Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26242864
TITLE
Multicohort analysis of the maternal age effect on recombination.
ABSTRACT
Several studies have reported that the number of crossovers increases with maternal age in humans, but others have found the opposite. Resolving the true effect has implications for understanding the maternal age effect on aneuploidies. Here, we revisit this question in the largest sample to date using single nucleotide polymorphism (SNP)-chip data, comprising over 6,000 meioses from nine cohorts. We develop and fit a hierarchical model to allow for differences between cohorts and between mothers. We estimate that over 10 years, the expected number of maternal crossovers increases by 2.1% (95% credible interval (0.98%, 3.3%)). Our results are not consistent with the larger positive and negative effects previously reported in smaller cohorts. We see heterogeneity between cohorts that is likely due to chance effects in smaller samples, or possibly to confounders, emphasizing that care should be taken when interpreting results from any specific cohort about the effect of maternal age on recombination.
DATE PUBLISHED
2015
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/12/19
accepted 2015/06/18
entrez 2015/08/06 06:00
pubmed 2015/08/06 06:00
medline 2015/08/06 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Martin HC Martin Hilary C HC Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX17BN, UK.
Christ R Christ Ryan R Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX17BN, UK.
Hussin JG Hussin Julie G JG Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX17BN, UK.
O'Connell J O'Connell Jared J Illumina, Inc., Chesterford Research Park, Little Chesterford CB10 1XL, UK.
Gordon S Gordon Scott S QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Mbarek H Mbarek Hamdi H Department for Biological Psychiatry, Vrije Universiteit, Amsterdam 1081, The Netherlands.
Hottenga JJ Hottenga Jouke-Jan JJ Department for Biological Psychiatry, Vrije Universiteit, Amsterdam 1081, The Netherlands.
McAloney K McAloney Kerrie K QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Willemsen G Willemsen Gonnecke G Department for Biological Psychiatry, Vrije Universiteit, Amsterdam 1081, The Netherlands.
Gasparini P Gasparini Paolo P Institute for Maternal and Child Health-IRCCS Burlo Garofolo, University of Trieste, Trieste 34137, Italy.
Pirastu N Pirastu Nicola N Institute for Maternal and Child Health-IRCCS Burlo Garofolo, University of Trieste, Trieste 34137, Italy.
Montgomery GW Montgomery Grant W GW QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Navarro P Navarro Pau P MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Soranzo N Soranzo Nicole N Wellcome Trust Sanger Institute, Hinxton CB10 1HH, UK.
Toniolo D Toniolo Daniela D Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan 20132, Italy.
Vitart V Vitart Veronique V MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Wilson JF Wilson James F JF 1] MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK [2] Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Marchini J Marchini Jonathan J 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX17BN, UK [2] Department of Statistics, University of Oxford, Oxford OX1 3TG, UK.
Boomsma DI Boomsma Dorret I DI Department for Biological Psychiatry, Vrije Universiteit, Amsterdam 1081, The Netherlands.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Donnelly P Donnelly Peter P 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX17BN, UK [2] Department of Statistics, University of Oxford, Oxford OX1 3TG, UK.
INVESTIGATORS
JOURNAL
VOLUME: 6
ISSUE:
TITLE: Nature communications
ISOABBREVIATION: Nat Commun
YEAR: 2015
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2041-1723
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Commun
COUNTRY: England
ISSNLINKING: 2041-1723
NLMUNIQUEID: 101528555
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
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