Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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25469926
TITLE
Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study.
ABSTRACT
Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P=1.1 × 10(-9)). This finding was replicated in an African-American sample of 4771 individuals (lowest P=9.3 × 10(-4)). The strongest combined association was at rs1823125 (P=1.5 × 10(-10), minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease.
DATE PUBLISHED
2015 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2013/11/11
revised 2014/09/01
accepted 2014/09/04
aheadofprint 2014/12/02
entrez 2014/12/04 06:00
pmc-release 2016/04/01 00:00
pubmed 2014/12/04 06:00
medline 2014/12/04 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Gottlieb DJ Gottlieb D J DJ The NHLBI's Framingham Heart Study, Framingham, MA, USA.
Hek K Hek K K Epidemiological and Social Psychiatric Research Institute, Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands.
Chen TH Chen T-H TH Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Watson NF Watson N F NF UW Medicine Sleep Center, University of Washington, Seattle, WA, USA.
Eiriksdottir G Eiriksdottir G G Icelandic Heart Association, Kópavogur, Iceland.
Byrne EM Byrne E M EM Queensland Institute of Medical Research, Brisbane, QLD, Australia.
Cornelis M Cornelis M M Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Warby SC Warby S C SC Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, CA, USA.
Bandinelli S Bandinelli S S Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
Cherkas L Cherkas L L Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Evans DS Evans D S DS California Pacific Medical Center Research Institute, San Francisco, CA, USA.
Grabe HJ Grabe H J HJ Department of Psychiatry and Psychotherapy, HELIOS-Hospital Stralsund, University Medicine Greifswald, Greifswald, Germany.
Lahti J Lahti J J Folkhalsan Research Centre, Helsinki, Finland.
Li M Li M M Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Lehtimäki T Lehtimäki T T Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland.
Lumley T Lumley T T Department of Statistics, University of Auckland, Auckland, New Zealand.
Marciante KD Marciante K D KD Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Pérusse L Pérusse L L Institute of Nutrition and Functional Foods, Laval University, Quebec, Canada.
Psaty BM Psaty B M BM Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.
Robbins J Robbins J J Department of Internal Medicine, University of California Davis, Sacramento, CA, USA.
Tranah GJ Tranah G J GJ California Pacific Medical Center Research Institute, San Francisco, CA, USA.
Vink JM Vink J M JM Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Wilk JB Wilk J B JB Precision Medicine, Cambridge, MA, USA.
Stafford JM Stafford J M JM Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Bellis C Bellis C C Texas Biomedical Research Institute, San Antonio, TX, USA.
Biffar R Biffar R R Department of Prosthodontics, Gerodontology and Dental Materials, Center of Oral Health, University Medicine Greifswald, Greifswald, Germany.
Bouchard C Bouchard C C Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Cade B Cade B B Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Curhan GC Curhan G C GC Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Eriksson JG Eriksson J G JG Vasa Central Hospital, Vasa, Finland.
Ewert R Ewert R R Department of Internal Medicine B-Cardiology, Pulmonary Medicine, Infectious Diseases and Intensive Care Medicine, University Medicine Greifswald, Greifswald, Germany.
Ferrucci L Ferrucci L L Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Fülöp T Fülöp T T Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Gehrman PR Gehrman P R PR Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Goodloe R Goodloe R R Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Harris TB Harris T B TB Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA.
Heath AC Heath A C AC Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Hernandez D Hernandez D D Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
Hofman A Hofman A A Epidemiological and Social Psychiatric Research Institute, Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands.
Hottenga JJ Hottenga J-J JJ Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Hunter DJ Hunter D J DJ Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Jensen MK Jensen M K MK Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
Johnson AD Johnson A D AD NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, Framingham, MA, USA.
Kähönen M Kähönen M M Department of Clinical Physiology, Tampere University Hospital and School of Medicine University of Tampere, Tampere, Finland.
Kao L Kao L L Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Kraft P Kraft P P Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Larkin EK Larkin E K EK Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Lauderdale DS Lauderdale D S DS Department of Health Studies, University of Chicago, Chicago, IL, USA.
Luik AI Luik A I AI Epidemiological and Social Psychiatric Research Institute, Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands.
Medici M Medici M M Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Montgomery GW Montgomery G W GW Queensland Institute of Medical Research, Brisbane, QLD, Australia.
Palotie A Palotie A A Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Patel SR Patel S R SR Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Pistis G Pistis G G Dipartimento di Scienze Biomediche, Universita' di Sassari, Sassari, Italy.
Porcu E Porcu E E Dipartimento di Scienze Biomediche, Universita' di Sassari, Sassari, Italy.
Quaye L Quaye L L Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Raitakari O Raitakari O O Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, and Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Redline S Redline S S Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Rimm EB Rimm E B EB Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Rotter JI Rotter J I JI Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.
Smith AV Smith A V AV University of Iceland, Reykjavik, Iceland.
Spector TD Spector T D TD Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Teumer A Teumer A A Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Uitterlinden AG Uitterlinden A G AG Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.
Vohl MC Vohl M-C MC Department of Food Science and Nutrition, Laval University, Quebec, Canada.
Widen E Widen E E Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Willemsen G Willemsen G G Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Young T Young T T Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Zhang X Zhang X X NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, Framingham, MA, USA.
Liu Y Liu Y Y Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Blangero J Blangero J J Texas Biomedical Research Institute, San Antonio, TX, USA.
Boomsma DI Boomsma D I DI Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Gudnason V Gudnason V V University of Iceland, Reykjavik, Iceland.
Hu F Hu F F Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Mangino M Mangino M M Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Martin NG Martin N G NG Queensland Institute of Medical Research, Brisbane, QLD, Australia.
O'Connor GT O'Connor G T GT The NHLBI's Framingham Heart Study, Framingham, MA, USA.
Stone KL Stone K L KL California Pacific Medical Center Research Institute, San Francisco, CA, USA.
Tanaka T Tanaka T T Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Viikari J Viikari J J Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Gharib SA Gharib S A SA Department of Medicine, University of Washington, Seattle, WA, USA.
Punjabi NM Punjabi N M NM Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Räikkönen K Räikkönen K K Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
Völzke H Völzke H H Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Mignot E Mignot E E Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, CA, USA.
Tiemeier H Tiemeier H H Department of Child and Adolescent Psychiatry, Erasmus MC, Rotterdam, The Netherlands.
INVESTIGATORS
JOURNAL
VOLUME: 20
ISSUE: 10
TITLE: Molecular psychiatry
ISOABBREVIATION: Mol. Psychiatry
YEAR: 2015
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5578
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Mol Psychiatry
COUNTRY: England
ISSNLINKING: 1359-4184
NLMUNIQUEID: 9607835
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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NIHMS682620 [Available on 04/01/16] NLM
PMC4430294 [Available on 04/01/16] NLM