Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
26231222
TITLE
Shared genetics underlying epidemiological association between endometriosis and ovarian cancer.
ABSTRACT
NlmCategory: UNASSIGNED
Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid carcinomas. We aimed to determine whether the observed associations might be due to shared genetic aetiology. To address this, we used two endometriosis datasets genotyped on common arrays with full-genome coverage (3,194 cases and 7,060 controls) and a large ovarian cancer dataset genotyped on the customised iCOGS arrays (10,065 cases and 21,663 controls). Previous work has suggested that a large number of genetic variants contribute to endometriosis and ovarian cancer (all histotypes combined) susceptibility. Here using the iCOGS data, we confirmed polygenic architecture for most histotypes of ovarian cancer. This led us to evaluate if the polygenic effects are shared across diseases. We found evidence for shared genetic risks between endometriosis and all histotypes of ovarian cancer, except for the intestinal mucinous type. Clear cell carcinoma showed the strongest genetic correlation with endometriosis (0.51, 95% CI=0.18-0.84). Endometrioid and low-grade serous carcinomas had similar correlation coefficients (0.48, 95% CI=0.07-0.89 and 0.40, 95% CI=0.05-0.75, respectively). High-grade serous carcinoma, which often arises from the fallopian tubes, showed a weaker genetic correlation with endometriosis (0.25, 95% CI=0.11-0.39), despite the absence of a known epidemiological association. These results suggest that the epidemiological association between endometriosis and ovarian adenocarcinoma may be attributable to shared genetic susceptibility loci.
The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
DATE PUBLISHED
2015 Jul 30
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2015/08/02 06:00
pubmed 2015/08/02 06:00
medline 2015/08/02 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Lu Y Lu Yi Y Statistical Genetics, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD 4006, Australia.
Cuellar G Cuellar Gabriel G Statistical Genetics, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD 4006, Australia.
Painter JN Painter Jodie N JN Molecular Cancer Epidemiology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD 4006, Australia.
Nyholt D Nyholt Dale D Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia.
Australian Ovarian Cancer Study
International Endogene Consortium (IEC)
Morris AP Morris Andrew P AP Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Fasching PA Fasching Peter A PA University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Hein A Hein Alexander A University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Burghaus S Burghaus Stefanie S University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Beckmann MW Beckmann Matthias W MW University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Lambrechts D Lambrechts Diether D Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium Vesalius Research Center, VIB, Leuven, Belgium.
Van Nieuwenhuysen E Van Nieuwenhuysen Els E Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Vergote I Vergote Ignace I Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Vanderstichele A Vanderstichele Adriaan A Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Doherty JA Doherty Jennifer Anne JA Department of Community and Family Medicine, Section of Biostatistics & Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Rossing MA Rossing Mary Anne MA Department of Epidemiology, University of Washington, Seattle, WA, USA Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Wicklund KG Wicklund Kristine G KG Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Chang-Claude J Chang-Claude Jenny J German Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany.
Eilber U Eilber Ursula U German Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany.
Rudolph A Rudolph Anja A German Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany.
Wang-Gohrke S Wang-Gohrke Shan S Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany.
Goodman MT Goodman Marc T MT Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Bogdanova N Bogdanova Natalia N Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany.
Dörk T Dörk Thilo T Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Dürst M Dürst Matthias M Department of Gynecology, Jena-University Hospital-Friedrich Schiller University, Jena, Germany.
Hillemanns P Hillemanns Peter P Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
Runnebaum IB Runnebaum Ingo B IB Department of Gynecology, Jena-University Hospital-Friedrich Schiller University, Jena, Germany.
Antonenkova N Antonenkova Natalia N N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus.
Butzow R Butzow Ralf R Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Leminen A Leminen Arto A Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Nevanlinna H Nevanlinna Heli H Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Pelttari LM Pelttari Liisa M LM Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Edwards RP Edwards Robert P RP Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Kelley JL Kelley Joseph L JL Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Modugno F Modugno Francesmary F Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
Moysich KB Moysich Kirsten B KB Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
Ness RB Ness Roberta B RB The University of Texas School of Public Health, Houston, TX, USA.
Cannioto R Cannioto Rikki R Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
Høgdall E Høgdall Estrid E Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Jensen A Jensen Allan A Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Giles GG Giles Graham G GG Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Bruinsma F Bruinsma Fiona F Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Kjaer SK Kjaer Susanne K SK Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Hildebrandt MA Hildebrandt Michelle A T MA Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Liang D Liang Dong D College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA.
Lu KH Lu Karen H KH Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Wu X Wu Xifeng X Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Bisogna M Bisogna Maria M Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Dao F Dao Fanny F Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Levine DA Levine Douglas A DA Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Cramer DW Cramer Daniel W DW Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Terry KL Terry Kathryn L KL Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Tworoger SS Tworoger Shelley S SS Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Missmer S Missmer Stacey S Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Bjorge L Bjorge Line L Department of Gynecology and Obstetrics, Haukeland University Horpital, Bergen, Norway Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
Salvesen HB Salvesen Helga B HB Department of Gynecology and Obstetrics, Haukeland University Horpital, Bergen, Norway Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
Kopperud RK Kopperud Reidun K RK Department of Gynecology and Obstetrics, Haukeland University Horpital, Bergen, Norway Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
Bischof K Bischof Katharina K Department of Gynecology and Obstetrics, Haukeland University Horpital, Bergen, Norway Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
Aben KK Aben Katja K H KK Radboud University Medical Centre, Radbond Institute for Health Sciences, Nijmegen, Netherlands Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands.
Kiemeney LA Kiemeney Lambertus A LA Radboud University Medical Centre, Radbond Institute for Health Sciences, Nijmegen, Netherlands.
Massuger LF Massuger Leon F A G LF Radboud university medical center, Radboud Institute for Molecular Life Sciences, Department of Obstetrics and Gynaecology, Nijmegen, The Netherlands.
Brooks-Wilson A Brooks-Wilson Angela A Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC Canada.
Olson SH Olson Sara H SH Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY, USA.
McGuire V McGuire Valerie V Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA.
Rothstein JH Rothstein Joseph H JH Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA.
Sieh W Sieh Weiva W Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA.
Whittemore AS Whittemore Alice S AS Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA.
Cook LS Cook Linda S LS Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA.
Le ND Le Nhu D ND Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada.
Gilks CB Gilks C Blake CB Pathology and Laboratory Medicine, University of British Columbia, Vancouver BC, Canada.
Gronwald J Gronwald Jacek J International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jakubowska A Jakubowska Anna A International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Lubiński J Lubiński Jan J International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Gawełko J Gawełko Jan J Intitute of Nursing and Health Sciences, Medical Faculty, University of Rzeszów, Poland.
Song H Song Honglin H The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Tyrer JP Tyrer Jonathan P JP The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Wentzensen N Wentzensen Nicolas N Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD, USA.
Brinton L Brinton Louise L Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD, USA.
Trabert B Trabert Britton B Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD, USA.
Lissowska J Lissowska Jolanta J M. Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland.
McLaughlin JR McLaughlin John R JR Public Health Ontario, Toronto, ON, Canada.
Narod SA Narod Steven A SA Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada.
Phelan C Phelan Catherine C Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Anton-Culver H Anton-Culver Hoda H Department of Epidemiology, University of California Irvine, Irvine, California, USA Center for Cancer Genetics Research & Prevention, School of Medicine, University of California Irvine, Irvine, California, USA.
Ziogas A Ziogas Argyrios A Department of Epidemiology, University of California Irvine, Irvine, California, USA.
Eccles D Eccles Diana D Faculty of Medicine, University of Southampton, Southampton, UK.
Gayther SA Gayther Simon A SA Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Gentry-Maharaj A Gentry-Maharaj Aleksandra A Women's Cancer, Institute for Women's Health, University College London, London, United Kingdom.
Menon U Menon Usha U Women's Cancer, Institute for Women's Health, University College London, London, United Kingdom.
Ramus SJ Ramus Susan J SJ Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Wu AH Wu Anna H AH Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Dansonka-Mieszkowska A Dansonka-Mieszkowska Agnieszka A Department of Pathology and Laboratory Diagnostics, the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Kupryjanczyk J Kupryjanczyk Jolanta J Department of Pathology and Laboratory Diagnostics, the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Timorek A Timorek Agnieszka A Department of Obstetrics, Gynecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland.
Szafron L Szafron Lukasz L Department of Pathology and Laboratory Diagnostics, the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Cunningham JM Cunningham Julie M JM Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA.
Fridley BL Fridley Brooke L BL Department of Biostatistics, University of Kansas, Kansas City, Kansas, USA.
Winham SJ Winham Stacey J SJ Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Bandera EV Bandera Elisa V EV Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.
Poole EM Poole Elizabeth M EM Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Morgan TK Morgan Terry K TK Departments of Pathology and Obstetrics & Gynecology, OHSU, Portland, OR, USA.
Risch HA Risch Harvey A HA Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.
Goode EL Goode Ellen L EL Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA.
Schildkraut JM Schildkraut Joellen M JM Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA Cancer Control and Population Sciences, Duke Cancer Institute, Durham, North Carolina, USA.
Webb PM Webb Penelope M PM Population Health Department, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD 4006, Australia.
Pearce CL Pearce Celeste L CL Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Berchuck A Berchuck Andrew A Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA.
Pharoah PD Pharoah Paul D P PD The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK The Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Montgomery GW Montgomery Grant W GW Molecular Epidemiology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD 4006, Australia.
Zondervan KT Zondervan Krina T KT Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK Endometriosis CaRe Centre, Nuffield Dept of Obstetrics & Gynaecology, University of Oxford, UK.
Chenevix-Trench G Chenevix-Trench Georgia G Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD 4006, Australia.
Macgregor S Macgregor Stuart S Statistical Genetics, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD 4006, Australia stuart.macgregor@qimrberghofer.edu.au.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Anderson Carl A CA
Gordon Scott D SD
Guo Qun Q
Henders Anjali K AK
Lambert Ann A
Lee Sang Hong SH
Kraft Peter P
Kennedy Stephen H SH
Macgregor Stuart S
Martin Nicholas G NG
Missmer Stacey A SA
Montgomery Grant W GW
Morris Andrew P AP
Nyholt Dale R DR
Painter Jodie N JN
Roseman Fenella F
Treloar Susan A SA
Visscher Peter M PM
Wallace Leanne L
Zondervan Krina T KT
JOURNAL
VOLUME:
ISSUE:
TITLE: Human molecular genetics
ISOABBREVIATION: Hum. Mol. Genet.
YEAR: 2015
MONTH: Jul
DAY: 30
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1460-2083
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Hum Mol Genet
COUNTRY: England
ISSNLINKING: 0964-6906
NLMUNIQUEID: 9208958
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's