Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25823843
TITLE
Quantitative genetics of disease traits.
ABSTRACT
John James authored two key papers on the theory of risk to relatives for binary disease traits and the relationship between parameters on the observed binary scale and an unobserved scale of liability (James Annals of Human Genetics, 1971; 35: 47; Reich, James and Morris Annals of Human Genetics, 1972; 36: 163). These two papers are John James' most cited papers (198 and 328 citations, November 2014). They have been influential in human genetics and have recently gained renewed popularity because of their relevance to the estimation of quantitative genetics parameters for disease traits using SNP data. In this review, we summarize the two early papers and put them into context. We show recent extensions of the theory for ascertained case-control data and review recent applications in human genetics.
2015 Blackwell Verlag GmbH.
DATE PUBLISHED
2015 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/11/20
accepted 2015/01/27
entrez 2015/04/01 06:00
pubmed 2015/04/01 06:00
medline 2015/09/22 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Wray NR Wray N R NR Queensland Brain Institute, The University of Queensland, Brisbane, Qld, Australia.
Visscher PM Visscher P M PM
INVESTIGATORS
JOURNAL
VOLUME: 132
ISSUE: 2
TITLE: Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie
ISOABBREVIATION: J. Anim. Breed. Genet.
YEAR: 2015
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1439-0388
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Anim Breed Genet
COUNTRY: Germany
ISSNLINKING: 0931-2668
NLMUNIQUEID: 100955807
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Historical Article
Journal Article
Research Support, Non-U.S. Gov't
Review
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Disease
liability
risk
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Animals
Disease genetics
Genetics history
Genomics history
History, 20th Century history
Humans history
Quantitative Trait Loci history
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's