Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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25231870
TITLE
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
ABSTRACT
Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P < 5 × 10(-8)) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1-WDR25, MKRN3-MAGEL2 and KCNK9) demonstrating parent-of-origin-specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and γ-aminobutyric acid-B2 receptor signalling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition.
DATE PUBLISHED
2014 Oct 2
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2013/12/23
accepted 2014/05/30
aheadofprint 2014/07/23
entrez 2014/09/19 06:00
pubmed 2014/09/19 06:00
medline 2014/10/24 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Perry JR Perry John R B JR 1] MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. [2] University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK. [3] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. [4] Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK. [5].
Day F Day Felix F 1] MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. [2].
Elks CE Elks Cathy E CE 1] MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. [2].
Sulem P Sulem Patrick P 1] deCODE Genetics, Reykjavik IS-101, Iceland. [2].
Thompson DJ Thompson Deborah J DJ Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Ferreira T Ferreira Teresa T Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
He C He Chunyan C 1] Department of Epidemiology, Indiana University Richard M Fairbanks School of Public Health, Indianapolis, Indiana 46202, USA. [2] Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana 46202, USA.
Chasman DI Chasman Daniel I DI 1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA. [2] Harvard Medical School, Boston, Massachusetts 02115, USA.
Esko T Esko Tõnu T 1] Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia. [2] Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA. [3] Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge, Massachusetts 02142, USA. [4] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Thorleifsson G Thorleifsson Gudmar G deCODE Genetics, Reykjavik IS-101, Iceland.
Albrecht E Albrecht Eva E Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Ang WQ Ang Wei Q WQ School of Women's and Infants' Health, The University of Western Australia, WA-6009, Australia.
Corre T Corre Tanguy T 1] Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland. [2] Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.
Cousminer DL Cousminer Diana L DL Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00014, Finland.
Feenstra B Feenstra Bjarke B Department of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark.
Franceschini N Franceschini Nora N Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599-7400, USA.
Ganna A Ganna Andrea A Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
Johnson AD Johnson Andrew D AD NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.
Kjellqvist S Kjellqvist Sanela S Science for Life Laboratory, Karolinska Institutet, Stockholm, Box 1031, 17121 Solna, Sweden.
Lunetta KL Lunetta Kathryn L KL 1] NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA. [2] Boston University School of Public Health, Department of Biostatistics, Boston, Massachusetts 02118, USA.
McMahon G McMahon George G 1] MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK. [2] School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.
Nolte IM Nolte Ilja M IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Paternoster L Paternoster Lavinia L MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.
Porcu E Porcu Eleonora E 1] Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy. [2] University of Sassari, Department of Biomedical Sciences, 07100 Sassari, Italy.
Smith AV Smith Albert V AV 1] Icelandic Heart Association, IS-201 Kopavogur, Iceland. [2] University of Iceland, IS-101 Reykjavik, Iceland.
Stolk L Stolk Lisette L 1] Department of Internal Medicine, Erasmus MC, 3015 GE Rotterdam, the Netherlands. [2] Netherlands Consortium on Health Aging and National Genomics Initiative, 2300 RC Leiden, the Netherlands.
Teumer A Teumer Alexander A Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.
Tšernikova N Tšernikova Natalia N 1] Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia. [2] Department of Biotechnology, University of Tartu, 51010 Tartu, Estonia.
Tikkanen E Tikkanen Emmi E 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00014, Finland. [2] Hjelt Institute, University of Helsinki, FI-00014, Finland.
Ulivi S Ulivi Sheila S Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy.
Wagner EK Wagner Erin K EK 1] Department of Epidemiology, Indiana University Richard M Fairbanks School of Public Health, Indianapolis, Indiana 46202, USA. [2] Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana 46202, USA.
Amin N Amin Najaf N Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands.
Bierut LJ Bierut Laura J LJ Department of Psychiatry, Washington University, St Louis, Missouri 63110, USA.
Byrne EM Byrne Enda M EM 1] The University of Queensland, Queensland Brain Institute, St Lucia, Queensland 4072, Australia. [2] QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Hottenga JJ Hottenga Jouke-Jan JJ Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Koller DL Koller Daniel L DL Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202-3082, USA.
Mangino M Mangino Massimo M Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Pers TH Pers Tune H TH 1] Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA. [2] Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge, Massachusetts 02142, USA. [3] Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA. [4] Center for Biological Sequence Analysis, Department of Systems Biology, Technical 142 University of Denmark, DK-2800 Lyngby, Denmark.
Yerges-Armstrong LM Yerges-Armstrong Laura M LM Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Hua Zhao J Hua Zhao Jing J MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Andrulis IL Andrulis Irene L IL 1] Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Anton-Culver H Anton-Culver Hoda H Department of Epidemiology, University of California Irvine, Irvine, California 92697-7550, USA.
Atsma F Atsma Femke F Sanquin Research, 6525 GA Nijmegen, The Netherlands.
Bandinelli S Bandinelli Stefania S 1] Tuscany Regional Health Agency, Florence, Italy, I.O.T. and Department of Medical and Surgical Critical Care, University of Florence, 50134 Florence, Italy. [2] Geriatric Unit, Azienda Sanitaria di Firenze, 50122 Florence, Italy.
Beckmann MW Beckmann Matthias W MW University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, D-91054 Erlangen, Germany.
Benitez J Benitez Javier J 1] Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), E-28029 Madrid, Spain. [2] Centro de Investigación en Red de Enfermedades Raras (CIBERER), E-46010 Valencia, Spain.
Blomqvist C Blomqvist Carl C Department of Oncology, University of Helsinki and Helsinki University Central Hospital, FI-00100 Helsinki, Finland.
Bojesen SE Bojesen Stig E SE 1] Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, DK-2100 Copenhagen, Denmark. [2] Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Bolla MK Bolla Manjeet K MK Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Bonanni B Bonanni Bernardo B Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), 20139 Milan, Italy.
Brauch H Brauch Hiltrud H 1] DrMargarete Fischer-Bosch-Institute of Clinical Pharmacology, D-70376 Stuttgart, Germany. [2] University of Tübingen, D-72074 Tübingen, Germany.
Brenner H Brenner Hermann H 1] Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany. [2] German Cancer Consortium (DKTK), D-69120 Heidelberg, Germany.
Buring JE Buring Julie E JE 1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA. [2] Harvard Medical School, Boston, Massachusetts 02115, USA.
Chang-Claude J Chang-Claude Jenny J Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany.
Chanock S Chanock Stephen S Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Chen J Chen Jinhui J 1] Departments of Anatomy and Neurological Surgery, Indiana University school of Medicine, Indianapolis, Indiana 46202, USA. [2] Stark Neuroscience Research Center, Indiana University school of Medicine, Indianapolis, Indiana 46202, USA.
Chenevix-Trench G Chenevix-Trench Georgia G Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006 Australia.
Collée JM Collée J Margriet JM Department of Clinical Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
Couch FJ Couch Fergus J FJ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Couper D Couper David D Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599-7420, USA.
Coviello AD Coviello Andrea D AD Boston University School of Medicine, Department of Medicine, Sections of Preventive Medicine and Endocrinology, Boston, Massachusetts 02118, USA.
Cox A Cox Angela A Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK.
Czene K Czene Kamila K Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
D'adamo AP D'adamo Adamo Pio AP 1] Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy. [2] Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy.
Davey Smith G Davey Smith George G 1] MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK. [2] School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.
De Vivo I De Vivo Immaculata I 1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Demerath EW Demerath Ellen W EW Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Dennis J Dennis Joe J Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Devilee P Devilee Peter P Department of Human Genetics &Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Dieffenbach AK Dieffenbach Aida K AK 1] Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany. [2] German Cancer Consortium (DKTK), D-69120 Heidelberg, Germany.
Dunning AM Dunning Alison M AM Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge CB1 8RN, UK.
Eiriksdottir G Eiriksdottir Gudny G Icelandic Heart Association, IS-201 Kopavogur, Iceland.
Eriksson JG Eriksson Johan G JG 1] National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland. [2] Department of General Practice and Primary health Care, University of Helsinki, FI-00014 Helsinki, Finland. [3] Helsinki University Central Hospital, Unit of General Practice, FI-00029 HUS Helsinki, Finland. [4] Folkhalsan Research Centre, FI-00290 Helsinki, Finland.
Fasching PA Fasching Peter A PA University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, D-91054 Erlangen, Germany.
Ferrucci L Ferrucci Luigi L Longitudinal Studies Section, Clinical Research Branch, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 20892, USA.
Flesch-Janys D Flesch-Janys Dieter D Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, D-20246 Hamburg, Germany.
Flyger H Flyger Henrik H Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
Foroud T Foroud Tatiana T Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202-3082, USA.
Franke L Franke Lude L Department of Genetics, University of Groningen, University Medical Centre Groningen, P.O. Box 72, 9700 AB Groningen, The Netherlands.
Garcia ME Garcia Melissa E ME National Insitute on Aging, National Institutes of Health, Baltimore, Maryland 20892, USA.
García-Closas M García-Closas Montserrat M 1] Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK. [2] Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London SW3 6JB, UK.
Geller F Geller Frank F Department of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark.
de Geus EE de Geus Eco E J EE 1] Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands. [2] EMGO + Institute for Health and Care Research, VU University Medical Centre, Van der Boechorststraat 7, 1081 Bt, Amsterdam, The Netherlands.
Giles GG Giles Graham G GG 1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia. [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Gudbjartsson DF Gudbjartsson Daniel F DF 1] deCODE Genetics, Reykjavik IS-101, Iceland. [2] Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland.
Gudnason V Gudnason Vilmundur V 1] Icelandic Heart Association, IS-201 Kopavogur, Iceland. [2] University of Iceland, IS-101 Reykjavik, Iceland.
Guénel P Guénel Pascal P 1] Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, F-94807 Villejuif, France. [2] University Paris-Sud, UMRS 1018, F-94807 Villejuif, France.
Guo S Guo Suiqun S Department of Obstetrics and Gynecology, Southern Medical University, 510515 Guangzhou, China.
Hall P Hall Per P Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
Hamann U Hamann Ute U Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), D-69120 Heidelberg, Germany.
Haring R Haring Robin R Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.
Hartman CA Hartman Catharina A CA Department of Psychiatry, University of Groningen, University Medical Center Groningen, P.O. Box 72, 9700 AB Groningen, The Netherlands.
Heath AC Heath Andrew C AC Washington University, Department of Psychiatry, St Louis, Missouri 63110, USA.
Hofman A Hofman Albert A Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, the Netherlands.
Hooning MJ Hooning Maartje J MJ Department of Medical Oncology, Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
Hopper JL Hopper John L JL Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Hu FB Hu Frank B FB 1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. [3] Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Hunter DJ Hunter David J DJ 1] Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge, Massachusetts 02142, USA. [2] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA. [3] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Karasik D Karasik David D 1] Harvard Medical School, Boston, Massachusetts 02115, USA. [2] Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts 02131, USA.
Kiel DP Kiel Douglas P DP 1] Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts 02131, USA. [2] Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA.
Knight JA Knight Julia A JA 1] Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. [2] Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario M5T 3M7, Canada.
Kosma VM Kosma Veli-Matti VM 1] School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland. [2] Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, P.O. Box 100, FI-70029 Kuopio, Finland.
Kutalik Z Kutalik Zoltan Z 1] Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland. [2] Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.
Lai S Lai Sandra S Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy.
Lambrechts D Lambrechts Diether D 1] Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium. [2] Laboratory for Translational Genetics, Department of Oncology, University of Leuven, 3000 Leuven, Belgium.
Lindblom A Lindblom Annika A Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Mägi R Mägi Reedik R Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Magnusson PK Magnusson Patrik K PK Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
Mannermaa A Mannermaa Arto A 1] School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland. [2] Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, P.O. Box 100, FI-70029 Kuopio, Finland.
Martin NG Martin Nicholas G NG Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006 Australia.
Masson G Masson Gisli G deCODE Genetics, Reykjavik IS-101, Iceland.
McArdle PF McArdle Patrick F PF Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
McArdle WL McArdle Wendy L WL School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.
Melbye M Melbye Mads M 1] Department of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark. [2] Department of Medicine, Stanford School of Medicine, Stanford, California 94305-5101, USA.
Michailidou K Michailidou Kyriaki K Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Mihailov E Mihailov Evelin E 1] Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia. [2] Department of Biotechnology, University of Tartu, 51010 Tartu, Estonia.
Milani L Milani Lili L Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Milne RL Milne Roger L RL 1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia. [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Nevanlinna H Nevanlinna Heli H Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, P.O. Box 100, FI-00029 HUS Helsinki, Finland.
Neven P Neven Patrick P KULeuven (University of Leuven), Department of Oncology, Multidisciplinary Breast Center, University Hospitals Leuven, 3000 Leuven, Belgium.
Nohr EA Nohr Ellen A EA Research Unit of Obstetrics &Gynecology, Institute of Clinical Research, University of Southern Denmark, DK-5000 Odense C, Denmark.
Oldehinkel AJ Oldehinkel Albertine J AJ Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Oostra BA Oostra Ben A BA Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands.
Palotie A Palotie Aarno A 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00014, Finland. [2] Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. [3] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA. [4] Psychiatric &Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Peacock M Peacock Munro M Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
Peterlongo P Peterlongo Paolo P IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, 20139 Milan, Italy.
Peto J Peto Julian J Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Pharoah PD Pharoah Paul D P PD Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge CB1 8RN, UK.
Postma DS Postma Dirkje S DS University Groningen, University Medical Center Groningen, Department Pulmonary Medicine and Tuberculosis, GRIAC Research Institute, P.O. Box 30.001, NL-9700 RB Groningen, The Netherlands.
Pouta A Pouta Anneli A 1] National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland. [2] Department of Obstetrics and Gynecology, Oulu University Hospital, P.O. Box 10, FI-90029 OYS Oulu, Finland.
Pylkäs K Pylkäs Katri K Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital/NordLab Oulu, P.O. Box 3000, FI-90014 Oulu, Finland.
Radice P Radice Paolo P Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133 Milan, Italy.
Ring S Ring Susan S 1] MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK. [2] School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.
Rivadeneira F Rivadeneira Fernando F 1] Department of Internal Medicine, Erasmus MC, 3015 GE Rotterdam, the Netherlands. [2] Netherlands Consortium on Health Aging and National Genomics Initiative, 2300 RC Leiden, the Netherlands. [3] Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, the Netherlands.
Robino A Robino Antonietta A 1] Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy. [2] Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy.
Rose LM Rose Lynda M LM Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.
Rudolph A Rudolph Anja A Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany.
Salomaa V Salomaa Veikko V National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland.
Sanna S Sanna Serena S Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy.
Schlessinger D Schlessinger David D National Institute on Aging, Intramural Research Program, Baltimore, Maryland 21224-6825, USA.
Schmidt MK Schmidt Marjanka K MK Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Postbus 90203, 1006 BE Amsterdam, The Netherlands.
Southey MC Southey Mellissa C MC Department of Pathology, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Sovio U Sovio Ulla U 1] Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK. [2] Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge CB2 0SW, UK.
Stampfer MJ Stampfer Meir J MJ 1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. [3] Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Stöckl D Stöckl Doris D 1] Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, D-8576 Neuherberg, Germany. [2] Department of Obstetrics and Gynaecology, Campus Grosshadern, Ludwig-Maximilians-University, D-81377 Munich, Germany.
Storniolo AM Storniolo Anna M AM Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Timpson NJ Timpson Nicholas J NJ 1] MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK. [2] School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.
Tyrer J Tyrer Jonathan J Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge CB1 8RN, UK.
Visser JA Visser Jenny A JA Department of Internal Medicine, Erasmus MC, 3015 GE Rotterdam, the Netherlands.
Vollenweider P Vollenweider Peter P Department of Internal Medicine, Lausanne University Hospital, CH-1015 Lausanne, Switzerland.
Völzke H Völzke Henry H 1] Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany. [2] DZHK (German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany.
Waeber G Waeber Gerard G Department of Internal Medicine, Lausanne University Hospital, CH-1015 Lausanne, Switzerland.
Waldenberger M Waldenberger Melanie M Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-8576 Neuherberg, Germany.
Wallaschofski H Wallaschofski Henri H 1] Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany. [2] DZHK (German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany.
Wang Q Wang Qin Q Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Willemsen G Willemsen Gonneke G Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Winqvist R Winqvist Robert R Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital/NordLab Oulu, P.O. Box 3000, FI-90014 Oulu, Finland.
Wolffenbuttel BH Wolffenbuttel Bruce H R BH Department of Endocrinology, University of Groningen, University Medical Centre Groningen, P.O. Box 72, 9700 AB Groningen, The Netherlands.
Wright MJ Wright Margaret J MJ Queensland Insitute of Medical Research, Brisbane, Queensland 4029, Australia.
Australian Ovarian Cancer Study
GENICA Network
kConFab
LifeLines Cohort Study
InterAct Consortium
Early Growth Genetics (EGG) Consortium
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Econs MJ Econs Michael J MJ 1] Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202-3082, USA. [2] Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Khaw KT Khaw Kay-Tee KT Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 0QQ, UK.
Loos RJ Loos Ruth J F RJ 1] MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. [2] Genetics of Obesity and Related Metabolic Traits Program, The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, Box 1003, New York, New York 10029, USA.
McCarthy MI McCarthy Mark I MI 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. [2] NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LE, UK. [3] Oxford Centre for Diabetes, Endocrinology, &Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.
Montgomery GW Montgomery Grant W GW Queensland Insitute of Medical Research, Brisbane, Queensland 4029, Australia.
Rice JP Rice John P JP Department of Psychiatry, Washington University, St Louis, Missouri 63110, USA.
Streeten EA Streeten Elizabeth A EA 1] Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. [2] Geriatric Research and Education Clinical Center (GRECC) - Veterans Administration Medical Center, Baltimore, Maryland 21201, USA.
Thorsteinsdottir U Thorsteinsdottir Unnur U 1] deCODE Genetics, Reykjavik IS-101, Iceland. [2] Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland.
van Duijn CM van Duijn Cornelia M CM 1] Netherlands Consortium on Health Aging and National Genomics Initiative, 2300 RC Leiden, the Netherlands. [2] Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands. [3] Centre of Medical Systems Biology, PO Box 9600, 2300 RC Leiden, the Netherlands.
Alizadeh BZ Alizadeh Behrooz Z BZ Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Bergmann S Bergmann Sven S 1] Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland. [2] Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.
Boerwinkle E Boerwinkle Eric E Human Genetics Center and Divof Epidemiology, University of Houston, P.O. Box 20186, Texas 77025 USA.
Boyd HA Boyd Heather A HA Department of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark.
Crisponi L Crisponi Laura L Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy.
Gasparini P Gasparini Paolo P 1] Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy. [2] Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy.
Gieger C Gieger Christian C Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Harris TB Harris Tamara B TB National Insitute on Aging, National Institutes of Health, Baltimore, Maryland 20892, USA.
Ingelsson E Ingelsson Erik E Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Box 256, 751 05 Uppsala, Sweden.
Järvelin MR Järvelin Marjo-Riitta MR 1] Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK. [2] Institute of Health Sciences, University of Oulu, P.O. Box 5000, FI-90014 Oulu, Finland. [3] Biocenter Oulu, University of Oulu, P.O. Box 5000, Aapistie 5A, FI-90014 Oulu, Finland. [4] Department of Children and Young People and Families, National Institute for Health and Welfare, Aapistie 1, Box 310, FI-90101 Oulu, Finland. [5] Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O. Box 20, FI-90220 Oulu, 90029 OYS, Finland.
Kraft P Kraft Peter P 1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA. [2] Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Lawlor D Lawlor Debbie D 1] MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK. [2] School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.
Metspalu A Metspalu Andres A 1] Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia. [2] Department of Biotechnology, University of Tartu, 51010 Tartu, Estonia.
Pennell CE Pennell Craig E CE School of Women's and Infants' Health, The University of Western Australia, WA-6009, Australia.
Ridker PM Ridker Paul M PM 1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA. [2] Harvard Medical School, Boston, Massachusetts 02115, USA.
Snieder H Snieder Harold H Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Sørensen TI Sørensen Thorkild I A TI 1] Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Denmark. [2] Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, DK-2000 Frederiksberg, Denmark.
Spector TD Spector Tim D TD Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Strachan DP Strachan David P DP Division of Population Health Sciences and Education, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
Uitterlinden AG Uitterlinden André G AG 1] Department of Internal Medicine, Erasmus MC, 3015 GE Rotterdam, the Netherlands. [2] Netherlands Consortium on Health Aging and National Genomics Initiative, 2300 RC Leiden, the Netherlands. [3] Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, the Netherlands.
Wareham NJ Wareham Nicholas J NJ MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Widen E Widen Elisabeth E Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00014, Finland.
Zygmunt M Zygmunt Marek M Department of Obstetrics and Gynecology, University Medicine Greifswald, D-17475 Greifswald, Germany.
Murray A Murray Anna A University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Easton DF Easton Douglas F DF Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Stefansson K Stefansson Kari K 1] deCODE Genetics, Reykjavik IS-101, Iceland. [2] Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland. [3].
Murabito JM Murabito Joanne M JM 1] NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA. [2] Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, Massachusetts 02118, USA. [3].
Ong KK Ong Ken K KK 1] MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. [2] Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK. [3].
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Cousminer Diana L DL
Stergiakouli Evangelia E
Berry Diane J DJ
Ang Wei W
Groen-Blokhuis Maria M MM
Körner Antje A
Siitonen Niina N
Ntalla Ioanna I
Marinelli Marcella M
Perry John R B JR
Kettunen Johannes J
Jansen Rick R
Surakka Ida I
Timpson Nicholas J NJ
Ring Susan S
McMahon George G
Power Chris C
Wang Carol C
Kähönen Mika M
Viikari Jorma J
Lehtimäki Terho T
Middeldorp Christel M CM
Hulshoff Pol Hilleke E HE
Neef Madlen M
Weise Sebastian S
Pahkala Katja K
Niinikoski Harri H
Zeggini Eleftheria E
Panoutsopoulou Kalliope K
Bustamante Mariona M
Penninx Brenda W J H BW
Murabito Joanne J
Torrent Maties M
Dedoussis George V GV
Kiess Wieland W
Boomsma Dorret I DI
Pennell Craig E CE
Raitakari Olli T OT
Hyppönen Elina E
Davey Smith George G
Ripatti Samuli S
McCarthy Mark I MI
Widén Elisabeth E
Alizadeh Behrooz Z BZ
de Boer Rudolf A RA
Boezen H Marike HM
Bruinenberg Marcel M
Franke Lude L
van der Harst Pim P
Hillege Hans L HL
van der Klauw Melanie M MM
Navis Gerjan G
Ormel Johan J
Postma Dirkje S D
Rosmalen Judith G M JG
Slaets Joris P JP
Snieder Harold H
Stolk Ronald P RP
Wolffenbuttel Bruce H R BH
Wijmenga Cisca C
Forouhi Nita G N
Kerrison Nicola D ND
Langenberg Claudia C
Scott Robert A RA
Sharp Stephen J SJ
Sims Matt M
Barroso Inês I
Deloukas Panos P
McCarthy Mark I MI
Arriola Larraitz L
Balkau Beverley B
Barricarte Aurelio A
Boeing Heiner H
Franks Paul W PW
Gonzalez Carlos C
Grioni Sara S
Kaaks Rudolf R
Key Timothy J TJ
Navarro Carmen C
Nilsson Peter M PM
Overvad Kim K
Palli Domenico D
Panico Salvatore S
Quirós J Ramón J
Rolandsson Olov O
Sacerdote Carlotta C
Sánchez María-José MJ
Slimani Nadia N
Tjonneland Anne A
Tumino Rosario R
van der A Daphne L DL
van der Schouw Yvonne T YT
Riboli Elio E
Wareham Nicholas J NJ
Bowtell David D DD
Green Adele C A
Chenevix-Trench Georgia G
deFazio Anna A
Gertig Dorota D
Webb Penelope M PM
Brauch Hiltrud H
Justenhoven Christina C
Hamann Ute U
Ko Yon-Dschun YD
Baisch Christian C
Fischer Hans-Peter HP
Pesch Beate B
Rabstein Sylvia S
Spickenheuer Anne A
Harth Volker V
Aghmesheh Morteza M
Amor David D
Andrews Lesley L
Antill Yoland Y
Armitage Shane S
Arnold Leanne L
Balleine Rosemary R
Bankier Agnes A
Bastick Patti P
Beesley Jonathan J
Beilby John J
Bennett Ian I
Bennett Barbara B
Berry Geoffrey G
Blackburn Anneke A
Bogwitz Michael M
Brennan Meagan M
Brown Melissa M
Buckley Michael M
Burgess Matthew M
Burke Jo J
Butow Phyllis P
Byron Keith K
Callen David D
Campbell Ian I
Chauhan Deepa D
Chenevix-Trench Georgia G
Christian Alice A
Clarke Christine C
Colley Alison A
Cotton Dick D
Crook Ashley A
Cui James J
Culling Bronwyn B
Cummings Margaret M
Dawson Sarah-Jane SJ
deFazio Anna A
Delatycki Martin M
Dickson Rebecca R
Dixon Joanne J
Dobrovic Alexander A
Dudding Tracy T
Edkins Ted T
Edwards Stacey S
Eisenbruch Maurice M
Farshid Gelareh G
Fawcett Susan S
Fellows Andrew A
Fenton Georgina G
Field Michael M
Firgaira Frank F
Flanagan James J
Fleming Jean J
Fong Peter P
Forbes John J
Fox Stephen S
French Juliet J
Friedlander Michael M
Gaff Clara C
Gardner Mac M
Gattas Mike M
George Peter P
Giles Graham G
Gill Grantley G
Goldblatt Jack J
Greening Sian S
Grist Scott S
Eric Haan H
Hardie Kate K
Harris Marion M
Hart Stewart S
Hayward Nick N
Healey Sue S
Heiniger Louise L
Hopper John J
Humphrey Evelyn E
Hunt Clare C
James Paul P
Jenkins Mark M
Jones Alison A
Kefford Rick R
Kidd Alexa A
Kiely Belinda B
Kirk Judy J
Koehler Jessica J
Kollias James J
Kovalenko Serguei S
Lakhani Sunil S
Leaming Amanda A
Leary Jennifer J
Lim Jacqueline J
Lindeman Geoff G
Lipton Lara L
Lobb Liz L
Mann Graham G
Marsh Deborah D
McLachlan Sue Anne SA
Meiser Bettina B
Meldrum Cliff C
Milne Roger R
Mitchell Gillian G
Newman Beth B
O'Connell Shona S
O'Loughlin Imelda I
Osborne Richard R
Pachter Nick N
Patterson Briony B
Peters Lester L
Phillips Kelly K
Price Melanie M
Purser Lynne L
Reeve Jeanne J
Reeve Tony T
Richards Robert R
Rickard Edwina E
Robinson Bridget B
Rudzki Barney B
Saleh Mona M
Salisbury Elizabeth E
Sambrook Joe J
Saunders Christobel C
Saunus Jodi J
Sayer Robyn R
Scott Elizabeth E
Scott Rodney R
Scott Clare C
Seshadri Ram R
Sexton Adrienne A
Sharma Raghwa R
Shelling Andrew A
Simpson Peter P
Southey Melissa M
Spurdle Amanda A
Suthers Graeme G
Sykes Pamela P
Taylor Donna D
Taylor Jessica J
Thierry Benjamin B
Thompson Ella E
Thorne Heather H
Townshend Sharron S
Trainer Alison A
Tran Lan L
Tucker Kathy K
Tyler Janet J
Visvader Jane J
Walker Logan L
Walpole Ian I
Waring Paul P
Warner Bev B
Warren Graham G
Williams Rachael R
Wilson Judy J
Winship Ingrid I
Wu Kathy K
Young Mary Ann MA
JOURNAL
VOLUME: 514
ISSUE: 7520
TITLE: Nature
ISOABBREVIATION: Nature
YEAR: 2014
MONTH: Oct
DAY: 2
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-4687
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nature
COUNTRY: England
ISSNLINKING: 0028-0836
NLMUNIQUEID: 0410462
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
098381 Wellcome Trust United Kingdom
10118 Cancer Research UK United Kingdom
G0701863 Medical Research Council United Kingdom
G1000143 Medical Research Council United Kingdom
G9815508 Medical Research Council United Kingdom
MC_PC_15018 Medical Research Council United Kingdom
MC_U106179471 Medical Research Council United Kingdom
MC_U106179472 Medical Research Council United Kingdom
MC_UU_12013/1 Medical Research Council United Kingdom
MC_UU_12013/3 Medical Research Council United Kingdom
MC_UU_12015/1 Medical Research Council United Kingdom
MC_UU_12015/2 Medical Research Council United Kingdom
MR/J012165/1 Medical Research Council United Kingdom
P50 CA116201 NCI NIH HHS United States
R01 AG041517 NIA NIH HHS United States
U01 AG049505 NIA NIH HHS United States
UL1 TR001108 NCATS NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Age Factors
Alleles
Body Mass Index
Breast Neoplasms genetics
Cardiovascular Diseases genetics
Child genetics
Diabetes Mellitus, Type 2 genetics
Europe ethnology
Female ethnology
Genetic Loci genetics
Genome-Wide Association Study genetics
Genomic Imprinting genetics
Humans genetics
Hypothalamo-Hypophyseal System physiology
Intercellular Signaling Peptides and Proteins genetics
Male genetics
Membrane Proteins genetics
Menarche genetics
Obesity genetics
Ovary physiology
Parents physiology
Polymorphism, Single Nucleotide genetics
Potassium Channels, Tandem Pore Domain genetics
Proteins genetics
Quantitative Trait Loci genetics
Receptors, GABA-B metabolism
Receptors, Retinoic Acid metabolism
Ribonucleoproteins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 DLK1 protein, human
0 Intercellular Signaling Peptides and Proteins
0 KCNK9 protein, human
0 MAGEL2 protein, human
0 MKRN3 protein, human
0 Membrane Proteins
0 Potassium Channels, Tandem Pore Domain
0 Proteins
0 Receptors, GABA-B
0 Receptors, Retinoic Acid
0 Ribonucleoproteins
0 WDR25 protein, human
OTHER ID's
OTHERID SOURCE
EMS58897 NLM
PMC4185210 NLM