Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24957864
TITLE
Genetic predisposition to schizophrenia associated with increased use of cannabis.
ABSTRACT
Cannabis is the most commonly used illicit drug worldwide. With debate surrounding the legalization and control of use, investigating its health risks has become a pressing area of research. One established association is that between cannabis use and schizophrenia, a debilitating psychiatric disorder affecting ~1% of the population over their lifetime. Although considerable evidence implicates cannabis use as a component cause of schizophrenia, it remains unclear whether this is entirely due to cannabis directly raising risk of psychosis, or whether the same genes that increases psychosis risk may also increase risk of cannabis use. In a sample of 2082 healthy individuals, we show an association between an individual's burden of schizophrenia risk alleles and use of cannabis. This was significant both for comparing those who have ever versus never used cannabis (P=2.6 ? 10(-4)), and for quantity of use within users (P=3.0 ? 10(-3)). Although directly predicting only a small amount of the variance in cannabis use, these findings suggest that part of the association between schizophrenia and cannabis is due to a shared genetic aetiology. This form of gene-environment correlation is an important consideration when calculating the impact of environmental risk factors, including cannabis use.
DATE PUBLISHED
2014 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/01/22
revised 2014/03/18
accepted 2014/04/22
aheadofprint 2014/06/24
entrez 2014/06/25 06:00
pubmed 2014/06/25 06:00
medline 2014/06/25 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Power RA Power R A RA 1] MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK [2] Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia.
Verweij KJ Verweij K J H KJ Department of Developmental Psychology and EMGO Institute for Health and Care Research, VU University, Amsterdam, The Netherlands.
Zuhair M Zuhair M M MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
Montgomery GW Montgomery G W GW QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Henders AK Henders A K AK QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Heath AC Heath A C AC Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Madden PA Madden P A F PA Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Medland SE Medland S E SE QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Wray NR Wray N R NR Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia.
Martin NG Martin N G NG QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 19
ISSUE: 11
TITLE: Molecular psychiatry
ISOABBREVIATION: Mol. Psychiatry
YEAR: 2014
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5578
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Mol Psychiatry
COUNTRY: England
ISSNLINKING: 1359-4184
NLMUNIQUEID: 9607835
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA07580 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA14041 NIAAA NIH HHS United States
AA17688 NIAAA NIH HHS United States
DA012854 NIDA NIH HHS United States
DA018267 NIDA NIH HHS United States
DA018660 NIDA NIH HHS United States
DA019951 NIDA NIH HHS United States
DA23668 NIDA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
K08 DA019951 NIDA NIH HHS United States
R01 AA007535 NIAAA NIH HHS United States
R01 AA010249 NIAAA NIH HHS United States
R01 AA013320 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 DA023668 NIDA NIH HHS United States
R37 AA007728 NIAAA NIH HHS United States
T32 AA007580 NIAAA NIH HHS United States
Department of Health United Kingdom
Medical Research Council United Kingdom
GENERAL NOTE
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