Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25132021
TITLE
Heritability of head motion during resting state functional MRI in 462 healthy twins.
ABSTRACT
Head motion (HM) is a critical confounding factor in functional MRI. Here we investigate whether HM during resting state functional MRI (RS-fMRI) is influenced by genetic factors in a sample of 462 twins (65% female; 101 MZ (monozygotic) and 130 DZ (dizygotic) twin pairs; mean age: 21 (SD = 3.16), range 16-29). Heritability estimates for three HM components-mean translation (MT), maximum translation (MAXT) and mean rotation (MR)-ranged from 37 to 51%. We detected a significant common genetic influence on HM variability, with about two-thirds (genetic correlations range 0.76-1.00) of the variance shared between MR, MT and MAXT. A composite metric (HM-PC1), which aggregated these three, was also moderately heritable (h(2) = 42%). Using a sub-sample (N = 35) of the twins we confirmed that mean and maximum translational and rotational motions were consistent "traits" over repeated scans (r = 0.53-0.59); reliability was even higher for the composite metric (r = 0.66). In addition, phenotypic and cross-trait cross-twin correlations between HM and resting state functional connectivities (RS-FCs) with Brodmann areas (BA) 44 and 45, in which RS-FCs were found to be moderately heritable (BA44: h(2) = 0.23 (sd = 0.041), BA45: h(2) = 0.26 (sd = 0.061)), indicated that HM might not represent a major bias in genetic studies using FCs. Even so, the HM effect on FC was not completely eliminated after regression. HM may be a valuable endophenotype whose relationship with brain disorders remains to be elucidated.
Copyright 2014 Elsevier Inc. All rights reserved.
DATE PUBLISHED
2014 Nov 15
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2013/02/11
revised 2014/08/01
accepted 2014/08/05
aheadofprint 2014/08/13
entrez 2014/08/19 06:00
pubmed 2014/08/19 06:00
medline 2015/08/04 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Couvy-Duchesne B Couvy-Duchesne Baptiste B QIMR Berghofer Medical Research Institute, Brisbane, Australia; School of Psychology, University of Queensland, Brisbane, Australia; Centre for Advanced Imaging, University of Queensland, Brisbane, Australia. Electronic address: baptiste.couvyduchesne@qimrberghofer.edu.au.
Blokland GA Blokland Gabriëlla A M GA QIMR Berghofer Medical Research Institute, Brisbane, Australia; School of Psychology, University of Queensland, Brisbane, Australia.
Hickie IB Hickie Ian B IB Brain & Mind Research Institute, University of Sydney, Australia.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Laboratory of Neuro-Imaging, Dept. of Neurology & Psychiatry, UCLA School of Medicine, Los Angeles, CA, USA.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Australia.
de Zubicaray GI de Zubicaray Greig I GI School of Psychology, University of Queensland, Brisbane, Australia.
McMahon KL McMahon Katie L KL Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.
Wright MJ Wright Margaret J MJ QIMR Berghofer Medical Research Institute, Brisbane, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 102 Pt 2
ISSUE:
TITLE: NeuroImage
ISOABBREVIATION: Neuroimage
YEAR: 2014
MONTH: Nov
DAY: 15
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1095-9572
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neuroimage
COUNTRY: United States
ISSNLINKING: 1053-8119
NLMUNIQUEID: 9215515
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 AG040060 NIA NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
R01HD050735 NICHD NIH HHS United States
RF1 AG041915 NIA NIH HHS United States
U54 EB020403 NIBIB NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Broca's area
Head motion
Heritability
Resting state fMRI
Twin study
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Brain physiology
Brain Mapping physiology
Endophenotypes physiology
Female physiology
Head Movements physiology
Humans physiology
Magnetic Resonance Imaging physiology
Male physiology
Nerve Net physiology
Rest physiology
Twins, Dizygotic physiology
Twins, Monozygotic physiology
Young Adult physiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS622545 NLM
PMC4252775 NLM