Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24760386
TITLE
Overlapping genetic and environmental influences on nonsuicidal self-injury and suicidal ideation: different outcomes, same etiology?
ABSTRACT
IMPORTANCE NlmCategory: OBJECTIVE
Nonsuicidal self-injury (NSSI) and suicidal self-injury are very harmful behaviors and are associated with several psychiatric disorders. In the recently developed fifth edition of the DSM, NSSI and suicidal behavior disorder are for the first time introduced as conditions in their own right instead of symptoms of other psychiatric disorders. It is unclear to what extent NSSI and suicidal self-injury share the same underlying biological mechanisms and are influenced by the same environmental factors.
OBJECTIVE NlmCategory: OBJECTIVE
To determine the relative importance of genetic and environmental influences on the variation in NSSI and suicidal ideation and their covariation.
DESIGN, SETTING, AND PARTICIPANTS NlmCategory: METHODS
Classical twin design using a sample of 10,678 male and female adult twins (mean [SD] age, 32.76 [6.99] years) from the Australian Twin Registry, a population-based twin registry. Between 1996 and 2009, the twins participated in semistructured telephone interviews that primarily focused on psychiatric disorders.
MAIN OUTCOMES AND MEASURES NlmCategory: METHODS
Lifetime presence of self-reported NSSI and suicidal ideation. RESULTS The prevalences of NSSI and suicidal ideation were 4.7% and 26.5%, respectively, and individuals who engaged in self-harm were much more likely to report suicidal ideation (odds ratio = 8.39; 95% CI, 6.84-10.29). Results from a bivariate genetic model indicated that genetic factors explain a substantial part of the variance in both NSSI (37% for men and 59% for women) and suicidal ideation (41% for men and 55% for women), while residual influences (including nonshared environmental influences and measurement error) explain the remainder of the variance. Shared (family) environment did not seem to play a role. Moreover, both behaviors were strongly correlated (r = 0.49 for men and 0.61 for women), and this correlation was largely explained by overlapping genetic influences (76% for men and 62% for women), whereas residual influences accounted for the remainder of the phenotypic correlation.
CONCLUSIONS AND RELEVANCE NlmCategory: CONCLUSIONS
Results indicated that the substantial correlation between NSSI and suicidal ideation is largely driven by overlapping genetic factors, suggesting that the 2 behaviors share similar biological underpinnings. Overlapping residual influences also explain part of the covariance between the 2 traits. Future research should further investigate which genetic and environmental influences underlie the vulnerability to NSSI and suicidal ideation.
DATE PUBLISHED
2014 Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2014/04/25 06:00
pubmed 2014/04/25 06:00
medline 2014/08/13 06:00
pmc-release 2015/06/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Maciejewski DF Maciejewski Dominique F DF Department of Developmental Psychology and EMGO Institute for Health and Care Research, VU University, Amsterdam, the Netherlands.
Creemers HE Creemers Hanneke E HE Department of Developmental Psychology and EMGO Institute for Health and Care Research, VU University, Amsterdam, the Netherlands.
Lynskey MT Lynskey Michael T MT Addictions Department, Institute of Psychiatry, King's College London, London, England.
Madden PA Madden Pamela A F PA Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri.
Heath AC Heath Andrew C AC Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri.
Statham DJ Statham Dixie J DJ Faculty of Arts and Social Sciences, University of the Sunshine Coast, Sippy Downs, Australia.
Martin NG Martin Nicholas G NG Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Verweij KJ Verweij Karin J H KJ Department of Developmental Psychology and EMGO Institute for Health and Care Research, VU University, Amsterdam, the Netherlands.
INVESTIGATORS
JOURNAL
VOLUME: 71
ISSUE: 6
TITLE: JAMA psychiatry
ISOABBREVIATION: JAMA Psychiatry
YEAR: 2014
MONTH: Jun
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2168-6238
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: JAMA Psychiatry
COUNTRY: United States
ISSNLINKING: 2168-622X
NLMUNIQUEID: 101589550
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA0758O NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA14041 NIAAA NIH HHS United States
AA17688 NIAAA NIH HHS United States
DA012854 NIDA NIH HHS United States
DA018267 NIDA NIH HHS United States
DA018660 NIDA NIH HHS United States
DA019951 NIDA NIH HHS United States
DA23668 NIDA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
K08 DA019951 NIDA NIH HHS United States
P50 AA011998 NIAAA NIH HHS United States
P60 AA011998 NIAAA NIH HHS United States
R01 AA007535 NIAAA NIH HHS United States
R01 AA007728 NIAAA NIH HHS United States
R01 AA010249 NIAAA NIH HHS United States
R01 AA013320 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 AA014041 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 DA018267 NIDA NIH HHS United States
R01 DA018660 NIDA NIH HHS United States
R01 DA023668 NIDA NIH HHS United States
R56 DA012854 NIDA NIH HHS United States
T32 AA007580 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Australia
Environment
Female
Humans
Male
Middle Aged
Models, Genetic
Registries
Self Report
Self-Injurious Behavior psychology
Sex Factors psychology
Suicidal Ideation psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS642262 [Available on 06/01/15] NLM
PMC4241464 [Available on 06/01/15] NLM