Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26463647
TITLE
Early onset alcohol use and self-harm: a discordant twin analysis.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Self-harm has considerable societal and economic costs and has been extensively studied in relation to alcohol involvement. Although early onset alcohol use (EAU) has been causally linked to maladaptive clinical outcomes, its association with self-harm is less well characterized. This study aimed to further examine the link between EAU and both nonsuicidal self-injury (NSSI) and suicide attempt (SA), and elucidate shared familial and causal/individual-specific pathways that explain this co-occurrence.
METHODS NlmCategory: METHODS
Using data from 6,082 Australian same-sex twin pairs (1,732 monozygotic [MZ] and 1,309 dizygotic [DZ]), ages 23 to 40, we examined prevalence rates of NSSI and SA among twin pairs concordant and discordant for EAU. Conditional logistic regression, controlling for early clinical covariates and the influence of zygosity on EAU, was used to examine the odds ratio (OR) of self-harm within twin pairs discordant for EAU.
RESULTS NlmCategory: RESULTS
Prevalence rates of both NSSI and SA were highest among twin pairs concordant for EAU and for twins who reported EAU within discordant twin pairs. Results from discordant twin analyses revealed nearly 4-fold increased odds of SA for the twin who endorsed EAU, and this OR was equal across MZ and DZ twins. EAU also was associated with elevated odds of NSSI (OR = 7.62), although this was only the case for DZ twins in discordant pairs.
CONCLUSIONS NlmCategory: CONCLUSIONS
The equivalent increase in odds of SA for both MZ and DZ twins suggests that causal or individual-specific influences explain the link between EAU and SA. For NSSI, elevated odds for DZ twins and nonsignificant findings for MZ twins implicate correlated genetic factors in the association between EAU and NSSI. Future studies should test mechanisms through which EAU may causally influence SA, as well as examine whether genetic risk for third variables (e.g., negative urgency, stress reactivity) may explain the genetic overlap between EAU and NSSI.
Copyright 2015 by the Research Society on Alcoholism.
DATE PUBLISHED
2015 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/05/19
accepted 2015/08/26
aheadofprint 2015/10/14
entrez 2015/10/15 06:00
pubmed 2015/10/16 06:00
medline 2015/10/16 06:00
pmc-release 2016/11/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Few LR Few Lauren R LR Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri.
Werner KB Werner Kimberly B KB George Warren Brown School of Social Work, Washington University, Saint Louis, Missouri.
Sartor CE Sartor Carolyn E CE Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut.
Grant JD Grant Julia D JD Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri.
Trull TJ Trull Timothy J TJ Department of Psychological Sciences, University of Missouri, Columbia, Missouri.
Nock MK Nock Matthew K MK Department of Psychology, Harvard University, Cambridge, Massachusetts.
Bucholz KK Bucholz Kathleen K KK Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri.
Deitz SK Deitz Sarah K SK Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri.
Glowinski AL Glowinski Anne L AL Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri.
Martin NG Martin Nicholas G NG QIMR Medical Research Institute, Brisbane, Queensland, Australia.
Nelson EC Nelson Elliot C EC Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri.
Statham DJ Statham Dixie J DJ School of Social Sciences, University of the Sunshine Coast, Sippy Downs, Queensland, Australia.
Madden PA Madden Pamela A F PA Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri.
Heath AC Heath Andrew C AC Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri.
Lynskey MT Lynskey Michael T MT Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Agrawal A Agrawal Arpana A Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri.
INVESTIGATORS
JOURNAL
VOLUME: 39
ISSUE: 11
TITLE: Alcoholism, clinical and experimental research
ISOABBREVIATION: Alcohol. Clin. Exp. Res.
YEAR: 2015
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1530-0277
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Alcohol Clin Exp Res
COUNTRY: England
ISSNLINKING: 0145-6008
NLMUNIQUEID: 7707242
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA017921 NIAAA NIH HHS United States
AA023549 NIAAA NIH HHS United States
AA023693 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA13221 NIAAA NIH HHS United States
AA21235 NIAAA NIH HHS United States
DA18267 NIDA NIH HHS United States
F32 AA023693 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Early Alcohol Use
Self-Harm
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS719363 [Available on 11/01/16] NLM
PMC4729363 [Available on 11/01/16] NLM