Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24950379
TITLE
Variants close to NTRK2 gene are associated with birth weight in female twins.
ABSTRACT
Low weight at birth has previously been shown to be associated with a number of adult diseases such as type 2 diabetes, cardiovascular disease, high blood pressure, and obesity later in life. Genome-wide association studies (GWAS) have been published for singleton-born individuals, but the role of genetic variation in birth weight (BW) in twins has not yet been fully investigated. A GWAS was performed in 4,593 female study participants with BW data available from the TwinsUK cohort. A genome-wide significant signal was found in chromosome 9, close to the NTRK2 gene (OMIM: 600456). QIMR, an Australian twin cohort (n = 3,003), and UK-based singleton-birth individuals from the Hertfordshire cohort (n = 2,997) were used as replication for the top two single nucleotide polymorphism (SNPs) underpinning this signal, rs12340987 and rs7849941. The top SNP, rs12340987, was found to be in the same direction in the Australian twins and in the singleton-born females (fixed effects meta-analysis beta = -0.13, SE = 0.02, and p = 1.48 ? 10-8) but not in the singleton-born males tested. These findings provide an important insight into the genetic component of BW in twins who are normally excluded due to their lower BW when compared with singleton births, as well as the difference in BW between twins. The NTRK2 gene identified in this study has previously been associated with obesity.
DATE PUBLISHED
2014 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2014/06/20
entrez 2014/06/21 06:00
pubmed 2014/06/21 06:00
medline 2014/06/21 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Metrustry SJ Metrustry Sarah J SJ Department of Twin Research and Genetic Epidemiology,King's College London,St Thomas' Hospital,London,UK.
Edwards MH Edwards Mark H MH MRC Lifecourse Epidemiology Unit,University of Southampton,Southampton General Hospital,Southampton,UK.
Medland SE Medland Sarah E SE Department of Quantitative Genetics,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Holloway JW Holloway John W JW Department of Human Development and Health,Faculty of Medicine,University of Southampton,Southampton,UK.
Montgomery GW Montgomery Grant W GW Department of Molecular Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Martin NG Martin Nicholas G NG Department of Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Spector TD Spector Tim D TD Department of Twin Research and Genetic Epidemiology,King's College London,St Thomas' Hospital,London,UK.
Cooper C Cooper Cyrus C MRC Lifecourse Epidemiology Unit,University of Southampton,Southampton General Hospital,Southampton,UK.
Valdes AM Valdes Ana M AM Department of Twin Research and Genetic Epidemiology,King's College London,St Thomas' Hospital,London,UK.
INVESTIGATORS
JOURNAL
VOLUME: 17
ISSUE: 4
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2014
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA10248 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA13326 NIAAA NIH HHS United States
AA14041 NIAAA NIH HHS United States
MC_UP_A620_1014 Medical Research Council United Kingdom
MC_UU_12011/1 Medical Research Council United Kingdom
MH66206 NIMH NIH HHS United States
U1475000001 Medical Research Council United Kingdom
Arthritis Research UK United Kingdom
Wellcome Trust United Kingdom
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