Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26366552
TITLE
Population genetic differentiation of height and body mass index across Europe.
ABSTRACT
NlmCategory: UNASSIGNED
Across-nation differences in the mean values for complex traits are common, but the reasons for these differences are unknown. Here we find that many independent loci contribute to population genetic differences in height and body mass index (BMI) in 9,416 individuals across 14 European countries. Using discovery data on over 250,000 individuals and unbiased effect size estimates from 17,500 sibling pairs, we estimate that 24% (95% credible interval (CI) = 9%, 41%) and 8% (95% CI = 4%, 16%) of the captured additive genetic variance for height and BMI, respectively, reflect population genetic differences. Population genetic divergence differed significantly from that in a null model (height, P < 3.94 x 10(-8); BMI, P < 5.95 x 10(-4)), and we find an among-population genetic correlation for tall and slender individuals (r = -0.80, 95% CI = -0.95, -0.60), consistent with correlated selection for both phenotypes. Observed differences in height among populations reflected the predicted genetic means (r = 0.51; P < 0.001), but environmental differences across Europe masked genetic differentiation for BMI (P < 0.58).
DATE PUBLISHED
2015 Sep 14
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/06/26
accepted 2015/08/19
entrez 2015/09/15 06:00
pubmed 2015/09/15 06:00
medline 2015/09/15 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Robinson MR Robinson Matthew R MR Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Hemani G Hemani Gibran G Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Medina-Gomez C Medina-Gomez Carolina C Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Mezzavilla M Mezzavilla Massimo M Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
Esko T Esko Tonu T Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Shakhbazov K Shakhbazov Konstantin K Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Powell JE Powell Joseph E JE University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.
Vinkhuyzen A Vinkhuyzen Anna A Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Berndt SI Berndt Sonja I SI Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Gustafsson S Gustafsson Stefan S Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Justice AE Justice Anne E AE Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Kahali B Kahali Bratati B Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
Locke AE Locke Adam E AE Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
Pers TH Pers Tune H TH Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.
Vedantam S Vedantam Sailaja S Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Wood AR Wood Andrew R AR Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
van Rheenen W van Rheenen Wouter W Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.
Andreassen OA Andreassen Ole A OA Norwegian Centre for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Gasparini P Gasparini Paolo P Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
Metspalu A Metspalu Andres A Estonian Genome Center, University of Tartu, Tartu, Estonia.
Berg LH Berg Leonard H van den LH Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.
Veldink JH Veldink Jan H JH Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.
Rivadeneira F Rivadeneira Fernando F Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Werge TM Werge Thomas M TM Lundbeck Foundation Initiative for Integrative Psychiatric Research, (iPSYCH), Aarhus, Denmark.
Abecasis GR Abecasis Goncalo R GR Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands.
Chasman DI Chasman Daniel I DI Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
de Geus EJ de Geus Eco J C EJ Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands.
Frayling TM Frayling Timothy M TM Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Hirschhorn JN Hirschhorn Joel N JN Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Hottenga JJ Hottenga Jouke Jan JJ Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands.
Ingelsson E Ingelsson Erik E Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Loos RJ Loos Ruth J F RJ Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Magnusson PK Magnusson Patrik K E PK Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Montgomery GW Montgomery Grant W GW QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
North KE North Kari E KE Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Spector TD Spector Timothy D TD Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK.
Speliotes EK Speliotes Elizabeth K EK Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
Goddard ME Goddard Michael E ME Department of Food and Agricultural Systems, University of Melbourne, Melbourne, Victoria, Australia.
Yang J Yang Jian J University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.
Visscher PM Visscher Peter M PM University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2015
MONTH: Sep
DAY: 14
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
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