Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25562672
TITLE
Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
To test common genetic variants for association with seasonality (seasonal changes in mood and behavior) and to investigate whether there are shared genetic risk factors between psychiatric disorders and seasonality.
METHOD NlmCategory: METHODS
Genome-wide association studies (GWASs) were conducted in Australian (between 1988 and 1990 and between 2010 and 2013) and Amish (between May 2010 and December 2011) samples in whom the Seasonal Pattern Assessment Questionnaire (SPAQ) had been administered, and the results were meta-analyzed in a total sample of 4,156 individuals. Genetic risk scores based on results from prior large GWAS studies of bipolar disorder, major depressive disorder (MDD), and schizophrenia were calculated to test for overlap in risk between psychiatric disorders and seasonality.
RESULTS NlmCategory: RESULTS
The most significant association was with rs11825064 (P = 1.7 × 10⁻⁶, β = 0.64, standard error = 0.13), an intergenic single nucleotide polymorphism (SNP) found on chromosome 11. The evidence for overlap in risk factors was strongest for schizophrenia and seasonality, with the schizophrenia genetic profile scores explaining 3% of the variance in log-transformed global seasonality scores. Bipolar disorder genetic profile scores were also associated with seasonality, although at much weaker levels (minimum P value = 3.4 × 10⁻³), and no evidence for overlap in risk was detected between MDD and seasonality.
CONCLUSIONS NlmCategory: CONCLUSIONS
Common SNPs of large effect most likely do not exist for seasonality in the populations examined. As expected, there were overlapping genetic risk factors for bipolar disorder (but not MDD) with seasonality. Unexpectedly, the risk for schizophrenia and seasonality had the largest overlap, an unprecedented finding that requires replication in other populations and has potential clinical implications considering overlapping cognitive deficits in seasonal affective disorders and schizophrenia.
Copyright 2015 Physicians Postgraduate Press, Inc.
DATE PUBLISHED
2015 Feb
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/01/02
accepted 2014/08/29
entrez 2015/01/07 06:00
pubmed 2015/01/07 06:00
medline 2015/04/29 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Byrne EM Byrne Enda M EM The University of Queensland, Queensland Brain Institute, Upland Rd, St Lucia, QLD 4072, Brisbane, Australia enda.byrne@uq.edu.au.
Psychiatric Genetics Consortium Major Depressive Disorder Working Group
Raheja UK Raheja Uttam K UK
Stephens SH Stephens Sarah H SH
Heath AC Heath Andrew C AC
Madden PA Madden Pamela A F PA
Vaswani D Vaswani Dipika D
Nijjar GV Nijjar Gagan V GV
Ryan KA Ryan Kathleen A KA
Youssufi H Youssufi Hassaan H
Gehrman PR Gehrman Philip R PR
Shuldiner AR Shuldiner Alan R AR
Martin NG Martin Nicholas G NG
Montgomery GW Montgomery Grant W GW
Wray NR Wray Naomi R NR
Nelson EC Nelson Elliot C EC
Mitchell BD Mitchell Braxton D BD
Postolache TT Postolache Teodor T TT
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Ripke Stephan S
Wray Naomi R NR
Lewis Cathryn M CM
Hamilton Steven P SP
Weissman Myrna M MM
Breen Gerome G
Byrne Enda M EM
Blackwood Douglas H R DH
Boomsma Dorret I DI
Cichon Sven S
Heath Andrew C AC
Holsboer Florian F
Lucae Susanne S
Madden Pamela A F PA
Martin Nicholas G NG
McGuffin Peter P
Muglia Pierandrea P
Noethen Markus M MM
Penninx Brenda P BP
Pergadia Michele L ML
Potash James B JB
Rietschel Marcella M
Lin Danyu D
Müller-Myhsok Bertram B
Shi Jianxin J
Steinberg Stacy S
Grabe Hans J HJ
Lichtenstein Paul P
Magnusson Patrik P
Perlis Roy H RH
Preisig Martin M
Smoller Jordan W JW
Stefansson Kari K
Uher Rudolf R
Kutalik Zoltan Z
Tansey Katherine E KE
Teumer Alexander A
Viktorin Alexander A
Barnes Michael R MR
Bettecken Thomas T
Binder Elisabeth B EB
Breuer René R
Castro Victor M VM
Churchill Susanne E SE
Coryell William H WH
Craddock Nick N
Craig Ian W IW
Czamara Darina D
De Geus Eco J EJ
Degenhardt Franziska F
Farmer Anne E AE
Fava Maurizio M
Frank Josef J
Gainer Vivian S VS
Gallagher Patience J PJ
Gordon Scott D SD
Goryachev Sergey S
Gross Magdalena M
Guipponi Michel M
Henders Anjali K AK
Herms Stefan S
Hickie Ian B IB
Hoefels Susanne S
Hoogendijk Witte W
Hottenga Jouke Jan JJ
Iosifescu Dan V DV
Ising Marcus M
Jones Ian I
Jones Lisa L
Jung-Ying Tzeng T
Knowles James A JA
Kohane Isaac S IS
Kohli Martin A MA
Korszun Ania A
Landen Mikael M
Lawson William B WB
Lewis Glyn G
MacIntyre Donald D
Maier Wolfgang W
Mattheisen Manuel M
McGrath Patrick J PJ
McIntosh Andrew A
McLean Alan A
Middeldorp Christel M CM
Middleton Lefkos L
Montgomery Grant M GM
Murphy Shawn N SN
Nauck Matthias M
Nolen Willem A WA
Nyholt Dale R DR
O'Donovan Michael M
Oskarsson Högni H
Pedersen Nancy N
Scheftner William A WA
Schulz Andrea A
Schulze Thomas G TG
Shyn Stanley I SI
Sigurdsson Engilbert E
Slager Susan L SL
Smit Johannes H JH
Stefansson Hreinn H
Steffens Michael M
Thorgeirsson Thorgeir T
Tozzi Federica F
Treutlein Jens J
Uhr Manfred M
van den Oord Edwin J C G EJ
Van Grootheest Gerard G
Völzke Henry H
Weilburg Jeffrey B JB
Willemsen Gonneke G
Zitman Frans G FG
Neale Benjamin B
Daly Mark M
Levinson Douglas F DF
Sullivan Patrick F PF
JOURNAL
VOLUME: 76
ISSUE: 2
TITLE: The Journal of clinical psychiatry
ISOABBREVIATION: J Clin Psychiatry
YEAR: 2015
MONTH: Feb
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1555-2101
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Clin Psychiatry
COUNTRY: United States
ISSNLINKING: 0160-6689
NLMUNIQUEID: 7801243
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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CommentIn J Clin Psychiatry. 2015 Feb;76(2):e214-5 25742209
GRANTS
GRANTID AGENCY COUNTRY
K18 MH093940 NIMH NIH HHS United States
P30 DK072488 NIDDK NIH HHS United States
P60 AA011998 NIAAA NIH HHS United States
R25 MH060482 NIMH NIH HHS United States
U01 MH085520 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Alcoholism psychology
Amish psychology
Bipolar Disorder psychology
Depressive Disorder, Major psychology
Diseases in Twins psychology
Female psychology
Genotype psychology
Humans psychology
Life Change Events psychology
Male psychology
Middle Aged psychology
Multifactorial Inheritance genetics
Psychiatric Status Rating Scales genetics
Queensland genetics
Schizophrenia genetics
Schizophrenic Psychology genetics
United States genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS708858 NLM
PMC4527536 NLM