Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25712083
TITLE
Intelligence: shared genetic basis between Mendelian disorders and a polygenic trait.
ABSTRACT
NlmCategory: UNASSIGNED
Multiple inquiries into the genetic etiology of human traits indicated an overlap between genes underlying monogenic disorders (eg, skeletal growth defects) and those affecting continuous variability of related quantitative traits (eg, height). Extending the idea of a shared genetic basis between a Mendelian disorder and a classic polygenic trait, we performed an association study to examine the effect of 43 genes implicated in autosomal recessive cognitive disorders on intelligence in an unselected Dutch population (N=1316). Using both single-nucleotide polymorphism (SNP)- and gene-based association testing, we detected an association between intelligence and the genes of interest, with genes ELP2, TMEM135, PRMT10, and RGS7 showing the strongest associations. This is a demonstration of the relevance of genes implicated in monogenic disorders of intelligence to normal-range intelligence, and a corroboration of the utility of employing knowledge on monogenic disorders in identifying the genetic variability underlying complex traits.European Journal of Human Genetics advance online publication, 25 February 2015; doi:10.1038/ejhg.2015.3.
DATE PUBLISHED
2015 Feb 25
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/02/12
revised 2014/12/16
accepted 2014/12/25
entrez 2015/02/26 06:00
pubmed 2015/02/26 06:00
medline 2015/02/26 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Franić S Franić Sanja S Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Groen-Blokhuis MM Groen-Blokhuis Maria M MM Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Dolan CV Dolan Conor V CV 1] Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands [2] Department of Psychological Methods, University of Amsterdam, Amsterdam, The Netherlands.
Kattenberg MV Kattenberg Mathijs V MV Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Pool R Pool René R Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Xiao X Xiao Xiangjun X Division of OVP, Cancer Prevention and Population Sciences, Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Scheet PA Scheet Paul A PA Division of OVP, Cancer Prevention and Population Sciences, Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ehli EA Ehli Erik A EA Avera Institute for Human Genetics, Avera McKennan Hospital, University Health Center, Sioux Falls, SD, USA.
Davies GE Davies Gareth E GE Avera Institute for Human Genetics, Avera McKennan Hospital, University Health Center, Sioux Falls, SD, USA.
van der Sluis S van der Sluis Sophie S Section Functional Genomics, Department of Clinical Genetics, VU Medical Center Amsterdam, Amsterdam, The Netherlands.
Abdellaoui A Abdellaoui Abdel A Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Hansell NK Hansell Narelle K NK Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, Queensland Institute of Medical Research, Brisbane, Australia.
Martin NG Martin Nicholas G NG Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, Queensland Institute of Medical Research, Brisbane, Australia.
Hudziak JJ Hudziak James J JJ Department of Psychiatry and Medicine, University of Vermont, Burlington, VT, USA.
van Beijsterveldt CE van Beijsterveldt Catherina E M CE Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Swagerman SC Swagerman Suzanne C SC Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Hulshoff Pol HE Hulshoff Pol Hilleke E HE Neuroimaging Research Group, University Medical Center Utrecht, Utrecht, The Netherlands.
de Geus EJ de Geus Eco J C EJ Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Bartels M Bartels Meike M Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Ropers HH Ropers H Hilger HH Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Hottenga JJ Hottenga Jouke-Jan JJ Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: European journal of human genetics : EJHG
ISOABBREVIATION: Eur. J. Hum. Genet.
YEAR: 2015
MONTH: Feb
DAY: 25
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5438
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Eur J Hum Genet
COUNTRY: England
ISSNLINKING: 1018-4813
NLMUNIQUEID: 9302235
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
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