Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
24828478
TITLE
Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory.
ABSTRACT
Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49 %, respectively, based on a meta-analysis of six twin cohorts, total N = 29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized.
DATE PUBLISHED
2014 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2013/10/21
accepted 2014/03/20
aheadofprint 2014/05/15
entrez 2014/05/16 06:00
pubmed 2014/05/16 06:00
medline 2015/04/07 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
van den Berg SM van den Berg Stéphanie M SM Department of Research Methodology, Measurement and Data-Analysis, University of Twente, Enschede, The Netherlands, stephanie.vandenberg@utwente.nl.
de Moor MH de Moor Marleen H M MH
McGue M McGue Matt M
Pettersson E Pettersson Erik E
Terracciano A Terracciano Antonio A
Verweij KJ Verweij Karin J H KJ
Amin N Amin Najaf N
Derringer J Derringer Jaime J
Esko T Esko Tõnu T
van Grootheest G van Grootheest Gerard G
Hansell NK Hansell Narelle K NK
Huffman J Huffman Jennifer J
Konte B Konte Bettina B
Lahti J Lahti Jari J
Luciano M Luciano Michelle M
Matteson LK Matteson Lindsay K LK
Viktorin A Viktorin Alexander A
Wouda J Wouda Jasper J
Agrawal A Agrawal Arpana A
Allik J Allik Jüri J
Bierut L Bierut Laura L
Broms U Broms Ulla U
Campbell H Campbell Harry H
Smith GD Smith George Davey GD
Eriksson JG Eriksson Johan G JG
Ferrucci L Ferrucci Luigi L
Franke B Franke Barbera B
Fox JP Fox Jean-Paul JP
de Geus EJ de Geus Eco J C EJ
Giegling I Giegling Ina I
Gow AJ Gow Alan J AJ
Grucza R Grucza Richard R
Hartmann AM Hartmann Annette M AM
Heath AC Heath Andrew C AC
Heikkilä K Heikkilä Kauko K
Iacono WG Iacono William G WG
Janzing J Janzing Joost J
Jokela M Jokela Markus M
Kiemeney L Kiemeney Lambertus L
Lehtimäki T Lehtimäki Terho T
Madden PA Madden Pamela A F PA
Magnusson PK Magnusson Patrik K E PK
Northstone K Northstone Kate K
Nutile T Nutile Teresa T
Ouwens KG Ouwens Klaasjan G KG
Palotie A Palotie Aarno A
Pattie A Pattie Alison A
Pesonen AK Pesonen Anu-Katriina AK
Polasek O Polasek Ozren O
Pulkkinen L Pulkkinen Lea L
Pulkki-Råback L Pulkki-Råback Laura L
Raitakari OT Raitakari Olli T OT
Realo A Realo Anu A
Rose RJ Rose Richard J RJ
Ruggiero D Ruggiero Daniela D
Seppälä I Seppälä Ilkka I
Slutske WS Slutske Wendy S WS
Smyth DC Smyth David C DC
Sorice R Sorice Rossella R
Starr JM Starr John M JM
Sutin AR Sutin Angelina R AR
Tanaka T Tanaka Toshiko T
Verhagen J Verhagen Josine J
Vermeulen S Vermeulen Sita S
Vuoksimaa E Vuoksimaa Eero E
Widen E Widen Elisabeth E
Willemsen G Willemsen Gonneke G
Wright MJ Wright Margaret J MJ
Zgaga L Zgaga Lina L
Rujescu D Rujescu Dan D
Metspalu A Metspalu Andres A
Wilson JF Wilson James F JF
Ciullo M Ciullo Marina M
Hayward C Hayward Caroline C
Rudan I Rudan Igor I
Deary IJ Deary Ian J IJ
Räikkönen K Räikkönen Katri K
Arias Vasquez A Arias Vasquez Alejandro A
Costa PT Costa Paul T PT
Keltikangas-Järvinen L Keltikangas-Järvinen Liisa L
van Duijn CM van Duijn Cornelia M CM
Penninx BW Penninx Brenda W J H BW
Krueger RF Krueger Robert F RF
Evans DM Evans David M DM
Kaprio J Kaprio Jaakko J
Pedersen NL Pedersen Nancy L NL
Martin NG Martin Nicholas G NG
Boomsma DI Boomsma Dorret I DI
INVESTIGATORS
JOURNAL
VOLUME: 44
ISSUE: 4
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2014
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1573-3297
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Stat Med. 2013 Jul 30;32(17):2988-3005 23212734
Cites Nat Genet. 2013 Sep;45(9):984-94 23933821
Cites Nat Genet. 2013 Oct;45(10):1150-9 23974872
Cites Br J Math Stat Psychol. 2013 Nov;66(3):383-401 23039871
Cites Alcohol Clin Exp Res. 2013 Dec;37(12):2108-17 23841856
Cites Genet Epidemiol. 2012 Dec;36(8):882-9 22965845
Cites Behav Genet. 2000 Mar;30(2):147-58 10979605
Cites J Pers Soc Psychol. 1994 Apr;66(4):762-75 8189351
Cites J Pers Soc Psychol. 2005 Jan;88(1):139-57 15631580
Cites Behav Genet. 2005 Nov;35(6):707-21 16273321
Cites Mol Psychiatry. 2012 Mar;17(3):337-49 21173776
Cites Nat Rev Genet. 2012 Aug;13(8):537-51 22777127
Cites Transl Psychiatry. 2012;2:e116 22832960
Cites Psychiatry Res. 2013 Mar 30;206(1):75-80 23021911
Cites Nat Genet. 2013 May;45(5):501-12 23563607
Cites Behav Genet. 2007 Jul;37(4):604-16 17534709
Cites Mol Psychiatry. 2008 Mar;13(3):302-12 17667963
Cites Mol Psychiatry. 2008 Jul;13(7):649-53 18504426
Cites Arch Gen Psychiatry. 2008 Sep;65(9):1062-71 18762592
Cites Clin Psychol Rev. 2008 Dec;28(8):1326-42 18708274
Cites Biol Psychiatry. 2009 Dec 15;66(12):1131-8 19748081
Cites J Clin Epidemiol. 2010 May;63(5):543-9 19880281
Cites Psychol Med. 2010 May;40(5):801-6 19732485
Cites Mol Psychiatry. 2010 Jun;15(6):647-56 18957941
Cites Nature. 2010 Oct 14;467(7317):832-8 20881960
Cites Nat Genet. 2010 Nov;42(11):937-48 20935630
Cites Annu Rev Clin Psychol. 2011;7:269-95 21166535
Cites Mol Psychiatry. 2012 Jan;17(1):36-48 21042317
GRANTS
GRANTID AGENCY COUNTRY
092731 Wellcome Trust United Kingdom
15/SAG09977 Biotechnology and Biological Sciences Research Council United Kingdom
AA-00145 NIAAA NIH HHS United States
AA-09203 NIAAA NIH HHS United States
AA-12502 NIAAA NIH HHS United States
AA014041 NIAAA NIH HHS United States
AA06781 NIAAA NIH HHS United States
AA07535 NIAAA NIH HHS United States
AA07580 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA10248 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA13326 NIAAA NIH HHS United States
AA15416 NIAAA NIH HHS United States
AGO4954 PHS HHS United States
BB/F019394/1 Biotechnology and Biological Sciences Research Council United Kingdom
CZB/4/505 Chief Scientist Office United Kingdom
CZB/4/710 Chief Scientist Office United Kingdom
CZG/3/2/79 Chief Scientist Office United Kingdom
DA019951 NIDA NIH HHS United States
DA12854 NIDA NIH HHS United States
DK U01-066134 NIDDK NIH HHS United States
ETM/55 Chief Scientist Office United Kingdom
G0700704 Medical Research Council United Kingdom
G9815508 Medical Research Council United Kingdom
GM30250 NIGMS NIH HHS United States
HHSN271200477451C PHS HHS United States
K05 AA017688 NIAAA NIH HHS United States
MC_PC_15018 Medical Research Council United Kingdom
MH40828 NIMH NIH HHS United States
MH66206 NIMH NIH HHS United States
MR/K026992/1 Medical Research Council United Kingdom
P01 CA089392 NCI NIH HHS United States
R01 AA009367 NIAAA NIH HHS United States
R01 AA011886 NIAAA NIH HHS United States
R01 AA012502 NIAAA NIH HHS United States
R01 DA013240 NIDA NIH HHS United States
R01 MH066140 NIMH NIH HHS United States
R01AA009367 NIAAA NIH HHS United States
R01AA011886 NIAAA NIH HHS United States
R01DA013240 NIDA NIH HHS United States
R01MH066140 NIMH NIH HHS United States
R37 DA005147 NIDA NIH HHS United States
R37DA005147 NIDA NIH HHS United States
U01 HG004422 NHGRI NIH HHS United States
U01 HG004446 NHGRI NIH HHS United States
U10 AA008401 NIAAA NIH HHS United States
U10AA008401 NIAAA NIH HHS United States
Intramural NIH HHS United States
Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Anxiety Disorders genetics
Extraversion (Psychology) genetics
Genome-Wide Association Study genetics
Humans genetics
Models, Statistical genetics
Personality genetics
Personality Assessment genetics
Phenotype genetics
SUPPLEMENTARY MESH
SUPPLMESHNAME SUPPLMESHTYPE
Neuroticism Disease
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC4057636 NLM