Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25599223
TITLE
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways.
ABSTRACT
Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these signals indicate. We sought to identify biological pathways in GWAS data from over 60,000 participants from the Psychiatric Genomics Consortium. We developed an analysis framework to rank pathways that requires only summary statistics. We combined this score across disorders to find common pathways across three adult psychiatric disorders: schizophrenia, major depression and bipolar disorder. Histone methylation processes showed the strongest association, and we also found statistically significant evidence for associations with multiple immune and neuronal signaling pathways and with the postsynaptic density. Our study indicates that risk variants for psychiatric disorders aggregate in particular biological pathways and that these pathways are frequently shared between disorders. Our results confirm known mechanisms and suggest several novel insights into the etiology of psychiatric disorders.
DATE PUBLISHED
2015 Feb
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/05/31
accepted 2014/12/10
aheadofprint 2015/01/19
entrez 2015/01/20 06:00
pubmed 2015/01/20 06:00
medline 2015/01/20 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium
International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)
International Inflammatory Bowel Disease Genetics Consortium IIBDGC
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Devlin Bernie B
Kelsoe John R JR
Sklar Pamela P
Daly Mark J MJ
O'Donovan Michael C MC
Craddock Nicholas N
Kendler Kenneth S KS
A Weiss Lauren L
Wray Naomi R NR
Zhao Zhaoming Z
Geschwind Daniel H DH
Sullivan Patrick F PF
Smoller Jordan W JW
Holmans Peter A PA
Breen Gerome G
JOURNAL
VOLUME: 18
ISSUE: 2
TITLE: Nature neuroscience
ISOABBREVIATION: Nat. Neurosci.
YEAR: 2015
MONTH: Feb
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1726
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Neurosci
COUNTRY: United States
ISSNLINKING: 1097-6256
NLMUNIQUEID: 9809671
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
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