Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26871925
TITLE
Heritability of naevus patterns in an adult twin cohort from the Brisbane Twin Registry: a cross-sectional study.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Heritability of naevi counts is widely acknowledged as a potential surveillance parameter for prevention purposes. The contribution of heritability to the changes seen in naevus number and morphology over time and their corresponding dermoscopic characteristics is unknown, but is important to understand in order to account for adequate prevention measures.
OBJECTIVES NlmCategory: OBJECTIVE
To identify naevus characteristics that are strongly influenced by heritability.
METHODS NlmCategory: METHODS
This cross-sectional study included 220 individuals [76 monozygotic (MZ), 144 dizygotic (DZ)], recruited from the Brisbane Twin Naevus Study. Participants received full body imaging and dermoscopy of naevi ≥ 5 mm in diameter. Dermoscopic type, total naevus count (TNC), change in TNC with age, and naevus distribution, size, colour and profile were compared between MZ and DZ twins. Heritability of these traits was assessed via Falconer's estimate.
RESULTS NlmCategory: RESULTS
Significant differences were found in comparing MZ and DZ twins for TNC, numbers of naevi 5·0-7·9 mm in diameter, counts of light-brown naevi, naevi on the back and sun-protected sites, and naevi with the 'nonspecific' dermoscopic pattern.
CONCLUSIONS NlmCategory: CONCLUSIONS
This study strongly supports a heritable component to TNC, as well as changes in TNC, and the number of medium-sized naevi, light-brown naevi, specific sites and certain dermoscopic features in adults. These characteristics should be taken into account by naevus surveillance programmes and further studied to identify candidate gene associations for clinical and dermoscopic patterns in conjunction with melanoma risk stratification.
(c) 2015 British Association of Dermatologists.
DATE PUBLISHED
2016 Feb
HISTORY
PUBSTATUS PUBSTATUSDATE
accepted 2015/11/02
aheadofprint 2016/01/22
entrez 2016/02/13 06:00
pubmed 2016/02/13 06:00
medline 2016/02/13 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Lee S
Duffy DL
McClenahan P
Lee KJ
McEniery E
Burke B
Jagirdar K
Martin NG
Sturm RA
Soyer HP
Schaider H
INVESTIGATORS
JOURNAL
VOLUME: 174
ISSUE: 2
TITLE: The British journal of dermatology
ISOABBREVIATION: Br. J. Dermatol.
YEAR: 2016
MONTH: Feb
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1365-2133
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Br J Dermatol
COUNTRY: England
ISSNLINKING: 0007-0963
NLMUNIQUEID: 0004041
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
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