Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25078964
TITLE
Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index.
ABSTRACT
The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits increased phenotypic variance in the heterozygous genotype group relative to the homozygous groups. We applied the method to >56,000 unrelated individuals to search for POEs influencing body mass index (BMI). Six lead SNPs were carried forward for replication in five family-based studies (of ∼4,000 trios). Two SNPs replicated: the paternal rs2471083-C allele (located near the imprinted KCNK9 gene) and the paternal rs3091869-T allele (located near the SLC2A10 gene) increased BMI equally (beta = 0.11 (SD), P<0.0027) compared to the respective maternal alleles. Real-time PCR experiments of lymphoblastoid cell lines from the CEPH families showed that expression of both genes was dependent on parental origin of the SNPs alleles (P<0.01). Our scheme opens new opportunities to exploit GWAS data of unrelated individuals to identify POEs and demonstrates that they play an important role in adult obesity.
DATE PUBLISHED
2014 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
ecollection 2014/07
received 2014/02/05
accepted 2014/05/14
epublish 2014/07/31
entrez 2014/08/01 06:00
pubmed 2014/08/01 06:00
medline 2015/02/13 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hoggart CJ Hoggart Clive J CJ Department of Genomics of Common Disease, Imperial College London, London, United Kingdom.
Venturini G Venturini Giulia G Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
Mangino M Mangino Massimo M Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom.
Gomez F Gomez Felicia F Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America.
Ascari G Ascari Giulia G Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
Zhao JH Zhao Jing Hua JH MRC-Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
Teumer A Teumer Alexander A Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Winkler TW Winkler Thomas W TW Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Tšernikova N Tšernikova Natalia N Estonian Genome Center, University of Tartu, Tartu, Estonia; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Luan J Luan Jian'an J MRC-Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
Mihailov E Mihailov Evelin E Estonian Genome Center, University of Tartu, Tartu, Estonia; Estonian Biocentre, Tartu, Estonia.
Ehret GB Ehret Georg B GB McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Center for Complex Disease Genomics, Baltimore, Maryland, United States of America; Cardiology, Geneva University Hospitals, Geneva, Switzerland.
Zhang W Zhang Weihua W Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Lamparter D Lamparter David D Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Esko T Esko Tõnu T Center for Basic and Translational Obesity Research and Divisions of Endocrinology and Genetics, Boston Children's Hospital, Boston, Massachusetts, United States of America; Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.
Macé A Macé Aurelien A Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Rüeger S Rüeger Sina S Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Bochud PY Bochud Pierre-Yves PY Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Barcella M Barcella Matteo M Department of Health Sciences, University of Milan, Milan, Italy.
Dauvilliers Y Dauvilliers Yves Y INSERM-U1061, Montpellier, France; National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), Department of Neurology, Gui-de-Chauliac Hospital, Montpellier, France.
Benyamin B Benyamin Beben B Queensland Brain Institute, University of Queensland, Brisbane, Australia; Genetic Epidemiology, QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
Evans DM Evans David M DM MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; Diamantina Institute, Translational Research Institute, University of Queensland, Brisbane, Australia.
Hayward C Hayward Caroline C MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Lopez MF Lopez Mary F MF Center for Basic and Translational Obesity Research and Divisions of Endocrinology and Genetics, Boston Children's Hospital, Boston, Massachusetts, United States of America; Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
Franke L Franke Lude L Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Russo A Russo Alessia A Genomic Variation in Human Populations and Complex Diseases Unit, Human Genetics Foundation and Dept. of Medical Sciences, University of Turin, Turin, Italy.
Heid IM Heid Iris M IM Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Salvi E Salvi Erika E Department of Health Sciences, University of Milan, Milan, Italy.
Vendantam S Vendantam Sailaja S Center for Basic and Translational Obesity Research and Divisions of Endocrinology and Genetics, Boston Children's Hospital, Boston, Massachusetts, United States of America; Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.
Arking DE Arking Dan E DE McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Center for Complex Disease Genomics, Baltimore, Maryland, United States of America.
Boerwinkle E Boerwinkle Eric E Human Genetics Center, Houston, Texas, United States of America.
Chambers JC Chambers John C JC Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Fiorito G Fiorito Giovanni G Genomic Variation in Human Populations and Complex Diseases Unit, Human Genetics Foundation and Dept. of Medical Sciences, University of Turin, Turin, Italy.
Grallert H Grallert Harald H Research Unit Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
Guarrera S Guarrera Simonetta S Genomic Variation in Human Populations and Complex Diseases Unit, Human Genetics Foundation, Turin, Italy.
Homuth G Homuth Georg G Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Huffman JE Huffman Jennifer E JE MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Porteous D Porteous David D Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Generation Scotland Consortium
LifeLines Cohort study
GIANT Consortium
Moradpour D Moradpour Darius D Department of Medicine, Service of Gastroenterology and Hepatology, Lausanne, Switzerland.
Iranzo A Iranzo Alex A Neurology Service, Hospital Clinic, Barcelona, Spain.
Hebebrand J Hebebrand Johannes J Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany.
Kemp JP Kemp John P JP MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
Lammers GJ Lammers Gert J GJ Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands; Sleep Wake Center SEIN, Heemstede, The Netherlands.
Aubert V Aubert Vincent V Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Heim MH Heim Markus H MH Department of Gastroenterology, University Hospital Basel, Basel, Switzerland.
Martin NG Martin Nicholas G NG Genetic Epidemiology, QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
Montgomery GW Montgomery Grant W GW Molecular Epidemiology, QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
Peraita-Adrados R Peraita-Adrados Rosa R Sleep and Epilepsy Unit - Clinical Neurophysiology Department, Gregorio Marañón University Hospital, Madrid, Spain.
Santamaria J Santamaria Joan J Neurology Service, Hospital Clinic, Barcelona, Spain.
Negro F Negro Francesco F Service of Gastroenterology and Hepatology, Service of Clinical Pathology, Geneva, Switzerland.
Schmidt CO Schmidt Carsten O CO Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Scott RA Scott Robert A RA MRC-Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
Spector TD Spector Tim D TD Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom.
Strauch K Strauch Konstantin K Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.
Völzke H Völzke Henry H Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Wareham NJ Wareham Nicholas J NJ MRC-Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
Yuan W Yuan Wei W Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom.
Bell JT Bell Jordana T JT Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom.
Chakravarti A Chakravarti Aravinda A McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Center for Complex Disease Genomics, Baltimore, Maryland, United States of America.
Kooner JS Kooner Jaspal S JS Cardiovascular Science, National Heart & Lung Institute, Imperial College London, London, United Kingdom.
Peters A Peters Annette A Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany; Deutsches Zentrum für Diabetes, Neuherberg, Germany.
Matullo G Matullo Giuseppe G Genomic Variation in Human Populations and Complex Diseases Unit, Human Genetics Foundation and Dept. of Medical Sciences, University of Turin, Turin, Italy.
Wallaschofski H Wallaschofski Henri H Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Whitfield JB Whitfield John B JB Genetic Epidemiology, QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
Paccaud F Paccaud Fred F Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Vollenweider P Vollenweider Peter P Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Bergmann S Bergmann Sven S Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Beckmann JS Beckmann Jacques S JS Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Tafti M Tafti Mehdi M Center for Integrative Genomics (CIG), University of Lausanne, Lausanne, Switzerland; Center for Investigation and Research in Sleep (CIRS), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Hastie ND Hastie Nicholas D ND MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Cusi D Cusi Daniele D Department of Health Sciences, University of Milan, Milan, Italy.
Bochud M Bochud Murielle M Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Frayling TM Frayling Timothy M TM University of Exeter Medical School, University of Exeter, Exeter, United Kingdom.
Metspalu A Metspalu Andres A Estonian Genome Center, University of Tartu, Tartu, Estonia; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia; Estonian Biocentre, Tartu, Estonia.
Jarvelin MR Jarvelin Marjo-Riitta MR Institute of Health Sciences, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland; Department of Epidemiology and Biostatistics, School of Public Health, MRC-HPA Centre for Environment and Health, Faculty of Medicine, Imperial College London, London, United Kingdom; Unit of Primary Care, Oulu University Hospital, Oulu, Finland.
Scherag A Scherag André A Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany; Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.
Smith GD Smith George Davey GD MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
Borecki IB Borecki Ingrid B IB Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America.
Rousson V Rousson Valentin V Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Hirschhorn JN Hirschhorn Joel N JN Center for Basic and Translational Obesity Research and Divisions of Endocrinology and Genetics, Boston Children's Hospital, Boston, Massachusetts, United States of America; Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.
Rivolta C Rivolta Carlo C Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
Loos RJ Loos Ruth J F RJ MRC-Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom; The Charles Bronfman Institute of Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Kutalik Z Kutalik Zoltán Z Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
de Bakker P P
Bültmann U U
Geleijnse M M
Harst P v d Pv
Koppelman G G
Rosmalen J G M JG
van Rossum L L
Smidt H H
Swertz M A MA
Stolk R P RP
Alizadeh B B
de Boer R R
Boezen H M HM
Bruinenberg M M
Franke L L
van der Harst P P
Hillege H H
van der Klauw M M
Navis G G
Ormel J J
Postma D D
Rosmalen J J
Slaets J J
Snieder H H
Stolk R R
Wolffenbuttel B B
Wijmenga C C
Berg Jonathan J
Blackwood Douglas D
Campbell Harry H
Cavanagh Jonathan J
Connell John J
Connor Mike M
Cunningham-Burley Sarah S
Deary Ian I
Dominiczak Anna A
Ellis Paul P
FitzPatrick Bridie B
Ford Ian I
Gertz Rena R
Grau Antonio A
Haddow Gill G
Jackson Cathy C
Kerr Shona S
Lindsay Robbie R
McGilchrist Mark M
McIntyre Donald D
Morris Andrew A
Morton Robin R
Muir Walter W
Murray Graeme G
Palmer Colin C
Pell Jill J
Philp Alastair A
Porteous David D
Porteous Mary M
Procter Rob R
Ralston Stuart S
Reid David D
Sinnott Richard R
Smith Blair B
Clair David St DS
Sullivan Frank F
Sweetland Mary M
Ure Jenny J
Watt Graham G
Wolf Roland R
Wright Alan A
Berndt Sonja I SI
Gustafsson Stefan S
Mägi Reedik R
Ganna Andrea A
Wheeler Eleanor E
Feitosa Mary F MF
Justice Anne E AE
Monda Keri L KL
Croteau- Chonka Damien C DC
Day Felix R FR
Esko Tonu T
Fall Tove T
Ferreira Teresa T
Gentilini Davide D
Jackson Anne U AU
Luan Jian'an J
Randall Joshua C JC
Vedantam Sailaja S
Willer Cristen J CJ
Winkler Thomas W TW
Wood Andrew R AR
Workalemahu Tsegaselassie T
Hu Yi-Juan YJ
Lee Sang Hong SH
Liang Liming L
Lin Dan-Yu DY
Min Josine L JL
Neale Benjamin M BM
Thorleifsson Gudmar G
Yang Jian J
Albrecht Eva E
Amin Najaf N
Bragg-Gresham Jennifer L JL
Cadby Gemma G
den Heijer Martin M
Eklund Niina N
Fischer Krista K
Goel Anuj A
Hottenga Jouke-Jan JJ
Huffman Jennifer E JE
Jarick Ivonne I
Johansson Asa A
Johnson Toby T
Kanoni Stavroula S
Kleber Marcus E ME
König Inke R IR
Kristiansson Kati K
Kutalik Zoltán Z
Lamina Claudia C
Lecoeur Cecile C
Li Guo G
Mangino Massimo M
McArdle Wendy L WL
Medina-Gomez Carolina C
Müller-Nurasyid Martina M
Ngwa Julius S JS
Nolte Ilja M IM
Paternoster Lavinia L
Pechlivanis Sonali S
Perola Markus M
Peters Marjolein J MJ
Preuss Michael M
Rose Lynda M LM
Shi Jianxin J
Shungin Dmitry D
Smith Albert Vernon AV
Strawbridge Rona J RJ
Surakka Ida I
Teumer Alexander A
Trip Mieke D MD
Tyrer Jonathan J
Van Vliet- Ostaptchouk Jana V JV
Vandenput Liesbeth L
Waite Lindsay L LL
Zhao Jing Hua JH
Absher Devin D
Asselbergs Folkert W FW
Atalay Mustafa M
Attwood Antony P AP
Balmforth Anthony J AJ
Basart Hanneke H
Beilby John J
Bonnycastle Lori L LL
Brambilla Paolo P
Bruinenberg Marcel M
Campbell Harry H
Chasman Daniel I DI
Chines Peter S PS
Collins Francis S FS
Connell John M JM
Cookson William W
de Faire Ulf U
de Vegt Femmie F
Dei Mariano M
Dimitriou Maria M
Edkins Sarah S
Estrada Karol K
Evans David M DM
Farrall Martin M
Ferrario Marco M MM
Ferrières Jean J
Franke Lude L
Frau Francesca F
Gejman Pablo V PV
Grallert Harald H
Grönberg Henrik H
Gudnason Vilmundur V
Hall Alistair S AS
Hall Per P
Hartikainen Anna-Liisa AL
Hayward Caroline C
Heard-Costa Nancy L NL
Heath Andrew C AC
Hebebrand Johannes J
Homuth Georg G
Hu Frank B FB
Hunt Sarah E SE
Hyppönen Elina E
Iribarren Carlos C
Jacobs Kevin B KB
Jansson John-Olov JO
Jula Antti A
Kähönen Mika M
Kathiresan Sekar S
Kee Frank F
Khaw Kay-Tee KT
Kivimaki Mika M
Koenig Wolfgang W
Kraja Aldi T AT
Kumari Meena M
Kuulasmaa Kari K
Kuusisto Johanna J
Laitinen Jaana H JH
Lakka Timo A TA
Langenberg Claudia C
Launer Lenore J LJ
Lind Lars L
Lindström Jaana J
Liu Jianjun J
Liuzzi Antonio A
Lokki Marja-Liisa ML
Lorentzon Mattias M
Madden Pamela A PA
Magnusson Patrik K PK
Manunta Paolo P
Marek Diana D
März Winfried W
Mateo Leach Irene I
McKnight Barbara B
Medland Sarah E SE
Mihailov Evelin E
Milani Lili L
Montgomery Grant W GW
Mooser Vincent V
Mühleisen Thomas W TW
Munroe Patricia B PB
Musk Arthur W AW
Narisu Narisu N
Navis Gerjan G
Nicholson George G
Nohr Ellen A EA
Ong Ken K KK
Oostra Ben A BA
Palmer Colin N A CN
Palotie Aarno A
Peden John F JF
Pedersen Nancy N
Peters Annette A
Polasek Ozren O
Pouta Anneli A
Pramstaller Peter P PP
Prokopenko Inga I
Pütter Carolin C
Radhakrishnan Aparna A
Raitakari Olli O
Rendon Augusto A
Rivadeneira Fernando F
Rudan Igor I
Saaristo Timo E TE
Sambrook Jennifer G JG
Sanders Alan R AR
Sanna Serena S
Saramies Jouko J
Schipf Sabine S
Schreiber Stefan S
Schunkert Heribert H
Shin So-Youn SY
Signorini Stefano S
Sinisalo Juha J
Skrobek Boris B
Soranzo Nicole N
Stancakova Alena A
Stark Klaus K
Stephens Jonathan C JC
Stirrups Kathleen K
Stolk Ronald P RP
Stumvoll Michael M
Swift Amy J AJ
Theodoraki Eirini V EV
Thorand Barbara B
Tregouet David-Alexandre DA
Tremoli Elena E
Van der Klauw Melanie M MM
van Meurs Joyce B J JB
Vermeulen Sita H SH
Viikari Jorma J
Virtamo Jarmo J
Vitart Veronique V
Waeber Gérard G
Wang Zhaoming Z
Widen Elisabeth E
Wild Sarah H SH
Willemsen Gonneke G
Winkelmann Bernhard R BR
Witteman Jacqueline C M JC
Wolffenbuttel Bruce H R BH
Wong Andrew A
Wright Alan F AF
Zillikens M Carola M
Amouyel Philippe P
Boehm Bernhard O BO
Boerwinkle Eric E
Boomsma Dorret I DI
Caulfield Mark J MJ
Chanock Stephen J SJ
Cupples L Adrienne L
Cusi Daniele D
Dedoussis George V GV
Erdmann Jeanette J
Eriksson Johan G JG
Franks Paul W PW
Froguel Philippe P
Gieger Christian C
Gyllensten Ulf U
Hamsten Anders A
Harris Tamara B TB
Hengstenberg Christian C
Hicks Andrew A AA
Hingorani Aroon A
Hinney Anke A
Hofman Albert A
Hovingh Kees G KG
Hveem Kristian K
Illig Thomas T
Jarvelin Marjo-Riitta MR
Jöckel Karl-Heinz KH
Keinanen-Kiukaanniemi Sirkka M SM
Kiemeney Lambertus A LA
Kuh Diana D
Laakso Markku M
Lehtimäki Terho T
Levinson Douglas F DF
Martin Nicholas G NG
Metspalu Andres A
Morris Andrew D AD
Nieminen Markku S MS
Njølstad Inger I
Ohlsson Claes C
Oldehinkel Albertine J AJ
Ouwehand Willem H WH
Palmer Lyle J LJ
Penninx Brenda B
Power Chris C
Province Michael A MA
Psaty Bruce M BM
Qi Lu L
Rauramaa Rainer R
Ridker Paul M PM
Ripatti Samuli S
Salomaa Veikko V
Samani Nilesh J NJ
Snieder Harold H
Sørensen Thorkild I A TI
Spector Timothy D TD
Stefansson Kari K
Tönjes Anke A
Tuomilehto Jaakko J
Uitterlinden André G AG
Uusitupa Matti M
van der Harst Pim P
Vollenweider Peter P
Wallaschofski Henri H
Wareham Nicholas J NJ
Watkins Hugh H
Wichmann H -Erich H-
Wilson James F JF
Abecasis Goncalo R GR
Assimes Themistocles L TL
Barroso Ines I
Boehnke Michael M
Borecki Ingrid B IB
Deloukas Panos P
Fox Caroline S CS
Frayling Timothy T
Groop Leif C LC
Haritunian Talin T
Heid Iris M IM
Hunter David D
Kaplan Robert C RC
Karpe Fredrik F
Moffatt Miriam M
Mohlke Karen L KL
O'Connell Jeffrey R JR
Pawitan Yudi Y
Schadt Eric E EE
Schlessinger David D
Steinthorsdottir Valgerdur V
Strachan David P DP
Thorsteinsdottir Unnur U
van Duijn Cornelia M CM
Visscher Peter M PM
Di Blasio Anna Maria AM
Hirschhorn Joel N JN
Lindgren Cecilia M CM
Morris Andrew P AP
Meyre David D
Scherag André A
McCarthy Mark I MI
Speliotes Elizabeth K EK
North Kari E KE
Loos Ruth J F RJ
Ingelsson Erik E
JOURNAL
VOLUME: 10
ISSUE: 7
TITLE: PLoS genetics
ISOABBREVIATION: PLoS Genet.
YEAR: 2014
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1553-7404
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: PLoS Genet
COUNTRY: United States
ISSNLINKING: 1553-7390
NLMUNIQUEID: 101239074
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Hum Mol Genet. 2008 Oct 15;17(20):3154-65 18640990
Cites Arch Dis Child. 2007 Oct;92(10):876-80 17595200
Cites PLoS Genet. 2009 Feb;5(2):e1000365 19197348
Cites Genet Epidemiol. 2009 Jan;33(1):63-78 18636529
Cites Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17546-51 19805135
Cites Nature. 2009 Dec 17;462(7275):868-74 20016592
Cites BMC Genet. 2005;6 Suppl 1:S162 16451624
Cites Nat Genet. 2010 Nov;42(11):949-60 20935629
Cites Nat Genet. 2010 Nov;42(11):937-48 20935630
Cites J Pharmacol Exp Ther. 2007 Dec;323(3):924-34 17875609
Cites Hum Genet. 2008 Jan;122(6):625-34 17955261
Cites Genet Epidemiol. 2008 May;32(4):361-9 18271029
Cites Am J Hum Genet. 2008 Aug;83(2):193-9 18678320
Cites Eur J Hum Genet. 2008 Sep;16(9):1126-34 18398438
Cites Annu Rev Genomics Hum Genet. 2008;9:347-58 18544033
Cites Genet Epidemiol. 1999;17 Suppl 1:S289-94 10597451
Cites Hum Mol Genet. 2011 Feb 15;20(4):840-52 21131291
Cites Am J Epidemiol. 2011 Jul 15;174(2):226-33 21633117
Cites Diabetes. 2011 Aug;60(8):2197-201 21700879
Cites Genome Biol. 2011;12(3):R25 21418647
Cites Clin Genet. 2012 Mar;81(3):201-9 21933173
Cites PLoS Genet. 2012;8(8):e1002839 22876191
Cites Nature. 2012 Oct 11;490(7419):267-72 22982992
Cites J Clin Endocrinol Metab. 2012 Nov;97(11):E2160-7 22893713
Cites Pediatr Obes. 2013 Jun;8(3):159-69 23042783
Cites Nat Rev Genet. 2013 Sep;14(9):609-17 23917626
Cites Ann Nutr Metab. 2013;63(1-2):32-41 23887153
Cites Am J Hum Genet. 2013 Aug 8;93(2):390-7 23910463
Cites Genet Epidemiol. 1999;17 Suppl 1:S409-13 10597471
Cites Diabetes. 2001 Dec;50(12):2850-7 11723070
Cites Am J Hum Genet. 2005 Mar;76(3):427-37 15647995
Cites Genomics. 2006 Apr;87(4):543-51 16413163
Cites J Clin Endocrinol Metab. 2006 Oct;91(10):4001-5 16835282
Cites Am J Hum Genet. 2007 Apr;80(4):605-15 17357068
Cites Curr Diabetes Rev. 2008 Nov;4(4):329-39 18991601
GRANTS
GRANTID AGENCY COUNTRY
084723/Z/08/Z Wellcome Trust United Kingdom
0927310 Medical Research Council United Kingdom
0927310 Wellcome Trust United Kingdom
097117 Wellcome Trust United Kingdom
1RL1MH083268-01 NIMH NIH HHS United States
5R01HL087679-02 NHLBI NIH HHS United States
5R01MH63706:02 NIMH NIH HHS United States
AA014041 NIAAA NIH HHS United States
AA07535 NIAAA NIH HHS United States
AA10248 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA13326 NIAAA NIH HHS United States
BB/F019394/1 Biotechnology and Biological Sciences Research Council United Kingdom
CZD/16/6/4 Chief Scientist Office United Kingdom
DA12854 NIDA NIH HHS United States
G0100266 Medical Research Council United Kingdom
G0500539 Medical Research Council United Kingdom
G0600705 Medical Research Council United Kingdom
G0601966 Medical Research Council United Kingdom
G0700931 Medical Research Council United Kingdom
G0701863 Medical Research Council United Kingdom
G1002319 Medical Research Council United Kingdom
G9815508 Medical Research Council United Kingdom
HHSN268200625226C PHS HHS United States
HHSN268201100005C PHS HHS United States
HHSN268201100006C PHS HHS United States
HHSN268201100007C PHS HHS United States
HHSN268201100008C PHS HHS United States
HHSN268201100009C PHS HHS United States
HHSN268201100010C PHS HHS United States
HHSN268201100011C PHS HHS United States
HHSN268201100012C PHS HHS United States
MC_PC_15018 Medical Research Council United Kingdom
MC_PC_U127561128 Medical Research Council United Kingdom
MC_U106179471 Medical Research Council United Kingdom
MC_UP_0801/1 Medical Research Council United Kingdom
MC_UU_12013/1 Medical Research Council United Kingdom
MC_UU_12015/1 Medical Research Council United Kingdom
MR/K013351/1 Medical Research Council United Kingdom
MR/K026992/1 Medical Research Council United Kingdom
P30 DK079637 NIDDK NIH HHS United States
R01DK8925601 NIDDK NIH HHS United States
R01HL086694 NHLBI NIH HHS United States
R01HL087641 NHLBI NIH HHS United States
R01HL59367 NHLBI NIH HHS United States
T32 HL007055 NHLBI NIH HHS United States
T32 HL091823 NHLBI NIH HHS United States
U01HG004402 NHGRI NIH HHS United States
UL1RR025005 NCRR NIH HHS United States
WT083431MA Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Body Mass Index
European Continental Ancestry Group genetics
Female genetics
Gene Expression Regulation genetics
Genetic Predisposition to Disease genetics
Genome-Wide Association Study genetics
Genomic Imprinting genetics
Genotype genetics
Glucose Transport Proteins, Facilitative genetics
Humans genetics
Male genetics
Obesity pathology
Polymorphism, Single Nucleotide genetics
Potassium Channels, Tandem Pore Domain genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Glucose Transport Proteins, Facilitative
0 KCNK9 protein, human
0 Potassium Channels, Tandem Pore Domain
0 SLC2A10 protein, human
OTHER ID's
OTHERID SOURCE
PMC4117451 NLM