Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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26854805
TITLE
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.
ABSTRACT
NlmCategory: UNASSIGNED
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.
DATE PUBLISHED
2016 Feb 1
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/08/10
accepted 2015/12/22
entrez 2016/02/09 06:00
pubmed 2016/02/09 06:00
medline 2016/02/09 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Franke B Franke Barbara B Donders Institute for Brain, Cognition and Behaviour, Raboud University, Nijmegen, the Netherlands.
Stein JL Stein Jason L JL Neurogenetics Program, Department of Neurology, UCLA School of Medicine, Los Angeles, California, USA.
Ripke S Ripke Stephan S Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Anttila V Anttila Verneri V Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Hibar DP Hibar Derrek P DP Imaging Genetics Center, Mark and Mary Stevens Neuroimaging &Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA.
van Hulzen KJ van Hulzen Kimm J E KJ Donders Institute for Brain, Cognition and Behaviour, Raboud University, Nijmegen, the Netherlands.
Arias-Vasquez A Arias-Vasquez Alejandro A Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.
Smoller JW Smoller Jordan W JW Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Nichols TE Nichols Thomas E TE Department of Statistics &Warwick Manufacturing Group, University of Warwick, Coventry, UK.
Neale MC Neale Michael C MC Departments of Psychiatry &Human Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
McIntosh AM McIntosh Andrew M AM Division of Psychiatry, Royal Edinburgh Hospital, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Lee P Lee Phil P Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
McMahon FJ McMahon Francis J FJ Intramural Research Program, National Institutes of Health, US Department of Health &Human Services, Bethesda, Maryland, USA.
Meyer-Lindenberg A Meyer-Lindenberg Andreas A Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.
Mattheisen M Mattheisen Manuel M Center for integrated Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.
Andreassen OA Andreassen Ole A OA Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Gruber O Gruber Oliver O Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Goettingen, Germany.
Sachdev PS Sachdev Perminder S PS Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, New South Wales, Australia.
Roiz-Santiañez R Roiz-Santiañez Roberto R Cibersam (Centro Investigación Biomédica en Red Salud Mental), Madrid, Spain.
Saykin AJ Saykin Andrew J AJ Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Ehrlich S Ehrlich Stefan S Department of Child and Adolescent Psychiatry, Faculty of Medicine and University Hospital, Technische Universität Dresden, Dresden, Germany.
Mather KA Mather Karen A KA Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales (UNSW), Sydney, New South Wales, Australia.
Turner JA Turner Jessica A JA Mind Research Network, Albuquerque, New Mexico, USA.
Schwarz E Schwarz Emanuel E Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.
Thalamuthu A Thalamuthu Anbupalam A Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales (UNSW), Sydney, New South Wales, Australia.
Yao Y Yao Yin Y Intramural Research Program, National Institutes of Health, US Department of Health &Human Services, Bethesda, Maryland, USA.
Ho YY Ho Yvonne Y W YY QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Wright MJ Wright Margaret J MJ School of Psychology, University of Queensland, Brisbane, Queensland, Australia.
Schizophrenia Working Group of the Psychiatric Genomics Consortium
Psychosis Endophenotypes International Consortium
Wellcome Trust Case Control Consortium 2
Enigma Consortium
O'Donovan MC O'Donovan Michael C MC National Centre for Mental Health, Cardiff University, Cardiff, UK.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Mark and Mary Stevens Neuroimaging &Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA.
Neale BM Neale Benjamin M BM Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Medland SE Medland Sarah E SE QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Sullivan PF Sullivan Patrick F PF Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Adolfsson Rolf R
Andreassen Ole A OA
Blackwood Douglas H R DH
Børglum Anders D AD
Bramon Elvira E
Buxbaum Joseph D JD
Cichon Sven S
Darvasi Ariel A
Domenici Enrico E
Ehrenreich Hannelore H
Esko Tõnu T
Gejman Pablo V PV
Gill Michael M
Gurling Hugh H
Hultman Christina M CM
Iwata Nakao N
Jablensky Assen V AV
Jönsson Erik G EG
Kendler Kenneth S KS
Kirov George G
Knight Jo J
Lencz Todd T
Levinson Douglas F DF
Li Qingqin S QS
Liu Jianjun J
Malhotra Anil K AK
McCarroll Steven A SA
McQuillin Andrew A
Moran Jennifer L JL
Mortensen Preben B PB
Mowry Bryan J BJ
Nöthen Markus M MM
Ophoff Roel A RA
Owen Michael J MJ
Palotie Aarno A
Pato Carlos N CN
Petryshen Tracey L TL
Posthuma Danielle D
Rietschel Marcella M
Riley Brien P BP
Rujescu Dan D
Sham Pak C PC
Sklar Pamela P
St Clair David D
Weinberger Daniel R DR
Wendland Jens R JR
Werge Thomas T
Daly Mark J MJ
Sullivan Patrick F PF
O'Donovan Michael C MC
Hibar Derrek P DP
Stein Jason L JL
Renteria Miguel E ME
Arias-Vasquez Alejandro A
Desrivières Sylvane S
Jahanshad Neda N
Toro Roberto R
Wittfeld Katharina K
Abramovic Lucija L
Andersson Micael M
Aribisala Benjamin S BS
Armstrong Nicola J NJ
Bernard Manon M
Bohlken Marc M MM
Boks Marco P MP
Bralten Janita J
Brown Andrew A AA
Chakravarty M Mallar MM
Chen Qiang Q
Ching Christopher R K CR
Cuellar-Partida Gabriel G
den Braber Anouk A
Giddaluru Sudheer S
Goldman Aaron L AL
Grimm Oliver O
Guadalupe Tulio T
Hass Johanna J
Woldehawariat Girma G
Holmes Avram J AJ
Hoogman Martine M
Janowitz Deborah D
Jia Tianye T
Kim Sungeun S
Klein Marieke M
Kraemer Bernd B
Lee Phil P
Loohuis Loes M Olde LM
Luciano Michelle M
Macare Christine C
Mather Karen A KA
Mattheisen Manuel M
Milaneschi Yuri Y
Nho Kwangsik K
Papmeyer Martina M
Ramasamy Adaikalavan A
Risacher Shannon L SL
Roiz-Santiañez Roberto R
Rose Emma J EJ
Salami Alireza A
Sämann Philipp G PG
Schmaal Lianne L
Schork Andrew J AJ
Shin Jean J
Strike Lachlan T LT
Teumer Alexander A
van Donkelaar Marjolein M J MM
van Eijk Kristel R KR
Walters Raymond K RK
Westlye Lars T LT
Whelan Christopher D CD
Winkler Anderson M AM
Zwiers Marcel P MP
Alhusaini Saud S
Athanasiu Lavinia L
Ehrlich Stefan S
Hakobjan Marina M H MM
Hartberg Cecilie B CB
Haukvik Unn U
Heister Angelien J G A M AJ
Höhn David D
Kasperaviciute Dalia D
Liewald David C M DC
Lopez Lorna M LM
Makkinje Remco R R RR
Matarin Mar M
Naber Marlies A M MA
McKay David R DR
Needham Margaret M
Nugent Allison C AC
Pütz Benno B
Royle Natalie A NA
Shen Li L
Sprooten Emma E
Trabzuni Daniah D
van der Marel Saskia S L SS
van Hulzen Kimm J E KJ
Walton Esther E
Wolf Christiane C
Almasy Laura L
Ames David D
Arepalli Sampath S
Assareh Amelia A AA
Bastin Mark E ME
Brodaty Henry H
Bulayeva Kazima B KB
Carless Melanie A MA
Cichon Sven S
Corvin Aiden A
Curran Joanne E JE
Czisch Michael M
de Zubicaray Greig I GI
Dillman Allissa A
Duggirala Ravi R
Dyer Thomas D TD
Erk Susanne S
Fedko Iryna O IO
Ferrucci Luigi L
Foroud Tatiana M TM
Fox Peter T PT
Fukunaga Masaki M
Gibbs Raphael R
Göring Harald H H HH
Green Robert C RC
Guelfi Sebastian S
Hansell Narelle K NK
Hartman Catharina A CA
Hegenscheid Katrin K
Heinz Andreas A
Hernandez Dena G DG
Heslenfeld Dirk J DJ
Hoekstra Pieter J PJ
Holsboer Florian F
Homuth Georg G
Hottenga Jouke-Jan JJ
Ikeda Masashi M
Jack Clifford R CR
Jenkinson Mark M
Johnson Robert R
Kanai Ryota R
Keil Maria M
Kent Jack W JW
Kochunov Peter P
Kwok John B JB
Lawrie Stephen M SM
Liu Xinmin X
Longo Dan L DL
McMahon Katie L KL
Meisenzahl Eva E
Melle Ingrid I
Mohnke Sebastian S
Montgomery Grant W GW
Mostert Jeanette C JC
Mühleisen Thomas W TW
Nalls Michael A MA
Nichols Thomas E TE
Nilsson Lars G LG
Nöthen Markus M MM
Ohi Kazutaka K
Olvera Rene L RL
Perez-Iglesias Rocio R
Pike G Bruce GB
Potkin Steven G SG
Reinvang Ivar I
Reppermund Simone S
Rietschel Marcella M
Romanczuk-Seiferth Nina N
Rosen Glenn D GD
Rujescu Dan D
Schnell Knut K
Schofield Peter R PR
Smith Colin C
Steen Vidar M VM
Sussmann Jessika E JE
Thalamuthu Anbupalam A
Toga Arthur W AW
Traynor Bryan B
Troncoso Juan J
Turner Jessica A JA
Hernández Maria C Valdés MC
Ent Dennis van 't DV
van der Brug Marcel M
van der Wee Nic J A NJ
van Tol Marie-Jose MJ
Veltman Dick J DJ
Wassink Thomas H TH
Westman Eric E
Zielke Ronald H RH
Zonderman Alan A
Ashbrook David G DG
Hager Reinmar R
Lu Lu L
McMahon Francis J FJ
Morris Derek W DW
Williams Robert W RW
Brunner Han G HG
Buckner Randy L RL
Buitelaar Jan K JK
Cahn Wiepke W
Calhoun Vince D VD
Cavalleri Gianpiero L GL
Crespo-Facorro Benedicto B
Dale Anders M AM
Davies Gareth E GE
Delanty Norman N
Depondt Chantal C
Djurovic Srdjan S
Drevets Wayne C WC
Espeseth Thomas T
Gollub Randy L RL
Ho Beng-Choon BC
Hoffmann Wolfgang W
Hosten Norbert N
Kahn René S RS
LeHellard Stephanie S
Meyer-Lindenberg Andreas A
Müller-Myhsok Bertram B
Nauck Matthias M
Nyberg Lars L
Pandolfo Massimo M
Penninx Brenda W J H BW
Roffman Joshua L JL
Sisodiya Sanjay M SM
Smoller Jordan W JW
van Bokhoven Hans H
van Haren Neeltje E M NE
Völzke Henry H
Walter Henrik H
Weiner Michael W MW
Wen Wei W
White Tonya T
Agartz Ingrid I
Andreassen Ole A OA
Blangero John J
Boomsma Dorret I DI
Brouwer Rachel M RM
Cannon Dara M DM
Cookson Mark R MR
de Geus Eco J C EJ
Deary Ian J IJ
Donohoe Gary G
Fernández Guillén G
Fisher Simon E SE
Francks Clyde C
Glahn David C DC
Grabe Hans J HJ
Gruber Oliver O
Hardy John J
Hashimoto Ryota R
Hulshoff Pol Hilleke E HE
Jönsson Erik G EG
Kloszewska Iwona I
Lovestone Simon S
Mattay Venkata S VS
Mecocci Patrizia P
McDonald Colm C
McIntosh Andrew M AM
Ophoff Roel A RA
Paus Tomas T
Pausova Zdenka Z
Ryten Mina M
Sachdev Perminder S PS
Saykin Andrew J AJ
Simmons Andy A
Singleton Andrew A
Soininen Hilkka H
Wardlaw Joanna M JM
Weale Michael E ME
Weinberger Daniel R DR
Adams Hieab H H HH
Launer Lenore J LJ
Seiler Stephan S
Schmidt Reinhold R
Chauhan Ganesh G
Satizabal Claudia L CL
Becker James T JT
Yanek Lisa L
van der Lee Sven J SJ
Ebling Maritza M
Fischl Bruce B
Longstreth W T WT
Greve Douglas D
Schmidt Helena H
Nyquist Paul P
Vinke Louis N LN
van Duijn Cornelia M CM
Luting Xue X
Mazoyer Bernard B
Bis Joshua C JC
Gudnason Vilmundur V
Seshadri Sudha S
Ikram M Arfan MA
Martin Nicholas G NG
Wright Margaret J MJ
Schumann Gunter G
Franke Barbara B
Thompson Paul M PM
Medland Sarah E SE
JOURNAL
VOLUME:
ISSUE:
TITLE: Nature neuroscience
ISOABBREVIATION: Nat. Neurosci.
YEAR: 2016
MONTH: Feb
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1726
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Neurosci
COUNTRY: United States
ISSNLINKING: 1097-6256
NLMUNIQUEID: 9809671
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JOURNAL ARTICLE
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