Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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26747746
TITLE
Heritability and reliability of automatically segmented human hippocampal formation subregions.
ABSTRACT
The human hippocampal formation can be divided into a set of cytoarchitecturally and functionally distinct subregions, involved in different aspects of memory formation. Neuroanatomical disruptions within these subregions are associated with several debilitating brain disorders including Alzheimer's disease, major depression, schizophrenia, and bipolar disorder. Multi-center brain imaging consortia, such as the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) consortium, are interested in studying disease effects on these subregions, and in the genetic factors that affect them. For large-scale studies, automated extraction and subsequent genomic association studies of these hippocampal subregion measures may provide additional insight. Here, we evaluated the test-retest reliability and transplatform reliability (1.5T versus 3T) of the subregion segmentation module in the FreeSurfer software package using three independent cohorts of healthy adults, one young (Queensland Twins Imaging Study, N=39), another elderly (Alzheimer's Disease Neuroimaging Initiative, ADNI-2, N=163) and another mixed cohort of healthy and depressed participants (Max Planck Institute, MPIP, N=598). We also investigated agreement between the most recent version of this algorithm (v6.0) and an older version (v5.3), again using the ADNI-2 and MPIP cohorts in addition to a sample from the Netherlands Study for Depression and Anxiety (NESDA) (N=221). Finally, we estimated the heritability (h(2)) of the segmented subregion volumes using the full sample of young, healthy QTIM twins (N=728). Test-retest reliability was high for all twelve subregions in the 3T ADNI-2 sample (intraclass correlation coefficient (ICC)=0.70-0.97) and moderate-to-high in the 4T QTIM sample (ICC=0.5-0.89). Transplatform reliability was strong for eleven of the twelve subregions (ICC=0.66-0.96); however, the hippocampal fissure was not consistently reconstructed across 1.5T and 3T field strengths (ICC=0.47-0.57). Between-version agreement was moderate for the hippocampal tail, subiculum and presubiculum (ICC=0.78-0.84; Dice Similarity Coefficient (DSC)=0.55-0.70), and poor for all other subregions (ICC=0.34-0.81; DSC=0.28-0.51). All hippocampal subregion volumes were highly heritable (h(2)=0.67-0.91). Our findings indicate that eleven of the twelve human hippocampal subregions segmented using FreeSurfer version 6.0 may serve as reliable and informative quantitative phenotypes for future multi-site imaging genetics initiatives such as those of the ENIGMA consortium.
Copyright 2016 The Authors. Published by Elsevier Inc. All rights reserved.
DATE PUBLISHED
2016 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/07/29
revised 2015/11/28
accepted 2015/12/23
aheadofprint 2015/12/30
entrez 2016/01/10 06:00
pubmed 2016/01/10 06:00
medline 2016/01/10 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Whelan CD Whelan Christopher D CD Imaging Genetics Center, University of Southern California, Marina del Rey, CA, USA.
Hibar DP Hibar Derrek P DP Imaging Genetics Center, University of Southern California, Marina del Rey, CA, USA.
van Velzen LS van Velzen Laura S LS Department of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
Zannas AS Zannas Anthony S AS Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
Carrillo-Roa T Carrillo-Roa Tania T Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
McMahon K McMahon Katie K Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.
Prasad G Prasad Gautam G Imaging Genetics Center, University of Southern California, Marina del Rey, CA, USA.
Kelly S Kelly Sinéad S Imaging Genetics Center, University of Southern California, Marina del Rey, CA, USA.
Faskowitz J Faskowitz Joshua J Imaging Genetics Center, University of Southern California, Marina del Rey, CA, USA.
deZubiracay G deZubiracay Greig G Faculty of Health, Queensland University of Technology, Brisbane, Australia.
Iglesias JE Iglesias Juan E JE Basque Center on Cognition, Brain and Language, Donostia, Gipuzkoa, Spain.
van Erp TG van Erp Theo G M TG Department of Psychiatry and Human Behavior, University of California, Irvine, USA.
Frodl T Frodl Thomas T Department of Psychiatry, Otto-von Guericke-University of Magdeburg, Germany.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Wright MJ Wright Margaret J MJ Queensland Brain Institute, University of Queensland, Brisbane, Australia.
Jahanshad N Jahanshad Neda N Imaging Genetics Center, University of Southern California, Marina del Rey, CA, USA.
Schmaal L Schmaal Lianne L Department of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center and GGZ inGeest, Amsterdam, The Netherlands.
Sämann PG Sämann Philipp G PG Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Thompson PM Thompson Paul M PM Imaging Genetics Center, University of Southern California, Marina del Rey, CA, USA. Electronic address: pthomp@usc.edu.
Alzheimer's Disease Neuroimaging Initiative
INVESTIGATORS
JOURNAL
VOLUME: 128
ISSUE:
TITLE: NeuroImage
ISOABBREVIATION: Neuroimage
YEAR: 2016
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1095-9572
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neuroimage
COUNTRY: United States
ISSNLINKING: 1053-8119
NLMUNIQUEID: 9215515
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
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