Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26811803
TITLE
The variance shared across forms of childhood trauma is strongly associated with liability for psychiatric and substance use disorders.
ABSTRACT
INTRODUCTION NlmCategory: BACKGROUND
Forms of childhood trauma tend to co-occur and are associated with increased risk for psychiatric and substance use disorders. Commonly used binary measures of trauma exposure have substantial limitations.
METHODS NlmCategory: METHODS
We performed multigroup confirmatory factor analysis (CFA), separately by sex, using data from the Childhood Trauma (CT) Study's sample of twins and siblings (N = 2594) to derive three first-order factors (childhood physical abuse, childhood sexual abuse, and parental partner abuse) and, as hypothesized, one higher order, childhood trauma factor (CTF) representing a measure of their common variance.
RESULTS NlmCategory: RESULTS
CFA produced a good-fitting model in the CT Study; we replicated the model in the Comorbidity and Trauma (CAT) Study's sample (N = 1981) of opioid-dependent cases and controls. In both samples, first-order factors are moderately correlated (indicating they measure largely unique, but related constructs) and their loadings on the CTF suggest it provides a reasonable measure of their common variance. We examined the association of CTF score with risk for psychiatric and substance use disorders in these samples and the OZ-ALC GWAS sample (N = 1538) in which CT Study factor loadings were applied. We found that CTF scores are strongly associated with liability for psychiatric and substance use disorders in all three samples; estimates of risk are extremely consistent across samples.
CONCLUSIONS NlmCategory: CONCLUSIONS
The CTF is a continuous, robust measure that captures the common variance across forms of childhood trauma and provides a means to estimate shared liability while avoiding multicollinearity.
DATE PUBLISHED
2016 Jan 21
HISTORY
PUBSTATUS PUBSTATUSDATE
ecollection 2016/01
received 2015/07/23
revised 2015/09/25
accepted 2015/12/16
entrez 2016/01/27 06:00
pubmed 2016/01/27 06:00
medline 2016/01/27 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Kristjansson S Kristjansson Sean S Alcoholism Research Center Washington University School of Medicine St. Louis Missouri 63110.
McCutcheon VV McCutcheon Vivia V VV Alcoholism Research Center Washington University School of Medicine St. Louis Missouri 63110.
Agrawal A Agrawal Arpana A Alcoholism Research Center Washington University School of Medicine St. Louis Missouri 63110.
Lynskey MT Lynskey Michael T MT Institute of Psychiatry, Psychology, and Neuroscience King's College London UK.
Conroy E Conroy Elizabeth E Centre for Health Research University of Western Sydney Sydney Australia.
Statham DJ Statham Dixie J DJ QIMR Berghofer Medical Research Institute Brisbane Australia.
Madden PA Madden Pamela A F PA Alcoholism Research Center Washington University School of Medicine St. Louis Missouri 63110.
Henders AK Henders Anjali K AK QIMR Berghofer Medical Research Institute Brisbane Australia.
Todorov AA Todorov Alexandre A AA Alcoholism Research Center Washington University School of Medicine St. Louis Missouri 63110.
Bucholz KK Bucholz Kathleen K KK Alcoholism Research Center Washington University School of Medicine St. Louis Missouri 63110.
Degenhardt L Degenhardt Louisa L National Drug and Alcohol Research Center University of New South Wales Sydney Australia.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute Brisbane Australia.
Heath AC Heath Andrew C AC Alcoholism Research Center Washington University School of Medicine St. Louis Missouri 63110.
Nelson EC Nelson Elliot C EC Alcoholism Research Center Washington University School of Medicine St. Louis Missouri 63110.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Brain and behavior
ISOABBREVIATION: Brain Behav
YEAR: 2016
MONTH: Jan
DAY: 21
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2162-3279
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Brain Behav
COUNTRY:
ISSNLINKING:
NLMUNIQUEID: 101570837
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Childhood trauma
confirmatory factor analysis
substance use disorders
MESH HEADINGS
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