Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25747917
TITLE
Heritability of fractional anisotropy in human white matter: a comparison of Human Connectome Project and ENIGMA-DTI data.
ABSTRACT
The degree to which genetic factors influence brain connectivity is beginning to be understood. Large-scale efforts are underway to map the profile of genetic effects in various brain regions. The NIH-funded Human Connectome Project (HCP) is providing data valuable for analyzing the degree of genetic influence underlying brain connectivity revealed by state-of-the-art neuroimaging methods. We calculated the heritability of the fractional anisotropy (FA) measure derived from diffusion tensor imaging (DTI) reconstruction in 481 HCP subjects (194/287 M/F) consisting of 57/60 pairs of mono- and dizygotic twins, and 246 siblings. FA measurements were derived using (Enhancing NeuroImaging Genetics through Meta-Analysis) ENIGMA DTI protocols and heritability estimates were calculated using the SOLAR-Eclipse imaging genetic analysis package. We compared heritability estimates derived from HCP data to those publicly available through the ENIGMA-DTI consortium, which were pooled together from five-family based studies across the US, Europe, and Australia. FA measurements from the HCP cohort for eleven major white matter tracts were highly heritable (h(2)=0.53-0.90, p<10(-5)), and were significantly correlated with the joint-analytical estimates from the ENIGMA cohort on the tract and voxel-wise levels. The similarity in regional heritability suggests that the additive genetic contribution to white matter microstructure is consistent across populations and imaging acquisition parameters. It also suggests that the overarching genetic influence provides an opportunity to define a common genetic search space for future gene-discovery studies. Uniquely, the measurements of additive genetic contribution performed in this study can be repeated using online genetic analysis tools provided by the HCP ConnectomeDB web application.
Copyright 2015 Elsevier Inc. All rights reserved.
DATE PUBLISHED
2015 May 1
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/10/23
revised 2015/01/10
accepted 2015/02/23
aheadofprint 2015/03/04
entrez 2015/03/10 06:00
pubmed 2015/03/10 06:00
medline 2016/04/08 06:00
pmc-release 2016/05/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Kochunov P Kochunov Peter P Maryland Psychiatric Research Center, University of MD School of Medicine, Baltimore USA. Electronic address: pkochunov@mprc.umaryland.edu.
Jahanshad N Jahanshad Neda N Imaging Genetics Center, Institute for Neuroimaging and Informatics, Department of Neurology Keck School of Medicine, University of Southern CA, Marina del Rey, USA.
Marcus D Marcus Daniel D Department of Radiology, Washington University School of Medicine, St. Louis, USA.
Winkler A Winkler Anderson A FMRIB Centre, Oxford University, Oxford, UK.
Sprooten E Sprooten Emma E Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, USA.
Nichols TE Nichols Thomas E TE Department of Statistics, University of Warwick, Warwick, UK.
Wright SN Wright Susan N SN Maryland Psychiatric Research Center, University of MD School of Medicine, Baltimore USA.
Hong LE Hong L Elliot LE Maryland Psychiatric Research Center, University of MD School of Medicine, Baltimore USA.
Patel B Patel Binish B Maryland Psychiatric Research Center, University of MD School of Medicine, Baltimore USA.
Behrens T Behrens Timothy T FMRIB Centre, Oxford University, Oxford, UK.
Jbabdi S Jbabdi Saad S FMRIB Centre, Oxford University, Oxford, UK.
Andersson J Andersson Jesper J FMRIB Centre, Oxford University, Oxford, UK.
Lenglet C Lenglet Christophe C Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Yacoub E Yacoub Essa E Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Moeller S Moeller Steen S Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Auerbach E Auerbach Eddie E Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Ugurbil K Ugurbil Kamil K Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Sotiropoulos SN Sotiropoulos Stamatios N SN FMRIB Centre, Oxford University, Oxford, UK.
Brouwer RM Brouwer Rachel M RM University Medical Center Utrecht, Utrecht, The Netherlands.
Landman B Landman Bennett B Vanderbilt University, Nashville, TN, USA.
Lemaitre H Lemaitre Hervé H INSERM-CEA-Faculté de Médecine Paris-Sud, Orsay France.
den Braber A den Braber Anouk A VU University, Amsterdam, The Netherlands.
Zwiers MP Zwiers Marcel P MP Radboud University, Nijmegen, The Netherlands.
Ritchie S Ritchie Stuart S University of Edinburgh, Edinburgh, UK.
van Hulzen K van Hulzen Kimm K Radboud University, Nijmegen, The Netherlands.
Almasy L Almasy Laura L Texas Biomedical Research Institute, San Antonio, TX, USA.
Curran J Curran Joanne J Texas Biomedical Research Institute, San Antonio, TX, USA.
deZubicaray GI deZubicaray Greig I GI University of Queensland, Brisbane, Australia.
Duggirala R Duggirala Ravi R Texas Biomedical Research Institute, San Antonio, TX, USA.
Fox P Fox Peter P University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
Martin NG Martin Nicholas G NG QIMR Berghofer, Brisbane, Australia.
McMahon KL McMahon Katie L KL University of Queensland, Brisbane, Australia.
Mitchell B Mitchell Braxton B University of Maryland, Baltimore, MD, USA.
Olvera RL Olvera Rene L RL University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
Peterson C Peterson Charles C Texas Biomedical Research Institute, San Antonio, TX, USA.
Starr J Starr John J University of Edinburgh, Edinburgh, UK.
Sussmann J Sussmann Jessika J University of Edinburgh, Edinburgh, UK.
Wardlaw J Wardlaw Joanna J University of Edinburgh, Edinburgh, UK.
Wright M Wright Margie M QIMR Berghofer, Brisbane, Australia.
Boomsma DI Boomsma Dorret I DI VU University, Amsterdam, The Netherlands.
Kahn R Kahn Rene R University Medical Center Utrecht, Utrecht, The Netherlands.
de Geus EJ de Geus Eco J C EJ VU University, Amsterdam, The Netherlands.
Williamson DE Williamson Douglas E DE University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
Hariri A Hariri Ahmad A Duke University, Durham, NC, USA.
van 't Ent D van 't Ent Dennis D VU University, Amsterdam, The Netherlands.
Bastin ME Bastin Mark E ME University of Edinburgh, Edinburgh, UK.
McIntosh A McIntosh Andrew A University of Edinburgh, Edinburgh, UK.
Deary IJ Deary Ian J IJ University of Edinburgh, Edinburgh, UK.
Hulshoff Pol HE Hulshoff Pol Hilleke E HE University Medical Center Utrecht, Utrecht, The Netherlands.
Blangero J Blangero John J Texas Biomedical Research Institute, San Antonio, TX, USA.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Institute for Neuroimaging and Informatics, Department of Neurology Keck School of Medicine, University of Southern CA, Marina del Rey, USA.
Glahn DC Glahn David C DC Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, USA.
Van Essen DC Van Essen David C DC Anatomy & Neurobiology Department, Washington University in St. Louis, St. Louis, USA.
INVESTIGATORS
JOURNAL
VOLUME: 111
ISSUE:
TITLE: NeuroImage
ISOABBREVIATION: Neuroimage
YEAR: 2015
MONTH: May
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1095-9572
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neuroimage
COUNTRY: United States
ISSNLINKING: 1053-8119
NLMUNIQUEID: 9215515
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
087727/Z/08/Z Wellcome Trust United Kingdom
100309 Wellcome Trust United Kingdom
104036 Wellcome Trust United Kingdom
EB007813 NIBIB NIH HHS United States
G0700704 Medical Research Council United Kingdom
MH0708143 NIMH NIH HHS United States
MH078111 NIMH NIH HHS United States
MH083824 NIMH NIH HHS United States
MH59490 NIMH NIH HHS United States
MR/K026992/1 Medical Research Council United Kingdom
P41 EB015922 NIBIB NIH HHS United States
R01 AG040060 NIA NIH HHS United States
R01 DA033369 NIDA NIH HHS United States
R01 EB008281 NIBIB NIH HHS United States
R01 EB008432 NIBIB NIH HHS United States
R01 EB015611 NIBIB NIH HHS United States
R01 EB015611 NIBIB NIH HHS United States
RF1 AG041915 NIA NIH HHS United States
U54 EB020403 NIBIB NIH HHS United States
U54 EB020403 NIBIB NIH HHS United States
U54 MH091657 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Anisotropy
Cohort Studies
Connectome methods
Diffusion Tensor Imaging methods
Female methods
Genetic Phenomena methods
Humans methods
Male methods
Nerve Net anatomy & histology
Registries anatomy & histology
White Matter anatomy & histology
Young Adult anatomy & histology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS669356 [Available on 05/01/16] NLM
PMC4387079 [Available on 05/01/16] NLM