Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25451450
TITLE
Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Migraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background of bipolar patients with and without migraine.
METHODS NlmCategory: METHODS
We performed a genome-wide association analysis contrasting 460 bipolar migraneurs with 914 bipolar patients without migraine from the Bipolar Genome Study (BiGS).
RESULTS NlmCategory: RESULTS
We identified one genome-wide significant association between migraine in bipolar disorder patients and rs1160720, an intronic single nucleotide polymorphism (SNP) in the NBEA gene (P=2.97×10(-8), OR: 1.82, 95% CI: 1.47-2.25), although this was not replicated in a smaller sample of 289 migraine cases.
LIMITATIONS NlmCategory: CONCLUSIONS
Our study is based on self-reported migraine.
CONCLUSIONS NlmCategory: CONCLUSIONS
NBEA encodes neurobeachin, a scaffolding protein primarily expressed in the brain and involved in trafficking of vesicles containing neurotransmitter receptors. This locus has not previously been implicated in migraine per se. We found no evidence of association in data from the GWAS migraine meta-analysis consortium (n=118,710 participants) suggesting that the association might be specific to migraine co-morbid with bipolar disorder.
Copyright 2014 The Authors. Published by Elsevier B.V. All rights reserved.
DATE PUBLISHED
2015 Feb 1
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/05/19
revised 2014/10/02
accepted 2014/10/03
aheadofprint 2014/10/12
entrez 2014/12/03 06:00
pubmed 2014/12/03 06:00
medline 2014/12/03 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Jacobsen KK Jacobsen Kaya K KK KG Jebsen Center for Neurophyciatric research, Department of Biomedicine, University of Bergen, Bergen, Norway; Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway. Electronic address: kja098@biomed.uib.no.
Nievergelt CM Nievergelt Caroline M CM Department of Psychiatry, University of California, San Diego, USA.
Zayats T Zayats Tetyana T KG Jebsen Center for Neurophyciatric research, Department of Biomedicine, University of Bergen, Bergen, Norway; Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Greenwood TA Greenwood Tiffany A TA Department of Psychiatry, University of California, San Diego, USA.
Anttila V Anttila Verneri V Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Akiskal HS Akiskal Hagop S HS Department of Psychiatry, University of California, San Diego, USA; Department of Psychiatry, VA Hospital, San Diego, USA.
BiGS Consortium
IHG Consortium
BiGS Consortium Co-Authors include:
IHG Consortium Co-Authors include:
Haavik J Haavik Jan J KG Jebsen Center for Neurophyciatric research, Department of Biomedicine, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Bernt Fasmer O Bernt Fasmer Ole O KG Jebsen Center for Neurophyciatric research, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Kelsoe JR Kelsoe John R JR Department of Psychiatry, University of California, San Diego, USA; Department of Psychiatry, VA Hospital, San Diego, USA.
Johansson S Johansson Stefan S KG Jebsen Center for Neurophyciatric research, Department of Biomedicine, University of Bergen, Bergen, Norway; Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Norway.
Oedegaard KJ Oedegaard Ketil J KJ KG Jebsen Center for Neurophyciatric research, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Kelsoe John R JR
Greenwood Tiffany A TA
Nievergelt Caroline M CM
McKinney Rebecca R
Shilling Paul D PD
Smith Erin N EN
Schork Nicholas J NJ
Bloss Cinnamon S CS
Nurnberger John I JI
Edenberg Howard J HJ
Foroud Tatiana T
Koller Daniel L DL
Gershon Elliot S ES
Badner Judith A JA
Liu Chunyu C
Scheftner William A WA
Lawson William B WB
Nwulia Evaristus A EA
Hipolito Maria M
Potash James J
Coryell William W
Rice John J
Byerley William W
McMahon Francis J FJ
Berrettini Wade H WH
Zandi Peter P PP
Mahon Pamela B PB
McInnis Melvin G MG
Zöllner Sebastian S
Zhang Peng P
Craig David W DW
Szelinger Szabolics S
Barrett Thomas B TB
Schulze Thomas G TG
Wedenoja Juho J
Kaunisto Mari A MA
Heikkilä Kauko K
Kaprio Jaakko J
Wessman Maija M
Kallela Mikko M
Färkkilä Markus M
Artto Ville V
Aromaa Arpo A
Eriksson Johan G JG
Winsvold Bendik S BS
Zwart John-Anker JA
Gormley Padhraig P
Palotie Aarno A
Kurth Tobias T
Rose Lynda M LM
Buring Julie E JE
Ridker Paul M PM
Chasman Daniel I DI
Bettella Francesco F
Steinberg Stacy S
Stefansson Hreinn H
Stefansson Kari K
McMahon George G
Davey-Smith George G
Malik Rainer R
Freilinger Tobias T
Erich Wichmann Heinz H
Dichgans Martin M
Muller-Myhsok Bertram B
Meitinger Thomas T
de Vries Boukje B
Terwindt Gisela G
Stam Anine H AH
Frants Rune R RR
Pelzer Nadine N
Weller Claudia M CM
Zielman Ronald R
Ferrari Michel D MD
van den Maagdenberg Arn M J M AM
Medland Sarah E SE
Montgomery Grant W GW
Martin Nicholas G NG
Nyholt Dale R DR
Todt Unda U
Borck Guntram G
Kubisch Christian C
Quaye Lydia L
Williams Frances M K FM
Cherkas Lynn L
Koiranen Markku M
Hartikainen Anna-Liisa AL
Pouta Anneli A
Jarvelin Marjo-Riitta MR
Ikram M Arfan MA
van den Ende Joyce J
Uitterlinden Andre G AG
Hofman Albert A
Amin Najaf N
van Duijn Cornelia C
Lehtimäki Terho T
Ligthart Lannie L
Hottenga Jouke-Jan JJ
Vink Jacqueline M JM
Penninx Brenda W BW
Boomsma Dorret I DI
Schürks Markus M
Jakobsson Finnbogi F
Schoenen Jean J
Heath Andrew C AC
Madden Pamela A F PA
Göbel Hartmut H
Heinze Axel A
Heinze-Kuhn Katja K
Schreiber Stefan S
Anttila Verneri V
Daly Mark J MJ
Alexander Michael M
Raitakari Olli O
Strachan David P DP
JOURNAL
VOLUME: 172
ISSUE:
TITLE: Journal of affective disorders
ISOABBREVIATION: J Affect Disord
YEAR: 2015
MONTH: Feb
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1573-2517
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Affect Disord
COUNTRY: Netherlands
ISSNLINKING: 0165-0327
NLMUNIQUEID: 7906073
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 MH059567 NIMH NIH HHS United States
R01 MH078151 NIMH NIH HHS United States
R01 MH081804 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Bipolar disorder
Genetics
Migraine
NBEA
Neurobeachin
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS641861 NLM
PMC4394021 NLM