Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24973604
TITLE
Investigating brain connectivity heritability in a twin study using diffusion imaging data.
ABSTRACT
Heritability of brain anatomical connectivity has been studied with diffusion-weighted imaging (DWI) mainly by modeling each voxel's diffusion pattern as a tensor (e.g., to compute fractional anisotropy), but this method cannot accurately represent the many crossing connections present in the brain. We hypothesized that different brain networks (i.e., their component fibers) might have different heritability and we investigated brain connectivity using High Angular Resolution Diffusion Imaging (HARDI) in a cohort of twins comprising 328 subjects that included 70 pairs of monozygotic and 91 pairs of dizygotic twins. Water diffusion was modeled in each voxel with a Fiber Orientation Distribution (FOD) function to study heritability for multiple fiber orientations in each voxel. Precision was estimated in a test-retest experiment on a sub-cohort of 39 subjects. This was taken into account when computing heritability of FOD peaks using an ACE model on the monozygotic and dizygotic twins. Our results confirmed the overall heritability of the major white matter tracts but also identified differences in heritability between connectivity networks. Inter-hemispheric connections tended to be more heritable than intra-hemispheric and cortico-spinal connections. The highly heritable tracts were found to connect particular cortical regions, such as medial frontal cortices, postcentral, paracentral gyri, and the right hippocampus.
Crown Copyright 2014. Published by Elsevier Inc. All rights reserved.
DATE PUBLISHED
2014 Oct 15
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/02/12
revised 2014/06/04
accepted 2014/06/18
aheadofprint 2014/06/26
entrez 2014/06/29 06:00
pubmed 2014/06/29 06:00
medline 2015/05/13 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Shen KK Shen Kai-Kai KK CSIRO Computational Informatics, Herston, QLD 4029, Australia.
Rose S Rose Stephen S CSIRO Computational Informatics, Herston, QLD 4029, Australia.
Fripp J Fripp Jurgen J CSIRO Computational Informatics, Herston, QLD 4029, Australia.
McMahon KL McMahon Katie L KL Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.
de Zubicaray GI de Zubicaray Greig I GI School of Psychology, University of Queensland, Brisbane, Australia.
Martin NG Martin Nicholas G NG Queensland Institute of Medical Research, Brisbane, Australia.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of South California, Marina del Rey, CA, USA.
Wright MJ Wright Margaret J MJ Queensland Institute of Medical Research, Brisbane, Australia.
Salvado O Salvado Olivier O CSIRO Computational Informatics, Herston, QLD 4029, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 100
ISSUE:
TITLE: NeuroImage
ISOABBREVIATION: Neuroimage
YEAR: 2014
MONTH: Oct
DAY: 15
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1095-9572
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neuroimage
COUNTRY: United States
ISSNLINKING: 1053-8119
NLMUNIQUEID: 9215515
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
P41 EB015922 NIBIB NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
U54 EB020403 NIBIB NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Cerebral Cortex physiology
Diffusion Magnetic Resonance Imaging methods
Diffusion Tensor Imaging methods
Female methods
Humans methods
Male methods
Nerve Fibers, Myelinated physiology
Nerve Net physiology
Neural Pathways physiology
Twins genetics
White Matter physiology
Young Adult physiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS648523 NLM
PMC4291188 NLM