Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25772435
TITLE
The relationship between cannabis involvement and suicidal thoughts and behaviors.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
In the present study, we examined the relationship between cannabis involvement and suicidal ideation (SI), plan and attempt, differentiating the latter into planned and unplanned attempt, taking into account other substance involvement and psychopathology.
METHODS NlmCategory: METHODS
We used two community-based twin samples from the Australian Twin Registry, including 9583 individuals (58.5% female, aged between 27 and 40). The Semi-Structured Assessment of the Genetics of Alcoholism (SSAGA) was used to assess cannabis involvement which was categorized into: (0) no cannabis use (reference category); (1) cannabis use only; (2) 1-2 cannabis use disorder symptoms; (3) 3 or more symptoms. Separate multinomial logistic regression analyses were conducted for SI and suicide attempt with or without a plan. Twin analyses examined the genetic overlap between cannabis involvement and SI.
RESULTS NlmCategory: RESULTS
All levels of cannabis involvement were related to SI, regardless of duration (odds ratios [ORs]=1.28-2.00, p<0.01). Cannabis use and endorsing ≥3 symptoms were associated with unplanned (SANP; ORs=1.95 and 2.51 respectively, p<0.05), but not planned suicide attempts (p>0.10). Associations persisted even after controlling for other psychiatric disorders and substance involvement. Overlapping genetic (rG=0.45) and environmental (rE=0.21) factors were responsible for the covariance between cannabis involvement and SI.
CONCLUSIONS NlmCategory: CONCLUSIONS
Cannabis involvement is associated, albeit modestly, with SI and unplanned suicide attempts. Such attempts are difficult to prevent and their association with cannabis use and cannabis use disorder symptoms requires further study, including in different samples and with additional attention to confounders.
Copyright 2015. Published by Elsevier Ireland Ltd.
DATE PUBLISHED
2015 May 1
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/09/22
revised 2015/02/05
accepted 2015/02/14
aheadofprint 2015/02/26
entrez 2015/03/17 06:00
pubmed 2015/03/17 06:00
medline 2015/10/24 06:00
pmc-release 2016/05/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Delforterie MJ Delforterie M J MJ VU University, Department of Developmental Psychology and EMGO Institute for Health and Care Research, Amsterdam, The Netherlands.
Lynskey MT Lynskey M T MT Addictions Department, Institute of Psychiatry, King's College London, United Kingdom.
Huizink AC Huizink A C AC VU University, Department of Developmental Psychology and EMGO Institute for Health and Care Research, Amsterdam, The Netherlands.
Creemers HE Creemers H E HE Research Institute of Child Development and Education, University of Amsterdam, Amsterdam, The Netherlands.
Grant JD Grant J D JD Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Few LR Few L R LR Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Glowinski AL Glowinski A L AL Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Statham DJ Statham D J DJ School of Social Sciences, University of the Sunshine Coast, Queensland, Australia.
Trull TJ Trull T J TJ University of Missouri, Department of Psychological Sciences, Columbia, MO, USA.
Bucholz KK Bucholz K K KK Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Madden PA Madden P A F PA Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Martin NG Martin N G NG QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Heath AC Heath A C AC Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Agrawal A Agrawal A A Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: arpana@wustl.edu.
INVESTIGATORS
JOURNAL
VOLUME: 150
ISSUE:
TITLE: Drug and alcohol dependence
ISOABBREVIATION: Drug Alcohol Depend
YEAR: 2015
MONTH: May
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1879-0046
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Drug Alcohol Depend
COUNTRY: Ireland
ISSNLINKING: 0376-8716
NLMUNIQUEID: 7513587
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Am J Epidemiol. 2000 Apr 15;151(8):781-9 10965975
Cites Drug Alcohol Rev. 2010 May;29(3):318-30 20565525
Cites Br J Psychiatry. 2001 Feb;178:116-22 11157424
Cites Arch Gen Psychiatry. 2002 Feb;59(2):139-45 11825135
Cites Psychol Med. 2002 Feb;32(2):195-207 11871371
Cites Suicide Life Threat Behav. 2001;32(1 Suppl):49-59 11924695
Cites Neuropsychopharmacology. 2002 Apr;26(4):479-88 11927172
Cites Addiction. 2002 Sep;97(9):1123-35 12199828
Cites Twin Res. 2003 Apr;6(2):106-18 12723997
Cites Am J Psychiatry. 2004 Mar;161(3):562-3 14992984
Cites Suicide Life Threat Behav. 2004 Summer;34(2):89-98 15191266
Cites Arch Gen Psychiatry. 2004 Oct;61(10):1026-32 15466676
Cites Arch Gen Psychiatry. 1972 Sep;27(3):349-53 5051623
Cites Am J Psychiatry. 1985 Nov;142(11):1259-64 3904487
Cites J Stud Alcohol. 1994 Mar;55(2):149-58 8189735
Cites Suicide Life Threat Behav. 1994 Summer;24(2):174-83 8053011
Cites Am J Med Genet. 1995 Dec 18;60(6):588-91 8825903
Cites Br J Psychiatry. 1997 Mar;170:205-28 9229027
Cites Harv Rev Psychiatry. 1997 Jan-Feb;4(5):231-44 9385000
Cites Psychol Med. 1998 Jul;28(4):839-55 9723140
Cites Drug Alcohol Depend. 2004 Dec 7;76 Suppl:S53-67 15555817
Cites Br J Psychiatry. 2005 Jan;186:60-6 15630125
Cites Drug Alcohol Depend. 2005 Jul;79(1):11-22 15943940
Cites J Abnorm Psychol. 2006 Aug;115(3):616-23 16866602
Cites Lancet. 2007 Jul 28;370(9584):319-28 17662880
Cites J Stud Alcohol Drugs. 2007 Sep;68(5):654-62 17690798
Cites J Affect Disord. 2010 Dec;127(1-3):287-94 20471691
Cites Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15;35(7):1575-85 21111017
Cites Twin Res Hum Genet. 2012 Oct;15(5):631-41 22874079
Cites J Health Econ. 2013 May;32(3):524-37 23518573
Cites JAMA Psychiatry. 2014 Jun;71(6):699-705 24760386
Cites NCHS Data Brief. 2014 Oct;(168):1-8 25296181
Cites Br J Psychiatry. 2008 Feb;192(2):98-105 18245022
Cites Acta Psychiatr Scand. 2008 Nov;118(5):395-403 18798834
Cites Epidemiol Rev. 2008;30:133-54 18653727
Cites J Stud Alcohol Drugs. 2009 Jul;70(4):623-7 19515304
Cites Br J Psychiatry. 2009 Dec;195(6):492-7 19949196
Cites Addiction. 2010 Mar;105(3):417-30 20402985
Cites J Consult Clin Psychol. 2000 Oct;68(5):909-16 11068977
GRANTS
GRANTID AGENCY COUNTRY
AA07728 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA13221 NIAAA NIH HHS United States
DA12854 NIDA NIH HHS United States
DA18267 NIDA NIH HHS United States
DA23668 NIDA NIH HHS United States
DA32573 NIDA NIH HHS United States
F32 AA023693 NIAAA NIH HHS United States
K02 DA032573 NIDA NIH HHS United States
K21DA00272 NIDA NIH HHS United States
P60 AA011998 NIAAA NIH HHS United States
R01 AA007728 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 DA018267 NIDA NIH HHS United States
R01 DA023668 NIDA NIH HHS United States
T32DA007313 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Cannabis use
Cannabis use disorder symptoms
Suicidal thoughts and behaviors
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Australia
Female
Humans
Male
Marijuana Abuse psychology
Marijuana Smoking psychology
Suicidal Ideation psychology
Suicide psychology
Suicide, Attempted psychology
Twins psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS694618 [Available on 05/01/16] NLM
PMC4460828 [Available on 05/01/16] NLM