Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26281760
TITLE
The role of conduct disorder in the relationship between alcohol, nicotine and cannabis use disorders.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Genetic influences contribute significantly to co-morbidity between conduct disorder and substance use disorders. Estimating the extent of overlap can assist in the development of phenotypes for genomic analyses.
METHOD NlmCategory: METHODS
Multivariate quantitative genetic analyses were conducted using data from 9577 individuals, including 3982 complete twin pairs and 1613 individuals whose co-twin was not interviewed (aged 24-37 years) from two Australian twin samples. Analyses examined the genetic correlation between alcohol dependence, nicotine dependence and cannabis abuse/dependence and the extent to which the correlations were attributable to genetic influences shared with conduct disorder.
RESULTS NlmCategory: RESULTS
Additive genetic (a2 = 0.48-0.65) and non-shared environmental factors explained variance in substance use disorders. Familial effects on conduct disorder were due to additive genetic (a2 = 0.39) and shared environmental (c2 = 0.15) factors. All substance use disorders were influenced by shared genetic factors (r g = 0.38-0.56), with all genetic overlap between substances attributable to genetic influences shared with conduct disorder. Genes influencing individual substance use disorders were also significant, explaining 40-73% of the genetic variance per substance.
CONCLUSIONS NlmCategory: CONCLUSIONS
Among substance users in this sample, the well-documented clinical co-morbidity between conduct disorder and substance use disorders is primarily attributable to shared genetic liability. Interventions targeted at generally reducing deviant behaviors may address the risk posed by this shared genetic liability. However, there is also evidence for genetic and environmental influences specific to each substance. The identification of these substance-specific risk factors (as well as potential protective factors) is critical to the future development of targeted treatment protocols.
DATE PUBLISHED
2015 Aug 18
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2015/08/19 06:00
pubmed 2015/08/19 06:00
medline 2015/08/19 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Grant JD Grant J D JD Department of Psychiatry,Washington University School of Medicine,St Louis,MO,USA.
Lynskey MT Lynskey M T MT Institute of Psychiatry, Psychology & Neuroscience, Addictions Department,King's College London,London,UK.
Madden PA Madden P A F PA Department of Psychiatry,Washington University School of Medicine,St Louis,MO,USA.
Nelson EC Nelson E C EC Department of Psychiatry,Washington University School of Medicine,St Louis,MO,USA.
Few LR Few L R LR Department of Psychiatry,Washington University School of Medicine,St Louis,MO,USA.
Bucholz KK Bucholz K K KK Department of Psychiatry,Washington University School of Medicine,St Louis,MO,USA.
Statham DJ Statham D J DJ University of the Sunshine Coast,Queensland,Australia.
Martin NG Martin N G NG QIMR Berghofer Medical Research Institute,Queensland,Australia.
Heath AC Heath A C AC Department of Psychiatry,Washington University School of Medicine,St Louis,MO,USA.
Agrawal A Agrawal A A Department of Psychiatry,Washington University School of Medicine,St Louis,MO,USA.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Psychological medicine
ISOABBREVIATION: Psychol Med
YEAR: 2015
MONTH: Aug
DAY: 18
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1469-8978
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Psychol Med
COUNTRY: England
ISSNLINKING: 0033-2917
NLMUNIQUEID: 1254142
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Alcohol
cannabis
conduct disorder
genetic overlap
nicotine
substance use disorders
twins
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's