Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26482879
TITLE
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
ABSTRACT
Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.
DATE PUBLISHED
2015 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/03/20
accepted 2015/09/25
aheadofprint 2015/10/19
entrez 2015/10/21 06:00
pubmed 2015/10/21 06:00
medline 2015/10/21 06:00
pmc-release 2016/06/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
EArly Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium
Australian Asthma Genetics Consortium(AAGC)
Australian Asthma Genetics Consortium AAGC
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Ried Janina S JS
Li Jin J
Zuo Xian Bo XB
Zheng Xiao Dong XD
Yin Xian Yong XY
Sun Liang Dan LD
McAleer Maeve A MA
O'Regan Grainne M GM
Fahy Caoimhe M R CM
Campbell Linda E LE
Macek Milan M
Kurek Michael M
Hu Donglei D
Eng Celeste C
Postma Dirkje S DS
Feenstra Bjarke B
Geller Frank F
Hottenga Jouke Jan JJ
Middeldorp Christel M CM
Hysi Pirro P
Bataille Veronique V
Spector Tim T
Tiesler Carla M T CM
Thiering Elisabeth E
Pahukasahasram Badri B
Yang James J JJ
Imboden Medea M
Huntsman Scott S
Vilor-Tejedor Natàlia N
Relton Caroline L CL
Myhre Ronny R
Nystad Wenche W
Custovic Adnan A
Weiss Scott T ST
Meyers Deborah A DA
Söderhäll Cilla C
Melén Erik E
Ober Carole C
Raby Benjamin A BA
Simpson Angela A
Jacobsson Bo B
Holloway John W JW
Bisgaard Hans H
Sunyer Jordi J
Probst-Hensch Nicole M NM
Williams L Keoki LK
Godfrey Keith M KM
Wang Carol A CA
Boomsma Dorret I DI
Melbye Mads M
Koppelman Gerard H GH
Jarvis Deborah D
McLean W H Irwin WH
Irvine Alan D AD
Zhang Xue Jun XJ
Hakonarson Hakon H
Gieger Christian C
Burchard Esteban G EG
Martin Nicholas G NG
Duijts Liesbeth L
Linneberg Allan A
Jarvelin Marjo-Riitta MR
Nöthen Markus M MM
Lau Susanne S
Hübner Norbert N
Lee Young-Ae YA
Tamari Mayumi M
Hinds David A DA
Glass Daniel D
Brown Sara J SJ
Heinrich Joachim J
Evans David M DM
Weidinger Stephan S
JOURNAL
VOLUME: 47
ISSUE: 12
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2015
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Nat Genet. 2013 Jul;45(7):730-8 23749187
Cites Nat Genet. 2013 Aug;45(8):907-11 23817569
Cites Nat Genet. 2013 Aug;45(8):902-6 23817571
Cites J Allergy Clin Immunol. 2013 Aug;132(2):371-7 23582566
Cites Cell. 2013 Sep 26;155(1):70-80 24074861
Cites Nat Rev Immunol. 2014 Jun;14(6):417-28 24854591
Cites J Allergy Clin Immunol. 2014 Jun;133(6):1564-71 24388013
Cites N Engl J Med. 2014 Jul 10;371(2):130-9 25006719
Cites J Allergy Clin Immunol. 2014 Jul;134(1):82-91 24880632
Cites Am J Hum Genet. 2015 Jan 8;96(1):104-20 25574825
Cites J Cell Sci. 2010 Oct 15;123(Pt 20):3566-75 20930145
Cites Nat Biotechnol. 2010 Oct;28(10):1045-8 20944595
Cites Trends Immunol. 2010 Dec;31(12):452-9 21030306
Cites Nat Genet. 2011 Jul;43(7):690-4 21666691
Cites PLoS Genet. 2011 Jul;7(7):e1002170 21814517
Cites Nature. 2011 Aug 11;476(7359):214-9 21833088
Cites Genet Epidemiol. 2011 Sep;35(6):447-56 21618601
Cites Nat Genet. 2011 Sep;43(9):893-6 21804548
Cites J Allergy Clin Immunol. 2011 Sep;128(3):583-93.e1-4 21762976
Cites Lancet. 2011 Sep 10;378(9795):1006-14 21907864
Cites Cell. 2011 Sep 30;147(1):32-43 21962505
Cites PLoS Genet. 2011 Sep;7(9):e1002293 21980299
Cites N Engl J Med. 2011 Oct 6;365(14):1315-27 21991953
Cites J Allergy Clin Immunol. 2011 Nov;128(5):996-1005 22036096
Cites Genet Epidemiol. 2011 Dec;35(8):809-22 22125221
Cites Nat Genet. 2012 Feb;44(2):187-92 22197932
Cites J Allergy Clin Immunol. 2012 Mar;129(3):840-845.e21 22075330
Cites Annu Rev Immunol. 2012;30:95-114 22149933
Cites Nat Genet. 2012 Apr;44(4):369-75, S1-3 22426310
Cites J Allergy Clin Immunol. 2012 May;129(5):1209-1215.e2 22409986
Cites Semin Immunol. 2012 Jun;24(3):218-24 22410365
Cites J Immunol. 2012 Aug 1;189(3):1193-201 22753944
Cites J Eur Acad Dermatol Venereol. 2012 Sep;26(9):1067-73 22243446
Cites Nature. 2012 Sep 6;489(7414):57-74 22955616
Cites Science. 2012 Sep 7;337(6099):1190-5 22955828
Cites Nat Genet. 2012 Oct;44(10):1084-9 22941192
Cites Nat Genet. 2012 Nov;44(11):1222-6 23042114
Cites Nature. 2012 Nov 1;491(7422):119-24 23128233
Cites Nat Genet. 2012 Dec;44(12):1341-8 23143594
Cites Nat Genet. 2012 Dec;44(12):1294-301 23104008
Cites J Crohns Colitis. 2013 Feb;7(1):79-88 22748696
Cites Am J Hum Genet. 2004 Apr;74(4):765-9 14997420
Cites J Invest Dermatol. 2004 Nov;123(5):999-1000 15482492
Cites J Am Acad Dermatol. 1995 Jun;32(6):982-6 7751469
Cites J Invest Dermatol. 1998 May;110(5):740-5 9579538
Cites Hum Mol Genet. 2013 Dec 1;22(23):4841-56 23886662
Cites Nat Genet. 2013 Dec;45(12):1418-27 24141362
Cites Nucleic Acids Res. 2014 Jan;42(Database issue):D1001-6 24316577
Cites Nature. 2014 Feb 20;506(7488):376-81 24390342
Cites Blood. 2014 May 8;123(19):2978-87 24632714
Cites PLoS Genet. 2014 May;10(5):e1004383 24830394
Cites Gut. 2005 Mar;54(3):357-63 15710983
Cites Clin Exp Immunol. 2006 Apr;144(1):1-9 16542358
Cites Nat Genet. 2006 Apr;38(4):441-6 16550169
Cites Nat Genet. 2007 Sep;39(9):1108-13 17660816
Cites Nat Genet. 2007 Sep;39(9):1083-91 17660817
Cites Cancer Res. 2007 Nov 15;67(22):11001-11 18006846
Cites J Exp Med. 2007 Nov 26;204(12):2825-35 17967903
Cites N Engl J Med. 2008 Apr 3;358(14):1483-94 18385500
Cites Nature. 2008 Apr 10;452(7188):773-6 18337720
Cites Nat Genet. 2009 May;41(5):596-601 19349984
Cites Am J Hum Genet. 2009 May;84(5):581-93 19426955
Cites J Allergy Clin Immunol. 2009 Jun;123(6):1361-70.e7 19501237
Cites N Engl J Med. 2010 Jan 7;362(1):36-44 20032318
Cites PLoS Genet. 2010 Aug;6(8). pii: e1001058. doi: 10.1371/journal.pgen.1001058 20714348
Cites N Engl J Med. 2010 Sep 23;363(13):1211-21 20860503
Cites Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1761-70 23610432
Cites Hum Mol Genet. 2013 Jun 1;22(11):2303-11 23406875
Cites Nat Genet. 2013 Jul;45(7):808-12 23727859
GRANTS
GRANTID AGENCY COUNTRY
MC_UU_12013/2 Medical Research Council United Kingdom
MR/J012165/1 Medical Research Council United Kingdom
R01 AI118833 NIAID NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
EMS65321 [Available on 06/01/16] NLM
PMC4753676 [Available on 06/01/16] NLM