmann-Heimbach S
Kiefer F
Brors B
Grabe HJ
John U
Bischof A
Bischof G
Volker U
Homuth G
Beutel M
Lind PA
Medland SE
Slutske WS
Martin NG
Volzke H
Nothen MM
Meyer C
Rumpf HJ
Wurst FM
Rietschel M
Mann KF
INVESTIGATORS
JOURNAL
VOLUME: 36
ISSUE:
TITLE: European psychiatry : the journal of the Association of European Psychiatrists
ISOABBREVIATION: Eur. Psychiatry
YEAR: 2016
MONTH: Jun
DAY: 14
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1778-3585
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Eur Psychiatry
COUNTRY:
ISSNLINKING: 0924-9338
NLMUNIQUEID: 9111820
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Addiction
Association
Gambling
Genetics
Genome-wide
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's