Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26337138
TITLE
Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project.
ABSTRACT
A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.
DATE PUBLISHED
2015 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2015/09/04
entrez 2015/09/05 06:00
pubmed 2015/09/05 06:00
medline 2015/09/05 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Jelenkovic A
Yokoyama Y
Sund R
Honda C
Bogl LH
Aaltonen S
Ji F
Ning F
Pang Z
Ordonana JR
Sanchez-Romera JF
Colodro-Conde L
Burt SA
Klump KL
Medland SE
Montgomery GW
Kandler C
McAdams TA
Eley TC
Gregory AM
Saudino KJ
Dubois L
Boivin M
Tarnoki AD
Tarnoki DL
Haworth CM
Plomin R
Oncel SY
Aliev F
Stazi MA
Fagnani C
D'Ippolito C
Craig JM
Saffery R
Siribaddana SH
Hotopf M
Sumathipala A
Rijsdijk F
Spector T
Mangino M
Lachance G
Gatz M
Butler DA
Bayasgalan G
Narandalai D
Freitas DL
Maia JA
Harden KP
Tucker-Drob EM
Kim B
Chong Y
Hong C
Shin HJ
Christensen K
Skytthe A
Kyvik KO
Derom CA
Vlietinck RF
Loos RJ
Cozen W
Hwang AE
Mack TM
He M
Ding X
Chang B
Silberg JL
Eaves LJ
Maes HH
Cutler TL
Hopper JL
Aujard K
Magnusson PK
Pedersen NL
Aslan AK
Song YM
Yang S
Lee K
Baker LA
Tuvblad C
Bjerregaard-Andersen M
Beck-Nielsen H
Sodemann M
Heikkila K
Tan Q
Zhang D
Swan GE
Krasnow R
Jang KL
Knafo-Noam A
Mankuta D
Abramson L
Lichtenstein P
Krueger RF
McGue M
Pahlen S
Tynelius P
Duncan GE
Buchwald D
Corley RP
Huibregtse BM
Nelson TL
Whitfield KE
Franz CE
Kremen WS
Lyons MJ
Ooki S
Brandt I
Nilsen TS
Inui F
Watanabe M
Bartels M
van Beijsterveldt TC
Wardle J
Llewellyn CH
Fisher A
Rebato E
Martin NG
Iwatani Y
Hayakawa K
Sung J
Harris JR
Willemsen G
Busjahn A
Goldberg JH
Rasmussen F
Hur YM
Boomsma DI
Sorensen TI
Kaprio J
Silventoinen K
INVESTIGATORS
JOURNAL
VOLUME: 18
ISSUE: 5
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2015
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R21 AG039572 NIA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
BMI
height
twins
zygosity differences
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's