Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26226088
TITLE
Heritability of the Network Architecture of Intrinsic Brain Functional Connectivity.
ABSTRACT
NlmCategory: UNASSIGNED
The brain's functional network exhibits many features facilitating functional specialization, integration and robustness to attack. Using graph theory to characterize brain networks, studies demonstrate their small-world, modular, and "rich-club" properties, with deviations reported in many common neuropathological conditions. Here we estimate the heritability of five widely used graph theoretical metrics (Mean Clustering Coefficient (γ), Modularity (Q), Rich Club Coefficient (ϕnorm), Global Efficiency (λ), Small Worldness (σ)) over a range of connection densities (k=5-25%) in a large cohort of twins (N=592, 84 MZ and 89 DZ twin pairs, 246 single twins, age 23±2.5). We also considered the effects of global signal regression (GSR). We found the graph metrics were moderately influenced by genetic factors h(2)(γ=47-59%, Q=38-59%, ϕnorm=0-29%, λ =52-64%, σ=51-59%) at lower connection densities (≤15%), and when global signal regression was implemented heritability estimates decreased substantially h(2)(γ=0-26%, Q=0-28%, ϕnorm=0%, λ =23-30%, σ=0-27%). Distinct network features were phenotypically correlated (|r|=0.15-0.81) and γ, Q and λ were found to be influenced by overlapping genetic factors. Our findings suggest that these metrics may be potential endophenotypes for psychiatric disease and suitable for genetic association studies, but that genetic effects must be interpreted with respect to methodological choices.
Copyright 2015. Published by Elsevier Inc.
DATE PUBLISHED
2015 Jul 27
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/12/23
revised 2015/06/26
accepted 2015/07/17
entrez 2015/07/31 06:00
pubmed 2015/08/01 06:00
medline 2015/08/01 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Sinclair B Sinclair Benjamin B Centre for Advanced Imaging, University of Queensland, Brisbane, QLD 4072, Australia; School of Psychology, University of Queensland, Brisbane, QLD 4072, Australia; QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia. Electronic address: b.sinclair@uq.edu.au.
Hansell NK Hansell Narelle K NK QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia. Electronic address: Narelle.Hansell@qimrberghofer.edu.au.
Blokland GA Blokland Gabriëlla A M GA QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia. Electronic address: gabriellablokland@gmail.com.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia. Electronic address: Nick.Martin@qimrberghofer.edu.au.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Dept. of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90095, USA. Electronic address: pthomp@usc.edu.
Breakspear M Breakspear Michael M QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia. Electronic address: mjbreaks@gmail.com.
de Zubicaray GI de Zubicaray Greig I GI School of Psychology, University of Queensland, Brisbane, QLD 4072, Australia. Electronic address: Greig.dezubicaray@uq.edu.au.
Wright MJ Wright Margaret J MJ QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia. Electronic address: Margie.Wright@qimrberghofer.edu.au.
McMahon KL McMahon Katie L KL Centre for Advanced Imaging, University of Queensland, Brisbane, QLD 4072, Australia. Electronic address: Katie.McMahon@uq.edu.au.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: NeuroImage
ISOABBREVIATION: Neuroimage
YEAR: 2015
MONTH: Jul
DAY: 27
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1095-9572
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neuroimage
COUNTRY: United States
ISSNLINKING: 1053-8119
NLMUNIQUEID: 9215515
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
functional connectivity
genetics
graph theory
heritability
resting state
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's