Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25694186
TITLE
Retinal microvessels reflect familial vulnerability to psychotic symptoms: A comparison of twins discordant for psychotic symptoms and controls.
ABSTRACT
Mounting evidence suggests that individuals with schizophrenia have an underlying vulnerability to cardiovascular disease, and a recent study suggested that this vulnerability might be reflected in the retinal microvasculature. The purpose of this study was to test the hypothesis that the retinal microvessels reflect familial vulnerability to psychotic symptoms. Participants were 531 adolescent and young adult twins who took part in the Brisbane Longitudinal Twin Study and the Twins Eye Study in Tasmania. The twins had photographs taken of their retina when they were adolescents or young adults (M age=20.6 years), and retinal vessel diameter was assessed using computer software. The twins completed an assessment of psychosis symptoms approximately six years later. We compared retinal venular diameters of individuals with one or more symptoms of psychosis (n=45), their unaffected co-twins (n=24), and controls (n=462). Individuals with one or more symptoms of psychosis had wider venules (standardized mean=0.29) than controls (standardized mean=-0.04; p=.03), and unaffected co-twins had venular diameters that were intermediate (standardized mean=0.13) between the two groups, suggesting that wide venules may represent a proxy marker of familial vulnerability to psychosis symptoms. Consistent with previous work, there were no differences in arteriolar diameter between individuals with and without symptoms of psychosis. Findings suggest that wide retinal venules may serve as a proxy marker of familial liability to psychosis symptoms. The pathophysiological mechanisms linking psychosis and cardiovascular disease may be operative from early in life, possibly at the level of the microvasculature.
Copyright 2015 Elsevier B.V. All rights reserved.
DATE PUBLISHED
2015 May
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/11/04
revised 2015/01/26
accepted 2015/01/29
aheadofprint 2015/02/16
entrez 2015/02/20 06:00
pubmed 2015/02/20 06:00
medline 2016/03/24 06:00
pmc-release 2016/05/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Meier MH Meier Madeline H MH Department of Psychology, Arizona State University, Tempe, AZ, USA. Electronic address: madeline.meier@asu.edu.
Gillespie NA Gillespie Nathan A NA Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA; QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Hansell NK Hansell Narelle K NK QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Hewitt AW Hewitt Alex W AW Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia; Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia.
Hickie IB Hickie Ian B IB Brain and Mind Research Institute, University of Sydney, Sydney, Australia.
Lu Y Lu Yi Y QIMR Berghofer Medical Research Institute, Brisbane, Australia.
McGrath J McGrath John J Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia; Queensland Brain Institute, University of Queensland, St Lucia, Australia.
MacGregor S MacGregor Stuart S QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Medland SE Medland Sarah E SE QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Sun C Sun Cong C Environmental and Genetic Epidemiology Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.
Wong TY Wong Tien Y TY Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore.
Wright MJ Wright Margaret J MJ QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Zhu G Zhu Gu G QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Mackey DA Mackey David A DA Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia; Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 164
ISSUE: 1-3
TITLE: Schizophrenia research
ISOABBREVIATION: Schizophr. Res.
YEAR: 2015
MONTH: May
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1573-2509
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Schizophr Res
COUNTRY: Netherlands
ISSNLINKING:
NLMUNIQUEID: 8804207
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
DA023549 NIDA NIH HHS United States
R00 DA023549 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Psychosis
Retinal vessel diameter
Twin
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Diagnosis, Computer-Assisted
Family Health
Female
Humans
Longitudinal Studies
Male
Psychiatric Status Rating Scales
Psychotic Disorders pathology
Retinal Vessels pathology
Young Adult pathology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS662087 [Available on 05/01/16] NLM
PMC4409503 [Available on 05/01/16] NLM