Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
268313
TITLE
The genetical analysis of covariance structure.
ABSTRACT
The analysis of covariance structures (Jöreskog, 1973) is adapted to the simultaneous maximum likelihood estimation of genetical and environmental factor loadings and specific variances. The goodness of fit is tested by chi square and standard errors of parameter estimates can be obtained. Any linear model used in univariate genetical analyses can be extended to the multivariate case. Most biological hypotheses about the relationships between variables can be specified by a variety of factor models. Individual parameters can be given fixed values or set to zero and hypotheses concerning the congruence of genetical and environmental correlations can be tested. The method is illustrated with published twin data on cognitive abilities.
DATE PUBLISHED
1977 Feb
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1977/02/01
medline 1977/02/01 00:01
entrez 1977/02/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Martin NG Martin N G NG
Eaves LJ Eaves L J LJ
INVESTIGATORS
JOURNAL
VOLUME: 38
ISSUE: 1
TITLE: Heredity
ISOABBREVIATION: Heredity (Edinb)
YEAR: 1977
MONTH: Feb
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0018-067X
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Heredity (Edinb)
COUNTRY: England
ISSNLINKING: 0018-067X
NLMUNIQUEID: 0373007
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Factor Analysis, Statistical
Genetic Variation
Mathematics
Models, Biological
Phenotype
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's